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• W2052043908 abstract "Abstract Mechanical allodynia, such as static and dynamic allodynia, is a prominent feature of neuropathic pain syndromes. The aim of this study is to characterize primary sensory neurons mediating the mechanical allodynia in a rat chronic constriction injury (CCI) model with a combination of pharmacological and histological investigations. N-(4-Tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a selective and competitive antagonist of the vanilloid receptor 1 (TRPV1), and resiniferatoxin, which causes desensitization of TRPV1-expressing fibres, suppressed static allodynia but not dynamic allodynia in CCI rats. Immunohistochemical studies of TRPV1 and NF200, an A-fibre marker 200 kDa neurofilament, in dorsal root ganglion neurons demonstrated that each 48% of the positive-stained neurons were immunoreactive only for TRPV1 or NF200. The other 4% of stained neurons were double-positive for TRPV1 and NF200. Of the TRPV1-positive neurons, more than 99% were small- (diameter &lt;25 μm) and medium- (25–45 μm) sized. In contrast, 97% of NF200 single-labelled neurons were medium- and large- (&gt;45 μm) sized. These findings suggest that two types of mechanical allodynia are transmitted by different primary sensory neurons: static allodynia is mediated by TRPV1 positive small- and medium-sized neurons and dynamic allodynia might be signalled by TRPV1-negative medium- and large-sized neurons." @default.
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• W2052043908 date "2008-06-01" @default.
• W2052043908 modified "2023-10-03" @default.
• W2052043908 title "Characterization of primary sensory neurons mediating static and dynamic allodynia in rat chronic constriction injury model" @default.
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• W2052043908 doi "https://doi.org/10.1211/jpp.60.6.0006" @default.
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