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- W2052076501 abstract "Lopez-Barahona et al. report in this issue the differential regulation of beta-1 adrenergic receptor (β1-AR) gene expression by thyroid hormones in myocytes and C6 glioma cells. They found that triiodothyronine (T3) regulates β1-AR in myocytes but not in C6 glioma cells. Because the T3 binding capacity and the levels of thyroid hormone receptor (TR) mRNAs are low in C6 glioma cells, they have overexpressed TRα1 in order to determine whether increased levels of TRs would increase the sensitivity of these cells to T3. Although TRα1 was functional in transfected cells, no effect of T3 was observed on β1-AR gene expression. These data suggest cell-specific regulation of gene expression by thyroid hormones and raise the important question about the mechanisms that underlie the cellular specificity in the action of thyroid hormones." @default.
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- W2052076501 date "1996-12-01" @default.
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- W2052076501 title "Thyroid hormone receptors are necessary but not sufficient for transcription" @default.
- W2052076501 doi "https://doi.org/10.1530/eje.0.1350651" @default.
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