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- W2052044181 abstract "Abstract Human cells (WI-38, passage 22 and leukocyte cultures) were treated in vitro with ethylenimine solution of various concentrations for various lengths of time before fixation. The findings are as follows: 1. (1) Ethylenimine was cytotoxic to the cells at the concentration of IO −2M or higher. 2. (2) Only chromatid gaps, breaks, and exchanges were recovered. 3. (3) Cells treated for 3.5 h before fixation with ethylenimine showed little damage; only 7% of the cells showed aberrations. This is not significantly higher than the control value of 4%. On the other hand, 29% of the cells had aberrations when treated similarly for 8 h. This suggests that aberrations are induced primarily in the S-period. 4. (4) This was confirmed by autoradiography by treating leukocyte cultures for 8 h with ethylenimine and [3H]thymidine. 56 cells out of 100 had aberrations. Of these 56 cells all but 4 were labeled. 5. (5) A significantly high number of aberrations were still found 7 days after the treatment. This might be similar to the delayed action found in Drosophila, although one cannot rule out the possibility that the chemical or its active product persisted in the cytoplasm after the actual treatment. The question of the sensitivity of G1 cells to ethylenimine remains unresolved." @default.
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- W2052044181 date "1967-02-01" @default.
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- W2052044181 title "Induction of chromosome aberrations in cultured human cells by ethylenimine and its relation to cell cycle" @default.
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- W2052044181 doi "https://doi.org/10.1016/0027-5107(67)90112-1" @default.
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