FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052071289> ?p ?o ?g. }

• W2052071289 endingPage "1397" @default.
• W2052071289 startingPage "1390" @default.
• W2052071289 abstract "Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are responsible for autosomal dominant and sporadic Parkinson disease (PD), possibly exerting their effects via a toxic gain of function. A common p.G2019S mutation (rs34637584:A>G) is responsible for up to 30–40% of PD cases in some ethnic populations. Here, we show that LRRK2 interacts with human peroxiredoxin 3 (PRDX3), a mitochondrial member of the antioxidant family of thioredoxin (Trx) peroxidases. Importantly, mutations in the LRRK2 kinase domain significantly increased phosphorylation of PRDX3 compared to wild-type. The increase in PRDX3 phosphorylation was associated with decreased peroxidase activity and increased death in LRRK2-expressing but not in LRRK2-depleted or vector-transfected neuronal cells. LRRK2 mutants stimulated mitochondrial factors involved in apoptosis and induced production of reactive oxygen species (ROS) and oxidative modification of macromolecules. Furthermore, immunoblot and immunohistochemical analysis of postmortem human PD patients carrying the p.G2019S mutation showed a marked increase in phosphorylated PRDX3 (p-PRDX3) relative to normal brain. We showed that LRRK2 mutations increase the inhibition of an endogenous peroxidase by phosphorylation promoting dysregulation of mitochondrial function and oxidative damage. Our findings provide a mechanistic link between the enhanced kinase activity of PD-linked LRRK2 and neuronal cell death. 32:1390–1397, 2011. ©2011 Wiley Periodicals, Inc." @default.
• W2052071289 created "2016-06-24" @default.
• W2052071289 creator A5009533777 @default.
• W2052071289 creator A5022481370 @default.
• W2052071289 creator A5023729531 @default.
• W2052071289 creator A5028664406 @default.
• W2052071289 creator A5050511276 @default.
• W2052071289 creator A5050824228 @default.
• W2052071289 creator A5065773926 @default.
• W2052071289 creator A5071498766 @default.
• W2052071289 creator A5075490516 @default.
• W2052071289 creator A5082606416 @default.
• W2052071289 creator A5083225635 @default.
• W2052071289 date "2011-09-12" @default.
• W2052071289 modified "2023-09-30" @default.
• W2052071289 title "Mutations in<i>LRRK2</i>increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death" @default.
• W2052071289 cites W1523775339 @default.
• W2052071289 cites W1604304380 @default.
• W2052071289 cites W1965477287 @default.
• W2052071289 cites W1968943030 @default.
• W2052071289 cites W1970848642 @default.
• W2052071289 cites W1979309046 @default.
• W2052071289 cites W1980373395 @default.
• W2052071289 cites W1996285410 @default.
• W2052071289 cites W1997673335 @default.
• W2052071289 cites W2006875797 @default.
• W2052071289 cites W2008886854 @default.
• W2052071289 cites W2017265125 @default.
• W2052071289 cites W2019006980 @default.
• W2052071289 cites W2021976306 @default.
• W2052071289 cites W2031031932 @default.
• W2052071289 cites W2037813091 @default.
• W2052071289 cites W2046623850 @default.
• W2052071289 cites W2049876918 @default.
• W2052071289 cites W2052933564 @default.
• W2052071289 cites W2055538245 @default.
• W2052071289 cites W2055979989 @default.
• W2052071289 cites W2056184839 @default.
• W2052071289 cites W2063127941 @default.
• W2052071289 cites W2075584603 @default.
• W2052071289 cites W2099677820 @default.
• W2052071289 cites W2100300726 @default.
• W2052071289 cites W2100894616 @default.
• W2052071289 cites W2109091720 @default.
• W2052071289 cites W2113282929 @default.
• W2052071289 cites W2120262230 @default.
• W2052071289 cites W2137317629 @default.
• W2052071289 cites W2154757569 @default.
• W2052071289 cites W2158511243 @default.
• W2052071289 cites W2158649740 @default.
• W2052071289 cites W37005 @default.
• W2052071289 cites W62603772 @default.
• W2052071289 doi "https://doi.org/10.1002/humu.21582" @default.
• W2052071289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21850687" @default.
• W2052071289 hasPublicationYear "2011" @default.
• W2052071289 type Work @default.
• W2052071289 sameAs 2052071289 @default.
• W2052071289 citedByCount "107" @default.
• W2052071289 countsByYear W20520712892012 @default.
• W2052071289 countsByYear W20520712892013 @default.
• W2052071289 countsByYear W20520712892014 @default.
• W2052071289 countsByYear W20520712892015 @default.
• W2052071289 countsByYear W20520712892016 @default.
• W2052071289 countsByYear W20520712892017 @default.
• W2052071289 countsByYear W20520712892018 @default.
• W2052071289 countsByYear W20520712892019 @default.
• W2052071289 countsByYear W20520712892020 @default.
• W2052071289 countsByYear W20520712892021 @default.
• W2052071289 countsByYear W20520712892022 @default.
• W2052071289 countsByYear W20520712892023 @default.
• W2052071289 crossrefType "journal-article" @default.
• W2052071289 hasAuthorship W2052071289A5009533777 @default.
• W2052071289 hasAuthorship W2052071289A5022481370 @default.
• W2052071289 hasAuthorship W2052071289A5023729531 @default.
• W2052071289 hasAuthorship W2052071289A5028664406 @default.
• W2052071289 hasAuthorship W2052071289A5050511276 @default.
• W2052071289 hasAuthorship W2052071289A5050824228 @default.
• W2052071289 hasAuthorship W2052071289A5065773926 @default.
• W2052071289 hasAuthorship W2052071289A5071498766 @default.
• W2052071289 hasAuthorship W2052071289A5075490516 @default.
• W2052071289 hasAuthorship W2052071289A5082606416 @default.
• W2052071289 hasAuthorship W2052071289A5083225635 @default.
• W2052071289 hasBestOaLocation W20520712891 @default.
• W2052071289 hasConcept C104317684 @default.
• W2052071289 hasConcept C11960822 @default.
• W2052071289 hasConcept C153911025 @default.
• W2052071289 hasConcept C162008176 @default.
• W2052071289 hasConcept C181199279 @default.
• W2052071289 hasConcept C184235292 @default.
• W2052071289 hasConcept C190283241 @default.
• W2052071289 hasConcept C2776151105 @default.
• W2052071289 hasConcept C2780416994 @default.
• W2052071289 hasConcept C2780427247 @default.
• W2052071289 hasConcept C28859421 @default.
• W2052071289 hasConcept C31573885 @default.
• W2052071289 hasConcept C3623737 @default.
• W2052071289 hasConcept C48349386 @default.
• W2052071289 hasConcept C501734568 @default.

• next