FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052050650> ?p ?o ?g. }

• W2052050650 endingPage "189" @default.
• W2052050650 startingPage "183" @default.
• W2052050650 abstract "Inbred albino Louvain (LOU) rats are considered a model of healthy aging due to their increased longevity in the absence of obesity and with a low incidence of common age-related diseases. In this study, we characterized the bone phenotype of male and female LOU rats at 4, 20 and 27 months of age using quantitative micro computed tomographic (mCT) imaging, histology and biochemical analysis of circulating bone biomarkers. Bone quality and morphometry of the distal femora, assessed by mCT, was similar in male and female rats at 4 months of age and deteriorated over time. Histochemical staining of undecalcified bone showed a significant reduction in cortical and trabecular bone by 20 months of age. The reduction in mineralized tissue was accompanied by reduced numbers of osteoblasts and osteoclasts and a significant increase in marrow adiposity. Biochemical markers of bone turnover, C-telopeptide and osteocalcin, correlated with the age-related bone loss whereas the calciotropic hormones PTH and vitamin D remained unchanged over time. In summary, aged LOU rats exhibit low-turnover bone loss and marrow fat infiltration, which are the hallmarks of senile osteoporosis, and thus represent a novel model in which to study the molecular mechanisms leading to this disorder." @default.
• W2052050650 created "2016-06-24" @default.
• W2052050650 creator A5000432967 @default.
• W2052050650 creator A5017480530 @default.
• W2052050650 creator A5039407682 @default.
• W2052050650 creator A5047944812 @default.
• W2052050650 creator A5059544360 @default.
• W2052050650 creator A5080113423 @default.
• W2052050650 creator A5083330410 @default.
• W2052050650 date "2009-03-01" @default.
• W2052050650 modified "2023-10-11" @default.
• W2052050650 title "Age-related bone loss in the LOU/c rat model of healthy ageing" @default.
• W2052050650 cites W1536179852 @default.
• W2052050650 cites W1565369626 @default.
• W2052050650 cites W1965523106 @default.
• W2052050650 cites W1999453868 @default.
• W2052050650 cites W2008162890 @default.
• W2052050650 cites W2010348816 @default.
• W2052050650 cites W2010417274 @default.
• W2052050650 cites W2012579495 @default.
• W2052050650 cites W2013891487 @default.
• W2052050650 cites W2040542461 @default.
• W2052050650 cites W2046002024 @default.
• W2052050650 cites W2056810908 @default.
• W2052050650 cites W2057737927 @default.
• W2052050650 cites W2061443387 @default.
• W2052050650 cites W2069811152 @default.
• W2052050650 cites W2077625765 @default.
• W2052050650 cites W2078156116 @default.
• W2052050650 cites W2080756176 @default.
• W2052050650 cites W2081195720 @default.
• W2052050650 cites W2084388382 @default.
• W2052050650 cites W2087378917 @default.
• W2052050650 cites W2089602036 @default.
• W2052050650 cites W2093990675 @default.
• W2052050650 cites W2117179448 @default.
• W2052050650 cites W2138582366 @default.
• W2052050650 cites W2147701985 @default.
• W2052050650 cites W2153217134 @default.
• W2052050650 doi "https://doi.org/10.1016/j.exger.2008.10.004" @default.
• W2052050650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18992316" @default.
• W2052050650 hasPublicationYear "2009" @default.
• W2052050650 type Work @default.
• W2052050650 sameAs 2052050650 @default.
• W2052050650 citedByCount "46" @default.
• W2052050650 countsByYear W20520506502012 @default.
• W2052050650 countsByYear W20520506502013 @default.
• W2052050650 countsByYear W20520506502014 @default.
• W2052050650 countsByYear W20520506502015 @default.
• W2052050650 countsByYear W20520506502016 @default.
• W2052050650 countsByYear W20520506502017 @default.
• W2052050650 countsByYear W20520506502018 @default.
• W2052050650 countsByYear W20520506502019 @default.
• W2052050650 countsByYear W20520506502020 @default.
• W2052050650 countsByYear W20520506502021 @default.
• W2052050650 countsByYear W20520506502022 @default.
• W2052050650 countsByYear W20520506502023 @default.
• W2052050650 crossrefType "journal-article" @default.
• W2052050650 hasAuthorship W2052050650A5000432967 @default.
• W2052050650 hasAuthorship W2052050650A5017480530 @default.
• W2052050650 hasAuthorship W2052050650A5039407682 @default.
• W2052050650 hasAuthorship W2052050650A5047944812 @default.
• W2052050650 hasAuthorship W2052050650A5059544360 @default.
• W2052050650 hasAuthorship W2052050650A5080113423 @default.
• W2052050650 hasAuthorship W2052050650A5083330410 @default.
• W2052050650 hasConcept C126322002 @default.
• W2052050650 hasConcept C131075544 @default.
• W2052050650 hasConcept C134018914 @default.
• W2052050650 hasConcept C160160445 @default.
• W2052050650 hasConcept C170033053 @default.
• W2052050650 hasConcept C170493617 @default.
• W2052050650 hasConcept C181199279 @default.
• W2052050650 hasConcept C2775843772 @default.
• W2052050650 hasConcept C2776033226 @default.
• W2052050650 hasConcept C2776541429 @default.
• W2052050650 hasConcept C2780007613 @default.
• W2052050650 hasConcept C500499127 @default.
• W2052050650 hasConcept C55493867 @default.
• W2052050650 hasConcept C71924100 @default.
• W2052050650 hasConcept C86803240 @default.
• W2052050650 hasConceptScore W2052050650C126322002 @default.
• W2052050650 hasConceptScore W2052050650C131075544 @default.
• W2052050650 hasConceptScore W2052050650C134018914 @default.
• W2052050650 hasConceptScore W2052050650C160160445 @default.
• W2052050650 hasConceptScore W2052050650C170033053 @default.
• W2052050650 hasConceptScore W2052050650C170493617 @default.
• W2052050650 hasConceptScore W2052050650C181199279 @default.
• W2052050650 hasConceptScore W2052050650C2775843772 @default.
• W2052050650 hasConceptScore W2052050650C2776033226 @default.
• W2052050650 hasConceptScore W2052050650C2776541429 @default.
• W2052050650 hasConceptScore W2052050650C2780007613 @default.
• W2052050650 hasConceptScore W2052050650C500499127 @default.
• W2052050650 hasConceptScore W2052050650C55493867 @default.
• W2052050650 hasConceptScore W2052050650C71924100 @default.
• W2052050650 hasConceptScore W2052050650C86803240 @default.
• W2052050650 hasIssue "3" @default.
• W2052050650 hasLocation W20520506501 @default.
• W2052050650 hasLocation W20520506502 @default.

• next