FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052108057> ?p ?o ?g. }

• W2052108057 endingPage "390" @default.
• W2052108057 startingPage "369" @default.
• W2052108057 abstract "Retinal degeneration in rd mice is manifested during the most rapid period of postnatal photoreceptor differentiation and is hypothesized to be caused by a lesion in cGMP metabolism. We have studied the sequence of developmental expression of three proteins involved in the cGMP cascade and the mRNAs from which they are translated, in rd and control mouse retinas. Slot blot analysis of retinal RNAs indicates that the mRNAs coding for opsin, the α, β and γ subunits of G-protein and 48-kDa protein each has the same time for onset of expression in normal and diseased retinas. Gβ and 48-kDa protein mRNAs are already detectable at birth, opsin mRNA appears by postnatal day 5 (P5), Gγ mRNA at P6 and Gα mRNA by P8. The levels of all these mRNAs decrease in the diseased retinas after P11–P12, correlating with the reduction in photoreceptor cell number that characterizes the rd disease. Immunocytochemistry indicates that the 48-kDa protein is present at birth, Gγ and opsin are detectable at P4 and Gα at P7. After P7, opsin and G-protein immunoreactivity are localized throughout the photoreceptor cell in the rd retinas but they are found only in the outer segment in control retinas. The 48-kDa protein immunoreactivity, which is observed in the whole photoreceptor layer both in rd and control retinas throughout development, is the only one of all immunoreactivities analysed that remains at 2 months of age in the rd retina and is probably localized in cones. However, at 6 months of age, 48-kDa protein immunoreactive cells are no longer present in the rd retina. We have also investigated whether there is a daily rhythm for the levels of mRNA present at different times during the light/dark periods in developing rdrd and rd/+ retinas and in adult normal (+/+) retinas. We find that the levels of each mRNA analysed appear to cycle in the +/+ adult retina, with the greatest amount of opsin and the three subunits of G-protein mRNAs occurring just before light onset and the greatest amount of 48-kDa protein mRNA occurring just before lights off. Cycling in the developing diseased or control retinas (P0–P12) is not observed and may be masked by the pronounced cell growth that occurs during this period." @default.
• W2052108057 created "2016-06-24" @default.
• W2052108057 creator A5005767794 @default.
• W2052108057 creator A5025653539 @default.
• W2052108057 creator A5074735332 @default.
• W2052108057 date "1988-09-01" @default.
• W2052108057 modified "2023-10-12" @default.
• W2052108057 title "Opsin, G-protein and 48-kDa protein in normal and rd mouse retinas: Developmental expression of mRNAS and proteins and light/dark cycling of mRNAs" @default.
• W2052108057 cites W1014800282 @default.
• W2052108057 cites W1483634733 @default.
• W2052108057 cites W1963591622 @default.
• W2052108057 cites W1968338512 @default.
• W2052108057 cites W1968901334 @default.
• W2052108057 cites W1987834587 @default.
• W2052108057 cites W1994152829 @default.
• W2052108057 cites W2000115325 @default.
• W2052108057 cites W2001488073 @default.
• W2052108057 cites W2011820509 @default.
• W2052108057 cites W2014669590 @default.
• W2052108057 cites W2028803712 @default.
• W2052108057 cites W2051747007 @default.
• W2052108057 cites W2060333964 @default.
• W2052108057 cites W2061792771 @default.
• W2052108057 cites W2085801794 @default.
• W2052108057 cites W2088909888 @default.
• W2052108057 cites W2089559975 @default.
• W2052108057 cites W2091850212 @default.
• W2052108057 cites W2092489342 @default.
• W2052108057 cites W2144704200 @default.
• W2052108057 doi "https://doi.org/10.1016/0014-4835(88)90049-8" @default.
• W2052108057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2846333" @default.
• W2052108057 hasPublicationYear "1988" @default.
• W2052108057 type Work @default.
• W2052108057 sameAs 2052108057 @default.
• W2052108057 citedByCount "147" @default.
• W2052108057 countsByYear W20521080572012 @default.
• W2052108057 countsByYear W20521080572013 @default.
• W2052108057 countsByYear W20521080572014 @default.
• W2052108057 countsByYear W20521080572015 @default.
• W2052108057 countsByYear W20521080572016 @default.
• W2052108057 countsByYear W20521080572017 @default.
• W2052108057 countsByYear W20521080572019 @default.
• W2052108057 countsByYear W20521080572020 @default.
• W2052108057 countsByYear W20521080572022 @default.
• W2052108057 countsByYear W20521080572023 @default.
• W2052108057 crossrefType "journal-article" @default.
• W2052108057 hasAuthorship W2052108057A5005767794 @default.
• W2052108057 hasAuthorship W2052108057A5025653539 @default.
• W2052108057 hasAuthorship W2052108057A5074735332 @default.
• W2052108057 hasConcept C104317684 @default.
• W2052108057 hasConcept C105580179 @default.
• W2052108057 hasConcept C134018914 @default.
• W2052108057 hasConcept C150194340 @default.
• W2052108057 hasConcept C153911025 @default.
• W2052108057 hasConcept C169760540 @default.
• W2052108057 hasConcept C202033177 @default.
• W2052108057 hasConcept C2777093970 @default.
• W2052108057 hasConcept C2780827179 @default.
• W2052108057 hasConcept C2780916184 @default.
• W2052108057 hasConcept C2781040256 @default.
• W2052108057 hasConcept C30028475 @default.
• W2052108057 hasConcept C35866371 @default.
• W2052108057 hasConcept C55493867 @default.
• W2052108057 hasConcept C86803240 @default.
• W2052108057 hasConcept C95444343 @default.
• W2052108057 hasConceptScore W2052108057C104317684 @default.
• W2052108057 hasConceptScore W2052108057C105580179 @default.
• W2052108057 hasConceptScore W2052108057C134018914 @default.
• W2052108057 hasConceptScore W2052108057C150194340 @default.
• W2052108057 hasConceptScore W2052108057C153911025 @default.
• W2052108057 hasConceptScore W2052108057C169760540 @default.
• W2052108057 hasConceptScore W2052108057C202033177 @default.
• W2052108057 hasConceptScore W2052108057C2777093970 @default.
• W2052108057 hasConceptScore W2052108057C2780827179 @default.
• W2052108057 hasConceptScore W2052108057C2780916184 @default.
• W2052108057 hasConceptScore W2052108057C2781040256 @default.
• W2052108057 hasConceptScore W2052108057C30028475 @default.
• W2052108057 hasConceptScore W2052108057C35866371 @default.
• W2052108057 hasConceptScore W2052108057C55493867 @default.
• W2052108057 hasConceptScore W2052108057C86803240 @default.
• W2052108057 hasConceptScore W2052108057C95444343 @default.
• W2052108057 hasIssue "3" @default.
• W2052108057 hasLocation W20521080571 @default.
• W2052108057 hasLocation W20521080572 @default.
• W2052108057 hasOpenAccess W2052108057 @default.
• W2052108057 hasPrimaryLocation W20521080571 @default.
• W2052108057 hasRelatedWork W101883115 @default.
• W2052108057 hasRelatedWork W1542042880 @default.
• W2052108057 hasRelatedWork W2009477947 @default.
• W2052108057 hasRelatedWork W2053743890 @default.
• W2052108057 hasRelatedWork W2083948106 @default.
• W2052108057 hasRelatedWork W2094612773 @default.
• W2052108057 hasRelatedWork W2102549296 @default.
• W2052108057 hasRelatedWork W2115104922 @default.
• W2052108057 hasRelatedWork W2804796581 @default.
• W2052108057 hasRelatedWork W36884569 @default.
• W2052108057 hasVolume "47" @default.
• W2052108057 isParatext "false" @default.

• next