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• W2052087965 abstract "Narcolepsy is a sleep disorder emerging in early adulthood on an HLA-related genetic background. Through unresolved pathways, involving the destruction or silencing of specific cells in the lateral hypothalamus, a deficiency of orexin production occurs. An autoimmune process targeting orexin-producing cells may cause acquired orexin deficiency. Abnormalities in cytokine production reported in narcolepsy unspecifically support this idea, but empirical evidence for a causative role of immunopathology is lacking. Orexin deficiency affects neuroendocrine and neurotransmitter systems leading to reduced stability of and/or disturbed transitions between wakefulness, REM, and nonREM sleep. However, narcolepsy is rather a complex neuroendocrine disorder rather than a pure sleep disorder because orexin deficiency induces endocrine and metabolic disturbances such as obesity and diabetes." @default.
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• W2052087965 date "2007-06-01" @default.
• W2052087965 modified "2023-09-27" @default.
• W2052087965 title "Immunoendocrine Abnormalities in Narcolepsy" @default.
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• W2052087965 doi "https://doi.org/10.1016/j.jsmc.2007.03.002" @default.
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