FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052097079> ?p ?o ?g. }

• W2052097079 endingPage "143" @default.
• W2052097079 startingPage "135" @default.
• W2052097079 abstract "Protease-activated receptor 1 (PAR1) that can be activated by serine proteinases such as thrombin has been demonstrated to contribute to the development of cardiac remodeling and hypertrophy after myocardial injury. Here, we investigated the mechanisms by which PAR1 leads to hypertrophic cardiomyocyte growth using cultured rat neonatal ventricular myocytes. PAR1 stimulation with thrombin (1 U/ml) or a synthetic agonist peptide (TFLLR-NH2, 50 μM) for 48 h induced an increase in cell size and myofibril formation associated with BNP (brain natriuretic peptide) production. This actin reorganization assessed by fluorescein isothiocyanate (FITC)-conjugated phalloidin staining appeared at 1 h after PAR1 stimulation, and this response was reduced by a protein kinase C (PKC) inhibitor, chelerythrine, inhibitors of Rho (simvastatin) and Rho-associated kinase (ROCK) (Y-27632), but not by pertussis toxin (PTX). By Western blot analysis, translocation of PKCα or PKCε from the cytosol to membrane fractions was observed in cells stimulated with thrombin or TFLLR-NH2 for 2 – 5 min. In addition, PAR1 stimulation for 3 – 5 min increased the level of active RhoA. Furthermore, inhibitors of PKC and ROCK and Rho abrogated PAR1-mediated increase in cell size. Depletion of PKCα or PKCε by specific small interfering RNA also suppressed both actin reorganization and cell growth. These results suggest that PAR1 stimulation of cardiomyocytes induces cell hypertrophy with actin cytoskeletal reorganization through activation of PKCα and PKCε isoforms and RhoA via PTX-insensitive G proteins." @default.
• W2052097079 created "2016-06-24" @default.
• W2052097079 creator A5001672446 @default.
• W2052097079 creator A5029431318 @default.
• W2052097079 creator A5046684955 @default.
• W2052097079 creator A5050276095 @default.
• W2052097079 creator A5074874465 @default.
• W2052097079 date "2011-01-01" @default.
• W2052097079 modified "2023-10-05" @default.
• W2052097079 title "Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1–Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes" @default.
• W2052097079 cites W1485533681 @default.
• W2052097079 cites W1965221121 @default.
• W2052097079 cites W1974734628 @default.
• W2052097079 cites W1980263300 @default.
• W2052097079 cites W1986587815 @default.
• W2052097079 cites W1987232348 @default.
• W2052097079 cites W2007610433 @default.
• W2052097079 cites W2020456690 @default.
• W2052097079 cites W2022390033 @default.
• W2052097079 cites W2044580150 @default.
• W2052097079 cites W2047389827 @default.
• W2052097079 cites W2049192110 @default.
• W2052097079 cites W2052167458 @default.
• W2052097079 cites W2052926928 @default.
• W2052097079 cites W2055714965 @default.
• W2052097079 cites W2056801995 @default.
• W2052097079 cites W2066020583 @default.
• W2052097079 cites W2066116350 @default.
• W2052097079 cites W2099256348 @default.
• W2052097079 cites W2101433052 @default.
• W2052097079 cites W2110540881 @default.
• W2052097079 cites W2128304515 @default.
• W2052097079 cites W2137995905 @default.
• W2052097079 cites W2138203081 @default.
• W2052097079 cites W2147501143 @default.
• W2052097079 cites W2163946154 @default.
• W2052097079 cites W2165541514 @default.
• W2052097079 cites W2168168058 @default.
• W2052097079 cites W2168844674 @default.
• W2052097079 cites W2170850197 @default.
• W2052097079 cites W22787660 @default.
• W2052097079 cites W2402936010 @default.
• W2052097079 doi "https://doi.org/10.1254/jphs.10197fp" @default.
• W2052097079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32272531" @default.
• W2052097079 hasPublicationYear "2011" @default.
• W2052097079 type Work @default.
• W2052097079 sameAs 2052097079 @default.
• W2052097079 citedByCount "22" @default.
• W2052097079 countsByYear W20520970792012 @default.
• W2052097079 countsByYear W20520970792013 @default.
• W2052097079 countsByYear W20520970792015 @default.
• W2052097079 countsByYear W20520970792016 @default.
• W2052097079 countsByYear W20520970792018 @default.
• W2052097079 countsByYear W20520970792019 @default.
• W2052097079 countsByYear W20520970792020 @default.
• W2052097079 countsByYear W20520970792021 @default.
• W2052097079 countsByYear W20520970792022 @default.
• W2052097079 crossrefType "journal-article" @default.
• W2052097079 hasAuthorship W2052097079A5001672446 @default.
• W2052097079 hasAuthorship W2052097079A5029431318 @default.
• W2052097079 hasAuthorship W2052097079A5046684955 @default.
• W2052097079 hasAuthorship W2052097079A5050276095 @default.
• W2052097079 hasAuthorship W2052097079A5074874465 @default.
• W2052097079 hasBestOaLocation W20520970791 @default.
• W2052097079 hasConcept C142669718 @default.
• W2052097079 hasConcept C1491633281 @default.
• W2052097079 hasConcept C153911025 @default.
• W2052097079 hasConcept C185592680 @default.
• W2052097079 hasConcept C195794163 @default.
• W2052097079 hasConcept C201800478 @default.
• W2052097079 hasConcept C2776108454 @default.
• W2052097079 hasConcept C2776601116 @default.
• W2052097079 hasConcept C2777093181 @default.
• W2052097079 hasConcept C2778769476 @default.
• W2052097079 hasConcept C2993400109 @default.
• W2052097079 hasConcept C49773422 @default.
• W2052097079 hasConcept C55493867 @default.
• W2052097079 hasConcept C62478195 @default.
• W2052097079 hasConcept C80631254 @default.
• W2052097079 hasConcept C86803240 @default.
• W2052097079 hasConcept C95444343 @default.
• W2052097079 hasConceptScore W2052097079C142669718 @default.
• W2052097079 hasConceptScore W2052097079C1491633281 @default.
• W2052097079 hasConceptScore W2052097079C153911025 @default.
• W2052097079 hasConceptScore W2052097079C185592680 @default.
• W2052097079 hasConceptScore W2052097079C195794163 @default.
• W2052097079 hasConceptScore W2052097079C201800478 @default.
• W2052097079 hasConceptScore W2052097079C2776108454 @default.
• W2052097079 hasConceptScore W2052097079C2776601116 @default.
• W2052097079 hasConceptScore W2052097079C2777093181 @default.
• W2052097079 hasConceptScore W2052097079C2778769476 @default.
• W2052097079 hasConceptScore W2052097079C2993400109 @default.
• W2052097079 hasConceptScore W2052097079C49773422 @default.
• W2052097079 hasConceptScore W2052097079C55493867 @default.
• W2052097079 hasConceptScore W2052097079C62478195 @default.
• W2052097079 hasConceptScore W2052097079C80631254 @default.
• W2052097079 hasConceptScore W2052097079C86803240 @default.
• W2052097079 hasConceptScore W2052097079C95444343 @default.

• next