Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052051246> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2052051246 endingPage "102" @default.
- W2052051246 startingPage "97" @default.
- W2052051246 abstract "The capacity for the neurotrophic factor PACAP38 to regulate expression of nerve growth factor (NGF)-trkA receptors in PC12 cells has been examined. Treatment of PC12 cells with 5 nM PACAP38 for 48 h elicited a 2.5-fold increase in 125I-NGF binding sites. FACS and Western analysis of trkA receptor protein indicate an abundance of receptors. The PACAP38-selective antagonist PACAP 6-38 blocked trkA receptor upregulation elicited by PACAP38. The expression of epidermal growth factor receptors was not affected by PACAP38 suggesting that upregulation of trkA represents a selective effect of this neurotrophic peptide. Similarly, expression of the pan-neurotrophin binding receptor p75 was not altered by PACAP38 treatment. In addition to effects on trkA observed in wild-type PC12 cells, PACAP38 stimulated an increase in the level of expressed human trkA receptors stably transfected into PC12 cells. PACAP38 provoked an increase in basal and NGF-stimulated phosphorylation of trkA. Enhanced phosphorylation of trkA was detected as early as 6 h following addition of PACAP38 and was maximal at 48 h. Increased incorporation of phosphate occurs on both serine and tyrosine residues of trkA. These results suggest that PACAP38 is able to promote upregulation of trkA receptors, an event associated with elevated serine/tyrosine phosphorylation of trkA." @default.
- W2052051246 created "2016-06-24" @default.
- W2052051246 creator A5049332135 @default.
- W2052051246 creator A5080562741 @default.
- W2052051246 date "1999-08-01" @default.
- W2052051246 modified "2023-09-29" @default.
- W2052051246 title "Heterologous Upregulation of Nerve Growth Factor-TrkA Receptors in PC12 Cells by Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)" @default.
- W2052051246 cites W1501666754 @default.
- W2052051246 cites W1527707083 @default.
- W2052051246 cites W1972447009 @default.
- W2052051246 cites W1981423842 @default.
- W2052051246 cites W1995691579 @default.
- W2052051246 cites W2000998644 @default.
- W2052051246 cites W2009645970 @default.
- W2052051246 cites W2028563627 @default.
- W2052051246 cites W2031398528 @default.
- W2052051246 cites W2061001987 @default.
- W2052051246 cites W2063213781 @default.
- W2052051246 cites W2079743245 @default.
- W2052051246 cites W2083856782 @default.
- W2052051246 cites W2092256605 @default.
- W2052051246 cites W2092683047 @default.
- W2052051246 cites W2092862588 @default.
- W2052051246 cites W2093538032 @default.
- W2052051246 cites W2096977013 @default.
- W2052051246 cites W2099764887 @default.
- W2052051246 cites W2471847955 @default.
- W2052051246 doi "https://doi.org/10.1006/mcbr.1999.0158" @default.
- W2052051246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10542132" @default.
- W2052051246 hasPublicationYear "1999" @default.
- W2052051246 type Work @default.
- W2052051246 sameAs 2052051246 @default.
- W2052051246 citedByCount "12" @default.
- W2052051246 countsByYear W20520512462012 @default.
- W2052051246 countsByYear W20520512462014 @default.
- W2052051246 countsByYear W20520512462021 @default.
- W2052051246 countsByYear W20520512462023 @default.
- W2052051246 crossrefType "journal-article" @default.
- W2052051246 hasAuthorship W2052051246A5049332135 @default.
- W2052051246 hasAuthorship W2052051246A5080562741 @default.
- W2052051246 hasConcept C104317684 @default.
- W2052051246 hasConcept C126322002 @default.
- W2052051246 hasConcept C127561419 @default.
- W2052051246 hasConcept C134018914 @default.
- W2052051246 hasConcept C134139212 @default.
- W2052051246 hasConcept C170493617 @default.
- W2052051246 hasConcept C171034665 @default.
- W2052051246 hasConcept C185592680 @default.
- W2052051246 hasConcept C2778423431 @default.
- W2052051246 hasConcept C55493867 @default.
- W2052051246 hasConcept C56703729 @default.
- W2052051246 hasConcept C71924100 @default.
- W2052051246 hasConcept C86803240 @default.
- W2052051246 hasConcept C92020748 @default.
- W2052051246 hasConcept C95444343 @default.
- W2052051246 hasConceptScore W2052051246C104317684 @default.
- W2052051246 hasConceptScore W2052051246C126322002 @default.
- W2052051246 hasConceptScore W2052051246C127561419 @default.
- W2052051246 hasConceptScore W2052051246C134018914 @default.
- W2052051246 hasConceptScore W2052051246C134139212 @default.
- W2052051246 hasConceptScore W2052051246C170493617 @default.
- W2052051246 hasConceptScore W2052051246C171034665 @default.
- W2052051246 hasConceptScore W2052051246C185592680 @default.
- W2052051246 hasConceptScore W2052051246C2778423431 @default.
- W2052051246 hasConceptScore W2052051246C55493867 @default.
- W2052051246 hasConceptScore W2052051246C56703729 @default.
- W2052051246 hasConceptScore W2052051246C71924100 @default.
- W2052051246 hasConceptScore W2052051246C86803240 @default.
- W2052051246 hasConceptScore W2052051246C92020748 @default.
- W2052051246 hasConceptScore W2052051246C95444343 @default.
- W2052051246 hasIssue "2" @default.
- W2052051246 hasLocation W20520512461 @default.
- W2052051246 hasLocation W20520512462 @default.
- W2052051246 hasOpenAccess W2052051246 @default.
- W2052051246 hasPrimaryLocation W20520512461 @default.
- W2052051246 hasRelatedWork W2041041031 @default.
- W2052051246 hasRelatedWork W2042762326 @default.
- W2052051246 hasRelatedWork W2044214661 @default.
- W2052051246 hasRelatedWork W2047024992 @default.
- W2052051246 hasRelatedWork W2081555648 @default.
- W2052051246 hasRelatedWork W2138688715 @default.
- W2052051246 hasRelatedWork W2164406482 @default.
- W2052051246 hasRelatedWork W2495458373 @default.
- W2052051246 hasRelatedWork W3198499435 @default.
- W2052051246 hasRelatedWork W748976835 @default.
- W2052051246 hasVolume "2" @default.
- W2052051246 isParatext "false" @default.
- W2052051246 isRetracted "false" @default.
- W2052051246 magId "2052051246" @default.
- W2052051246 workType "article" @default.