FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052079689> ?p ?o ?g. }

• W2052079689 endingPage "e54879" @default.
• W2052079689 startingPage "e54879" @default.
• W2052079689 abstract "The dendritic cell (DC) coordinates innate and adaptive immunity to fight infections and cancer. Our observations reveal that DCs exposed to the microbial danger signal lipopolysaccharide (LPS) in the presence of interferon-γ (IFN-γ) acquire a continuously changing activation/maturation phenotype. The DCs' initial mode of action is pro-inflammatory via up-regulation among others of the signaling molecule interleukin (IL) 12, which polarizes IFN-γ secreting type 1 helper T-cells (Th1). Within 24 hours the same DC switches from the pro- into an anti-inflammatory phenotype. This is mediated by autocrine IL-10 release and secretion of soluble IL-2 receptor alpha (sIL-2RA) molecules. T-cells, when contacted with DCs during their anti-inflammatory phase loose their proliferative capacity and develop regulatory T-cell (Treg) -like anti-inflammatory functions indicated by IL-10 secretion and elevated FoxP3 levels. Studying the kinetics of IL-12 and IL-10 expression from LPS/IFN-γ activated myeloid DCs on a single cell level confirmed these observations. When T-cells are separated from DCs within 24 hours, they are spared from the anti-inflammatory DC activity. We conclude that, in addition to differentiation of DCs into distinct subsets, the observed sequential functional phases of DC differentiation permit the fine-tuning of an immune response. A better understanding of time-kinetic DC features is required for optimally exploiting the therapeutic capacity of DCs in cancer immune therapy." @default.
• W2052079689 created "2016-06-24" @default.
• W2052079689 creator A5025785324 @default.
• W2052079689 creator A5029964731 @default.
• W2052079689 creator A5034343186 @default.
• W2052079689 creator A5052257966 @default.
• W2052079689 creator A5053027723 @default.
• W2052079689 creator A5070281060 @default.
• W2052079689 date "2013-02-11" @default.
• W2052079689 modified "2023-09-23" @default.
• W2052079689 title "Toll-Like Receptor 4 Engagement Drives Differentiation of Human and Murine Dendritic Cells from a Pro- into an Anti-Inflammatory Mode" @default.
• W2052079689 cites W1488377901 @default.
• W2052079689 cites W1501518736 @default.
• W2052079689 cites W1669165205 @default.
• W2052079689 cites W1678167583 @default.
• W2052079689 cites W1974489349 @default.
• W2052079689 cites W1977190145 @default.
• W2052079689 cites W1988009411 @default.
• W2052079689 cites W1991459661 @default.
• W2052079689 cites W1994793499 @default.
• W2052079689 cites W1997322438 @default.
• W2052079689 cites W1997337311 @default.
• W2052079689 cites W1999511070 @default.
• W2052079689 cites W2002225831 @default.
• W2052079689 cites W2004630197 @default.
• W2052079689 cites W2012426855 @default.
• W2052079689 cites W2015776459 @default.
• W2052079689 cites W2023272220 @default.
• W2052079689 cites W2023567649 @default.
• W2052079689 cites W2034866848 @default.
• W2052079689 cites W2038550540 @default.
• W2052079689 cites W2047990158 @default.
• W2052079689 cites W2052065441 @default.
• W2052079689 cites W2054554990 @default.
• W2052079689 cites W2059568505 @default.
• W2052079689 cites W2067147062 @default.
• W2052079689 cites W2077405407 @default.
• W2052079689 cites W2078450673 @default.
• W2052079689 cites W2082099294 @default.
• W2052079689 cites W2098267542 @default.
• W2052079689 cites W2106684817 @default.
• W2052079689 cites W2110651507 @default.
• W2052079689 cites W2111253388 @default.
• W2052079689 cites W2115855421 @default.
• W2052079689 cites W2116407378 @default.
• W2052079689 cites W2119939110 @default.
• W2052079689 cites W2123049876 @default.
• W2052079689 cites W2128321311 @default.
• W2052079689 cites W2129932872 @default.
• W2052079689 cites W2131761283 @default.
• W2052079689 cites W2134080373 @default.
• W2052079689 cites W2139501738 @default.
• W2052079689 cites W2140944306 @default.
• W2052079689 cites W2142808962 @default.
• W2052079689 cites W2145736817 @default.
• W2052079689 cites W2148953720 @default.
• W2052079689 cites W2155927405 @default.
• W2052079689 cites W2160792462 @default.
• W2052079689 cites W2164351607 @default.
• W2052079689 cites W2783142245 @default.
• W2052079689 doi "https://doi.org/10.1371/journal.pone.0054879" @default.
• W2052079689 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3569454" @default.
• W2052079689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23408948" @default.
• W2052079689 hasPublicationYear "2013" @default.
• W2052079689 type Work @default.
• W2052079689 sameAs 2052079689 @default.
• W2052079689 citedByCount "24" @default.
• W2052079689 countsByYear W20520796892013 @default.
• W2052079689 countsByYear W20520796892014 @default.
• W2052079689 countsByYear W20520796892015 @default.
• W2052079689 countsByYear W20520796892016 @default.
• W2052079689 countsByYear W20520796892018 @default.
• W2052079689 countsByYear W20520796892019 @default.
• W2052079689 countsByYear W20520796892020 @default.
• W2052079689 countsByYear W20520796892021 @default.
• W2052079689 countsByYear W20520796892022 @default.
• W2052079689 crossrefType "journal-article" @default.
• W2052079689 hasAuthorship W2052079689A5025785324 @default.
• W2052079689 hasAuthorship W2052079689A5029964731 @default.
• W2052079689 hasAuthorship W2052079689A5034343186 @default.
• W2052079689 hasAuthorship W2052079689A5052257966 @default.
• W2052079689 hasAuthorship W2052079689A5053027723 @default.
• W2052079689 hasAuthorship W2052079689A5070281060 @default.
• W2052079689 hasBestOaLocation W20520796891 @default.
• W2052079689 hasConcept C128240485 @default.
• W2052079689 hasConcept C136449434 @default.
• W2052079689 hasConcept C170493617 @default.
• W2052079689 hasConcept C193419808 @default.
• W2052079689 hasConcept C203014093 @default.
• W2052079689 hasConcept C2776090121 @default.
• W2052079689 hasConcept C2776709828 @default.
• W2052079689 hasConcept C2776914184 @default.
• W2052079689 hasConcept C2777701055 @default.
• W2052079689 hasConcept C2778170410 @default.
• W2052079689 hasConcept C2779727006 @default.
• W2052079689 hasConcept C2780674031 @default.
• W2052079689 hasConcept C49039625 @default.
• W2052079689 hasConcept C55493867 @default.

• next