Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052058216> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2052058216 endingPage "297" @default.
- W2052058216 startingPage "293" @default.
- W2052058216 abstract "Phosphoglycerate kinase (PGK), a glycolytic enzyme, possesses two isozymes: somatic-type PGK-1 and testis-specific PGK-2, encoded by distinct genes. Tissue-specific expression of the two PGK-encoding genes (Pgk) seems to be transcriptionally controlled, since tissue distribution of the mRNAs coincides well with that of the proteins. In the present study, we determined the cis-acting DNA elements that regulate the transcription of mouse Pgk-2. A transient expression assay of DNAs having various portions of the Pgk-2 upstream region linked to the chloramphenicol acetyltransferase (CAT)-encoding gene (cat) was performed using mouse cell lines that exclusively express Pgk-1. A substantial increase in cat expression was observed when the region between nucleotides (nt) −1404 and −685, relative to the most distal transcription start point at nt + 1, was lost. This cis-acting region appeared to function as a silencer, since it repressed cat expression independently of either orientation to or distance from the Pgk-2 promoter. Moreover, the cis element inhibited Pgk-2 transcription with no effect on Pgk-1 transcription in a cell-free system using nuclear extracts of rat liver. These results suggest that a silencer-like negative cis element is responsible, at least partly, for tissue-specific transcription of Pgk-2." @default.
- W2052058216 created "2016-06-24" @default.
- W2052058216 creator A5005604733 @default.
- W2052058216 creator A5041387320 @default.
- W2052058216 creator A5046646454 @default.
- W2052058216 creator A5072984532 @default.
- W2052058216 date "1992-10-01" @default.
- W2052058216 modified "2023-09-27" @default.
- W2052058216 title "A silencer-like cis element for the testis-specific phosphoglycerate-kinase-2-encoding gene" @default.
- W2052058216 cites W1925103942 @default.
- W2052058216 cites W1965258786 @default.
- W2052058216 cites W1969447026 @default.
- W2052058216 cites W1973836246 @default.
- W2052058216 cites W1978590260 @default.
- W2052058216 cites W1982598173 @default.
- W2052058216 cites W1982754765 @default.
- W2052058216 cites W1985300178 @default.
- W2052058216 cites W1986117525 @default.
- W2052058216 cites W2021169509 @default.
- W2052058216 cites W2032659124 @default.
- W2052058216 cites W2034367190 @default.
- W2052058216 cites W2035707919 @default.
- W2052058216 cites W2037164528 @default.
- W2052058216 cites W2069220973 @default.
- W2052058216 cites W2099097768 @default.
- W2052058216 cites W2103718694 @default.
- W2052058216 cites W2111224222 @default.
- W2052058216 cites W2134812217 @default.
- W2052058216 cites W2149484944 @default.
- W2052058216 cites W2990354001 @default.
- W2052058216 doi "https://doi.org/10.1016/0378-1119(92)90286-x" @default.
- W2052058216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1398112" @default.
- W2052058216 hasPublicationYear "1992" @default.
- W2052058216 type Work @default.
- W2052058216 sameAs 2052058216 @default.
- W2052058216 citedByCount "21" @default.
- W2052058216 countsByYear W20520582162014 @default.
- W2052058216 crossrefType "journal-article" @default.
- W2052058216 hasAuthorship W2052058216A5005604733 @default.
- W2052058216 hasAuthorship W2052058216A5041387320 @default.
- W2052058216 hasAuthorship W2052058216A5046646454 @default.
- W2052058216 hasAuthorship W2052058216A5072984532 @default.
- W2052058216 hasConcept C101762097 @default.
- W2052058216 hasConcept C104317684 @default.
- W2052058216 hasConcept C119795356 @default.
- W2052058216 hasConcept C132376346 @default.
- W2052058216 hasConcept C138885662 @default.
- W2052058216 hasConcept C150194340 @default.
- W2052058216 hasConcept C153911025 @default.
- W2052058216 hasConcept C155911427 @default.
- W2052058216 hasConcept C179926584 @default.
- W2052058216 hasConcept C181199279 @default.
- W2052058216 hasConcept C21592294 @default.
- W2052058216 hasConcept C2780730277 @default.
- W2052058216 hasConcept C41895202 @default.
- W2052058216 hasConcept C54355233 @default.
- W2052058216 hasConcept C55493867 @default.
- W2052058216 hasConcept C86803240 @default.
- W2052058216 hasConceptScore W2052058216C101762097 @default.
- W2052058216 hasConceptScore W2052058216C104317684 @default.
- W2052058216 hasConceptScore W2052058216C119795356 @default.
- W2052058216 hasConceptScore W2052058216C132376346 @default.
- W2052058216 hasConceptScore W2052058216C138885662 @default.
- W2052058216 hasConceptScore W2052058216C150194340 @default.
- W2052058216 hasConceptScore W2052058216C153911025 @default.
- W2052058216 hasConceptScore W2052058216C155911427 @default.
- W2052058216 hasConceptScore W2052058216C179926584 @default.
- W2052058216 hasConceptScore W2052058216C181199279 @default.
- W2052058216 hasConceptScore W2052058216C21592294 @default.
- W2052058216 hasConceptScore W2052058216C2780730277 @default.
- W2052058216 hasConceptScore W2052058216C41895202 @default.
- W2052058216 hasConceptScore W2052058216C54355233 @default.
- W2052058216 hasConceptScore W2052058216C55493867 @default.
- W2052058216 hasConceptScore W2052058216C86803240 @default.
- W2052058216 hasIssue "2" @default.
- W2052058216 hasLocation W20520582161 @default.
- W2052058216 hasLocation W20520582162 @default.
- W2052058216 hasOpenAccess W2052058216 @default.
- W2052058216 hasPrimaryLocation W20520582161 @default.
- W2052058216 hasRelatedWork W1595670287 @default.
- W2052058216 hasRelatedWork W1605643585 @default.
- W2052058216 hasRelatedWork W1772150901 @default.
- W2052058216 hasRelatedWork W1882410298 @default.
- W2052058216 hasRelatedWork W2021417144 @default.
- W2052058216 hasRelatedWork W2028666390 @default.
- W2052058216 hasRelatedWork W2042761069 @default.
- W2052058216 hasRelatedWork W2052058216 @default.
- W2052058216 hasRelatedWork W4230665539 @default.
- W2052058216 hasRelatedWork W950739481 @default.
- W2052058216 hasVolume "119" @default.
- W2052058216 isParatext "false" @default.
- W2052058216 isRetracted "false" @default.
- W2052058216 magId "2052058216" @default.
- W2052058216 workType "article" @default.