FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052132146> ?p ?o ?g. }

• W2052132146 endingPage "240" @default.
• W2052132146 startingPage "229" @default.
• W2052132146 abstract "Glyoxal, methylglyoxal and 3-deoxyglucosones are reactive dicarbonyl compounds, which transform free amino groups of proteins and lipoproteins macromolecule into advanced glycation end-products (AGEs). AGEs play a significant role in the pathophysiology of aging and diabetic complications because of their genotoxic effect. Glyoxal also reacts with free amino group of nucleic acids resulting in the formation of DNA–AGEs. The present study reports the genotoxicity and immunogenicity of AGEs formed by Glyoxal–Arginine–Fe3+ (G–Arg–Fe3+) system as a glycating agent. Immunogenicity of native and G–Arg–Fe3+–DNA was probed in female rabbits. Immunofluorescence suggests the presence of immune complex deposition in the kidney section of immunized rabbits. Spectroscopic analysis and melting temperature indicates the structural modification in the human DNA. The modified human DNA is found to be highly immunogenic, whereas unmodified form was simply non-immunogenic. This study shows the presence of auto-antibodies against G–Arg–Fe3+ modified human DNA in the sera of diabetes type 1 and in few cases type 2 patients due to secondary complications of nephropathy. The glyco-oxidative lesions have also been detected in the lymphocyte DNA isolated from patients having type 1 and type 2 diabetes. The results show structural perturbations generating new epitopes in G–Arg–Fe3+–DNA rendering it pretty immunogenic." @default.
• W2052132146 created "2016-06-24" @default.
• W2052132146 creator A5036410879 @default.
• W2052132146 creator A5037323486 @default.
• W2052132146 creator A5038286170 @default.
• W2052132146 creator A5040879382 @default.
• W2052132146 creator A5044502276 @default.
• W2052132146 creator A5045982614 @default.
• W2052132146 creator A5047310723 @default.
• W2052132146 creator A5059161145 @default.
• W2052132146 creator A5073522682 @default.
• W2052132146 date "2014-08-01" @default.
• W2052132146 modified "2023-10-17" @default.
• W2052132146 title "Immunogenicity of DNA-advanced glycation end product fashioned through glyoxal and arginine in the presence of Fe3+: Its potential role in prompt recognition of diabetes mellitus auto-antibodies" @default.
• W2052132146 cites W1497717446 @default.
• W2052132146 cites W1564861591 @default.
• W2052132146 cites W1896619220 @default.
• W2052132146 cites W1964600782 @default.
• W2052132146 cites W1976954519 @default.
• W2052132146 cites W1993143422 @default.
• W2052132146 cites W1993381730 @default.
• W2052132146 cites W2003531367 @default.
• W2052132146 cites W2003817153 @default.
• W2052132146 cites W2004130243 @default.
• W2052132146 cites W2021538179 @default.
• W2052132146 cites W2024251603 @default.
• W2052132146 cites W2027695789 @default.
• W2052132146 cites W2031503758 @default.
• W2052132146 cites W2031533033 @default.
• W2052132146 cites W2035802908 @default.
• W2052132146 cites W2036511281 @default.
• W2052132146 cites W2043493052 @default.
• W2052132146 cites W2049691372 @default.
• W2052132146 cites W2053769775 @default.
• W2052132146 cites W2073714833 @default.
• W2052132146 cites W2084914153 @default.
• W2052132146 cites W2089324920 @default.
• W2052132146 cites W2089652914 @default.
• W2052132146 cites W2090205376 @default.
• W2052132146 cites W2092629964 @default.
• W2052132146 cites W2094341839 @default.
• W2052132146 cites W2101422765 @default.
• W2052132146 cites W2108448809 @default.
• W2052132146 cites W2108762011 @default.
• W2052132146 cites W2112842915 @default.
• W2052132146 cites W2124709546 @default.
• W2052132146 cites W2160234008 @default.
• W2052132146 cites W337536524 @default.
• W2052132146 cites W4233862330 @default.
• W2052132146 doi "https://doi.org/10.1016/j.cbi.2014.06.012" @default.
• W2052132146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24968179" @default.
• W2052132146 hasPublicationYear "2014" @default.
• W2052132146 type Work @default.
• W2052132146 sameAs 2052132146 @default.
• W2052132146 citedByCount "57" @default.
• W2052132146 countsByYear W20521321462014 @default.
• W2052132146 countsByYear W20521321462015 @default.
• W2052132146 countsByYear W20521321462016 @default.
• W2052132146 countsByYear W20521321462017 @default.
• W2052132146 countsByYear W20521321462018 @default.
• W2052132146 countsByYear W20521321462019 @default.
• W2052132146 countsByYear W20521321462020 @default.
• W2052132146 countsByYear W20521321462021 @default.
• W2052132146 countsByYear W20521321462022 @default.
• W2052132146 crossrefType "journal-article" @default.
• W2052132146 hasAuthorship W2052132146A5036410879 @default.
• W2052132146 hasAuthorship W2052132146A5037323486 @default.
• W2052132146 hasAuthorship W2052132146A5038286170 @default.
• W2052132146 hasAuthorship W2052132146A5040879382 @default.
• W2052132146 hasAuthorship W2052132146A5044502276 @default.
• W2052132146 hasAuthorship W2052132146A5045982614 @default.
• W2052132146 hasAuthorship W2052132146A5047310723 @default.
• W2052132146 hasAuthorship W2052132146A5059161145 @default.
• W2052132146 hasAuthorship W2052132146A5073522682 @default.
• W2052132146 hasConcept C147990577 @default.
• W2052132146 hasConcept C153911025 @default.
• W2052132146 hasConcept C159654299 @default.
• W2052132146 hasConcept C170493617 @default.
• W2052132146 hasConcept C178790620 @default.
• W2052132146 hasConcept C181199279 @default.
• W2052132146 hasConcept C185592680 @default.
• W2052132146 hasConcept C203014093 @default.
• W2052132146 hasConcept C2777468819 @default.
• W2052132146 hasConcept C2777603720 @default.
• W2052132146 hasConcept C2778592357 @default.
• W2052132146 hasConcept C2780868878 @default.
• W2052132146 hasConcept C515207424 @default.
• W2052132146 hasConcept C552990157 @default.
• W2052132146 hasConcept C55493867 @default.
• W2052132146 hasConcept C86803240 @default.
• W2052132146 hasConcept C8891405 @default.
• W2052132146 hasConceptScore W2052132146C147990577 @default.
• W2052132146 hasConceptScore W2052132146C153911025 @default.
• W2052132146 hasConceptScore W2052132146C159654299 @default.
• W2052132146 hasConceptScore W2052132146C170493617 @default.
• W2052132146 hasConceptScore W2052132146C178790620 @default.
• W2052132146 hasConceptScore W2052132146C181199279 @default.
• W2052132146 hasConceptScore W2052132146C185592680 @default.

• next