FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052076302> ?p ?o ?g. }

• W2052076302 endingPage "290" @default.
• W2052076302 startingPage "290" @default.
• W2052076302 abstract "The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was determined. The drug release and bioadhesion was dependent on type and relative amounts of the polymers. The optimized combination was subjected to in vitro antifungal activity, transmucosal permeation, drug deposition in mucosa, residence time and bioadhesion studies. IR spectroscopy was used to investigate any interaction between drug and excipients. Dissolution of miconazole from tablets was sustained for 6 h. based on the results obtained, it can be concluded that the prepared slow release buccoadhesive tablets of miconazole would markedly prolong the duration of antifungal activity. Comparison of in vitro antifungal activity of tablet with marketed gel showed that drug concentrations above the minimum inhibitory concentration were achieved immediately from both formulations but release from tablet was sustained up to 6 h, while the gel showed initially fast drug release, which did not sustain later. Drug permeation across buccal mucosa was minimum from the tablet as well as marketed gel; the deposition of drug in mucosa was higher in case of tablet. In vitro residence time and bioadhesive strength of tablet was higher than gel. Thus the buccoadhesive tablet of miconazole nitrate may offer better control of antifungal activity as compared to the gel formulation." @default.
• W2052076302 created "2016-06-24" @default.
• W2052076302 creator A5013863614 @default.
• W2052076302 creator A5042165873 @default.
• W2052076302 creator A5088183107 @default.
• W2052076302 date "2009-01-01" @default.
• W2052076302 modified "2023-09-26" @default.
• W2052076302 title "Development of buccal adhesive tablet with prolonged antifungal activity: Optimization and<i>ex vivo</i>deposition studies" @default.
• W2052076302 cites W118789076 @default.
• W2052076302 cites W188270805 @default.
• W2052076302 cites W1967418364 @default.
• W2052076302 cites W1974558951 @default.
• W2052076302 cites W1985439522 @default.
• W2052076302 cites W1998044685 @default.
• W2052076302 cites W2028311524 @default.
• W2052076302 cites W2030321529 @default.
• W2052076302 cites W2056922463 @default.
• W2052076302 cites W2130251596 @default.
• W2052076302 cites W3107271352 @default.
• W2052076302 cites W53488019 @default.
• W2052076302 cites W93597548 @default.
• W2052076302 cites W2580259330 @default.
• W2052076302 doi "https://doi.org/10.4103/0250-474x.56032" @default.
• W2052076302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2865788" @default.
• W2052076302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20490296" @default.
• W2052076302 hasPublicationYear "2009" @default.
• W2052076302 type Work @default.
• W2052076302 sameAs 2052076302 @default.
• W2052076302 citedByCount "18" @default.
• W2052076302 countsByYear W20520763022012 @default.
• W2052076302 countsByYear W20520763022013 @default.
• W2052076302 countsByYear W20520763022014 @default.
• W2052076302 countsByYear W20520763022015 @default.
• W2052076302 countsByYear W20520763022017 @default.
• W2052076302 countsByYear W20520763022020 @default.
• W2052076302 countsByYear W20520763022021 @default.
• W2052076302 countsByYear W20520763022022 @default.
• W2052076302 countsByYear W20520763022023 @default.
• W2052076302 crossrefType "journal-article" @default.
• W2052076302 hasAuthorship W2052076302A5013863614 @default.
• W2052076302 hasAuthorship W2052076302A5042165873 @default.
• W2052076302 hasAuthorship W2052076302A5088183107 @default.
• W2052076302 hasBestOaLocation W20520763022 @default.
• W2052076302 hasConcept C159985019 @default.
• W2052076302 hasConcept C16005928 @default.
• W2052076302 hasConcept C178790620 @default.
• W2052076302 hasConcept C185592680 @default.
• W2052076302 hasConcept C192562407 @default.
• W2052076302 hasConcept C195735259 @default.
• W2052076302 hasConcept C202751555 @default.
• W2052076302 hasConcept C26291073 @default.
• W2052076302 hasConcept C2776634624 @default.
• W2052076302 hasConcept C2777229883 @default.
• W2052076302 hasConcept C2778540859 @default.
• W2052076302 hasConcept C2779548794 @default.
• W2052076302 hasConcept C2779820397 @default.
• W2052076302 hasConcept C2780020223 @default.
• W2052076302 hasConcept C2911222091 @default.
• W2052076302 hasConcept C2991737395 @default.
• W2052076302 hasConcept C41625074 @default.
• W2052076302 hasConcept C43617362 @default.
• W2052076302 hasConcept C50670333 @default.
• W2052076302 hasConcept C55493867 @default.
• W2052076302 hasConcept C71924100 @default.
• W2052076302 hasConcept C98274493 @default.
• W2052076302 hasConceptScore W2052076302C159985019 @default.
• W2052076302 hasConceptScore W2052076302C16005928 @default.
• W2052076302 hasConceptScore W2052076302C178790620 @default.
• W2052076302 hasConceptScore W2052076302C185592680 @default.
• W2052076302 hasConceptScore W2052076302C192562407 @default.
• W2052076302 hasConceptScore W2052076302C195735259 @default.
• W2052076302 hasConceptScore W2052076302C202751555 @default.
• W2052076302 hasConceptScore W2052076302C26291073 @default.
• W2052076302 hasConceptScore W2052076302C2776634624 @default.
• W2052076302 hasConceptScore W2052076302C2777229883 @default.
• W2052076302 hasConceptScore W2052076302C2778540859 @default.
• W2052076302 hasConceptScore W2052076302C2779548794 @default.
• W2052076302 hasConceptScore W2052076302C2779820397 @default.
• W2052076302 hasConceptScore W2052076302C2780020223 @default.
• W2052076302 hasConceptScore W2052076302C2911222091 @default.
• W2052076302 hasConceptScore W2052076302C2991737395 @default.
• W2052076302 hasConceptScore W2052076302C41625074 @default.
• W2052076302 hasConceptScore W2052076302C43617362 @default.
• W2052076302 hasConceptScore W2052076302C50670333 @default.
• W2052076302 hasConceptScore W2052076302C55493867 @default.
• W2052076302 hasConceptScore W2052076302C71924100 @default.
• W2052076302 hasConceptScore W2052076302C98274493 @default.
• W2052076302 hasIssue "3" @default.
• W2052076302 hasLocation W20520763021 @default.
• W2052076302 hasLocation W20520763022 @default.
• W2052076302 hasLocation W20520763023 @default.
• W2052076302 hasLocation W20520763024 @default.
• W2052076302 hasOpenAccess W2052076302 @default.
• W2052076302 hasPrimaryLocation W20520763021 @default.
• W2052076302 hasRelatedWork W1985439522 @default.
• W2052076302 hasRelatedWork W2031628236 @default.
• W2052076302 hasRelatedWork W2034377127 @default.
• W2052076302 hasRelatedWork W2052076302 @default.

• next