FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052103695> ?p ?o ?g. }

• W2052103695 endingPage "130" @default.
• W2052103695 startingPage "120" @default.
• W2052103695 abstract "Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue injury.Immunohistochemistry for DAF and C3 and nonradioactive in situ hybridization with digoxigenin-labeled oligonucleotide probe for DAF and C3 mRNA were performed in 22 tissue samples of kidneys from patients with IgA nephropathy (IgAN), 6 with membranous nephropathy (MN), 6 with lupus nephritis (LN), and five normal kidneys.In the normal kidney, DAF was confined to the juxtaglomerular apparatus and little or no C3 was detected; however, a few glomerular cells were positive for DAF mRNA but no C3 mRNA positive cells were detected. In diseased kidneys, DAF and C3 as well as their mRNAs were detected in mesangial cells, tubular cells and infiltrating cells. Glomerular epithelial cells and Bowman's capsule cells contained little or no DAF and C3 but were positive for their mRNAs. The mean percentages of mesangial cells positive for DAF and C3 mRNAs were 49.3 +/- 11.5% and 50.7 +/- 10.3% in IgAN, and 17.0 +/- 6.3% and 19.4 +/- 9.0% in MN, respectively. The percentage of mesangial cells positive for DAF and C3 mRNAs among intraglomerular cells correlated positively with the degree of mesangial proliferation and glomerular sclerosis in IgAN. In contrast, in LN the percentage of glomerular cells positive for DAF mRNA correlated negatively with the degree of glomerular injury, while the percentage of cells positive for C3 mRNA did not change with the progression of the disease. The ratio of C3 mRNA/DAF mRNA of glomerular cells correlated with the degree of glomerular injury in both IgAN and LN. In the tubulointerstitium, the percentage of cells expressing mRNA, and C3 mRNA/DAF mRNA radio correlated with the degree of tubular atrophy and interstitial broadening in both IgAN and LN.We conclude that DAF and C3 mRNAs are synthesized in human diseased kidneys, and that a balance between locally synthesized DAF and C3 may be important in the progression of glomerulonephritis." @default.
• W2052103695 created "2016-06-24" @default.
• W2052103695 creator A5006762904 @default.
• W2052103695 creator A5022994254 @default.
• W2052103695 creator A5024088462 @default.
• W2052103695 creator A5025902898 @default.
• W2052103695 creator A5042343167 @default.
• W2052103695 creator A5042810491 @default.
• W2052103695 creator A5069038207 @default.
• W2052103695 creator A5072661393 @default.
• W2052103695 creator A5086116258 @default.
• W2052103695 date "1998-07-01" @default.
• W2052103695 modified "2023-10-15" @default.
• W2052103695 title "Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney" @default.
• W2052103695 cites W1598814826 @default.
• W2052103695 cites W1872408728 @default.
• W2052103695 cites W1968659516 @default.
• W2052103695 cites W1969255683 @default.
• W2052103695 cites W1983210873 @default.
• W2052103695 cites W1985918311 @default.
• W2052103695 cites W1990943556 @default.
• W2052103695 cites W1995431039 @default.
• W2052103695 cites W2001579563 @default.
• W2052103695 cites W2002583455 @default.
• W2052103695 cites W2003836506 @default.
• W2052103695 cites W2005328294 @default.
• W2052103695 cites W2007463241 @default.
• W2052103695 cites W2013984551 @default.
• W2052103695 cites W2022460432 @default.
• W2052103695 cites W2025123467 @default.
• W2052103695 cites W2025412732 @default.
• W2052103695 cites W2030471723 @default.
• W2052103695 cites W2030572845 @default.
• W2052103695 cites W2031075440 @default.
• W2052103695 cites W2031313148 @default.
• W2052103695 cites W2042176520 @default.
• W2052103695 cites W2049939760 @default.
• W2052103695 cites W2055858339 @default.
• W2052103695 cites W2059300566 @default.
• W2052103695 cites W2066834432 @default.
• W2052103695 cites W2070881821 @default.
• W2052103695 cites W2081094803 @default.
• W2052103695 cites W2083127403 @default.
• W2052103695 cites W2088737496 @default.
• W2052103695 cites W2093099941 @default.
• W2052103695 cites W2094698265 @default.
• W2052103695 cites W2123994245 @default.
• W2052103695 cites W2147514700 @default.
• W2052103695 cites W2221985227 @default.
• W2052103695 cites W2305495182 @default.
• W2052103695 cites W2339597902 @default.
• W2052103695 cites W2418328677 @default.
• W2052103695 doi "https://doi.org/10.1046/j.1523-1755.1998.00961.x" @default.
• W2052103695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9648070" @default.
• W2052103695 hasPublicationYear "1998" @default.
• W2052103695 type Work @default.
• W2052103695 sameAs 2052103695 @default.
• W2052103695 citedByCount "45" @default.
• W2052103695 countsByYear W20521036952013 @default.
• W2052103695 countsByYear W20521036952014 @default.
• W2052103695 countsByYear W20521036952015 @default.
• W2052103695 countsByYear W20521036952017 @default.
• W2052103695 countsByYear W20521036952018 @default.
• W2052103695 countsByYear W20521036952020 @default.
• W2052103695 countsByYear W20521036952021 @default.
• W2052103695 countsByYear W20521036952022 @default.
• W2052103695 crossrefType "journal-article" @default.
• W2052103695 hasAuthorship W2052103695A5006762904 @default.
• W2052103695 hasAuthorship W2052103695A5022994254 @default.
• W2052103695 hasAuthorship W2052103695A5024088462 @default.
• W2052103695 hasAuthorship W2052103695A5025902898 @default.
• W2052103695 hasAuthorship W2052103695A5042343167 @default.
• W2052103695 hasAuthorship W2052103695A5042810491 @default.
• W2052103695 hasAuthorship W2052103695A5069038207 @default.
• W2052103695 hasAuthorship W2052103695A5072661393 @default.
• W2052103695 hasAuthorship W2052103695A5086116258 @default.
• W2052103695 hasBestOaLocation W20521036951 @default.
• W2052103695 hasConcept C104317684 @default.
• W2052103695 hasConcept C105580179 @default.
• W2052103695 hasConcept C111684460 @default.
• W2052103695 hasConcept C126322002 @default.
• W2052103695 hasConcept C134018914 @default.
• W2052103695 hasConcept C153911025 @default.
• W2052103695 hasConcept C185592680 @default.
• W2052103695 hasConcept C203014093 @default.
• W2052103695 hasConcept C2779134260 @default.
• W2052103695 hasConcept C2779912601 @default.
• W2052103695 hasConcept C2780091579 @default.
• W2052103695 hasConcept C2780368995 @default.
• W2052103695 hasConcept C2781184683 @default.
• W2052103695 hasConcept C3018920779 @default.
• W2052103695 hasConcept C55493867 @default.
• W2052103695 hasConcept C555293320 @default.
• W2052103695 hasConcept C71924100 @default.
• W2052103695 hasConcept C81439078 @default.
• W2052103695 hasConcept C8487232 @default.
• W2052103695 hasConcept C86803240 @default.
• W2052103695 hasConcept C8891405 @default.

• next