FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052118204> ?p ?o ?g. }

• W2052118204 endingPage "131" @default.
• W2052118204 startingPage "125" @default.
• W2052118204 abstract "Oxidative stress may play a relevant role in synovial inflammation and subsequently on cartilage damage during osteoarthritis development. We have assessed how the antioxidant N-acetylcysteine (NAC) affects the expression of different proinflammatory and structural mediators in human stimulated osteoarthritic synoviocytes and chondrocytes. Synovial membrane and articular cartilage were obtained from the osteoarthritis knees of patients who underwent joint replacement surgery. In cells stimulated with IL-1beta (10U/mL), the effects of NAC (2mmol/L) were tested at the mean peak plasma level following oral administration of therapeutic doses and its influence on prostaglandin E2 (PGE(2)) production, cyclooxigenase-2 (COX-2) expression, nitric oxide (NO) synthesis, nuclear factor kappa B (NF-kappaB) activation, and metalloproteinase-1 (MMP-1) and metalloproteinase-13 (MMP-13) expression were evaluated. While NAC significantly diminished PGE(2) release and the expression of both COX-2 and MMP-13 protein in IL-1beta-stimulated synoviocytes, it failed to modify their production in stimulated chondrocytes. Likewise, NAC only inhibited IL-1beta-stimulated NF-kappaB activation in synoviocytes. No inhibition of IL-1beta-induced NO synthesis by chondrocytes was observed following NAC incubation, while synoviocytes did not release detectable levels of NO. NAC did not induce changes in MMP-1 protein expression in either IL-1beta-stimulated synoviocytes or chondrocytes. Thus, NAC decreases the synthesis of several catabolic mediators by osteoarthritic synoviocytes, whereas, it failed to produce the same effects in osteoarthritic chondrocytes. Our results suggest that NAC inhibits some oxygen-dependent mechanisms in synoviocytes but not in chondrocytes during osteoarthritis. Therefore, NAC might have a symptomatic effect on the synovium rather than a structural effect on the cartilage in osteoarthritis." @default.
• W2052118204 created "2016-06-24" @default.
• W2052118204 creator A5012858626 @default.
• W2052118204 creator A5020670005 @default.
• W2052118204 creator A5023683621 @default.
• W2052118204 creator A5025513759 @default.
• W2052118204 creator A5030908141 @default.
• W2052118204 creator A5089589231 @default.
• W2052118204 date "2009-11-01" @default.
• W2052118204 modified "2023-10-17" @default.
• W2052118204 title "Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in IL-1β-stimulated human osteoarthritic synoviocytes and chondrocytes" @default.
• W2052118204 cites W1538765821 @default.
• W2052118204 cites W1812173421 @default.
• W2052118204 cites W1965435354 @default.
• W2052118204 cites W1976164614 @default.
• W2052118204 cites W1980755508 @default.
• W2052118204 cites W1986501867 @default.
• W2052118204 cites W1988424962 @default.
• W2052118204 cites W1991952977 @default.
• W2052118204 cites W2003519759 @default.
• W2052118204 cites W2010802338 @default.
• W2052118204 cites W2012323932 @default.
• W2052118204 cites W2016153121 @default.
• W2052118204 cites W2016623384 @default.
• W2052118204 cites W2017473646 @default.
• W2052118204 cites W2024007859 @default.
• W2052118204 cites W2029809671 @default.
• W2052118204 cites W2033713778 @default.
• W2052118204 cites W2036153387 @default.
• W2052118204 cites W2040179925 @default.
• W2052118204 cites W2041524207 @default.
• W2052118204 cites W2064657913 @default.
• W2052118204 cites W2066161297 @default.
• W2052118204 cites W2082219317 @default.
• W2052118204 cites W2082273415 @default.
• W2052118204 cites W2084211090 @default.
• W2052118204 cites W2085615870 @default.
• W2052118204 cites W2087492003 @default.
• W2052118204 cites W2094032325 @default.
• W2052118204 cites W2095284379 @default.
• W2052118204 cites W2108791332 @default.
• W2052118204 cites W2127583794 @default.
• W2052118204 cites W2138775791 @default.
• W2052118204 cites W2146503628 @default.
• W2052118204 doi "https://doi.org/10.1016/j.ejphar.2009.09.016" @default.
• W2052118204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19765584" @default.
• W2052118204 hasPublicationYear "2009" @default.
• W2052118204 type Work @default.
• W2052118204 sameAs 2052118204 @default.
• W2052118204 citedByCount "34" @default.
• W2052118204 countsByYear W20521182042012 @default.
• W2052118204 countsByYear W20521182042013 @default.
• W2052118204 countsByYear W20521182042014 @default.
• W2052118204 countsByYear W20521182042015 @default.
• W2052118204 countsByYear W20521182042016 @default.
• W2052118204 countsByYear W20521182042017 @default.
• W2052118204 countsByYear W20521182042019 @default.
• W2052118204 countsByYear W20521182042021 @default.
• W2052118204 countsByYear W20521182042022 @default.
• W2052118204 countsByYear W20521182042023 @default.
• W2052118204 crossrefType "journal-article" @default.
• W2052118204 hasAuthorship W2052118204A5012858626 @default.
• W2052118204 hasAuthorship W2052118204A5020670005 @default.
• W2052118204 hasAuthorship W2052118204A5023683621 @default.
• W2052118204 hasAuthorship W2052118204A5025513759 @default.
• W2052118204 hasAuthorship W2052118204A5030908141 @default.
• W2052118204 hasAuthorship W2052118204A5089589231 @default.
• W2052118204 hasConcept C105702510 @default.
• W2052118204 hasConcept C109523444 @default.
• W2052118204 hasConcept C126322002 @default.
• W2052118204 hasConcept C134018914 @default.
• W2052118204 hasConcept C142724271 @default.
• W2052118204 hasConcept C164027704 @default.
• W2052118204 hasConcept C181199279 @default.
• W2052118204 hasConcept C185592680 @default.
• W2052118204 hasConcept C202751555 @default.
• W2052118204 hasConcept C204787440 @default.
• W2052118204 hasConcept C2776151105 @default.
• W2052118204 hasConcept C2776164576 @default.
• W2052118204 hasConcept C2776914184 @default.
• W2052118204 hasConcept C2777652487 @default.
• W2052118204 hasConcept C2777847592 @default.
• W2052118204 hasConcept C2777956040 @default.
• W2052118204 hasConcept C2778004101 @default.
• W2052118204 hasConcept C2780550940 @default.
• W2052118204 hasConcept C2780664492 @default.
• W2052118204 hasConcept C2781403057 @default.
• W2052118204 hasConcept C519581460 @default.
• W2052118204 hasConcept C55493867 @default.
• W2052118204 hasConcept C71924100 @default.
• W2052118204 hasConcept C96942376 @default.
• W2052118204 hasConceptScore W2052118204C105702510 @default.
• W2052118204 hasConceptScore W2052118204C109523444 @default.
• W2052118204 hasConceptScore W2052118204C126322002 @default.
• W2052118204 hasConceptScore W2052118204C134018914 @default.
• W2052118204 hasConceptScore W2052118204C142724271 @default.
• W2052118204 hasConceptScore W2052118204C164027704 @default.
• W2052118204 hasConceptScore W2052118204C181199279 @default.

• next