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• W2052113971 endingPage "424" @default.
• W2052113971 startingPage "415" @default.
• W2052113971 abstract "Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus." @default.
• W2052113971 created "2016-06-24" @default.
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• W2052113971 date "2015-06-01" @default.
• W2052113971 modified "2023-09-26" @default.
• W2052113971 title "The Effect of Proton Pump Inhibitors on Barrett’s Esophagus" @default.
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• W2052113971 doi "https://doi.org/10.1016/j.gtc.2015.02.010" @default.
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