FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052134742> ?p ?o ?g. }

• W2052134742 endingPage "R55" @default.
• W2052134742 startingPage "R55" @default.
• W2052134742 abstract "Mechanical ventilators are increasingly used in critical care units. However, they can cause lung injury, including pulmonary edema. Our previous studies indicated that γ-aminobutyric acid (GABA) receptors are involved in alveolar-fluid homeostasis. The present study investigated the role of GABA receptors in ventilator-induced lung injury.Adult female Sprague-Dawley rats were subjected to high-tidal-volume ventilation of 40 ml/kg body weight for 1 hour, and lung injuries were assessed.High-tidal-volume ventilation resulted in lung injury, as indicated by an increase in total protein in bronchoalveolar fluid, wet-to-dry ratio (indication of pulmonary edema), and Evans Blue dye extravasation (indication of vascular damage). Intratracheal administration of GABA before ventilation significantly reduced the wet-to-dry ratio. Further, histopathologic analysis indicated that GABA reduced ventilator-induced lung injury and apoptosis. GABA-mediated reduction was effectively blocked by the GABAA-receptor antagonist, bicuculline. The GABA-mediated effect was not due to the vascular damage, because no differences in Evans Blue dye extravasation were noted. However, the decrease in alveolar fluid clearance by high-tidal-volume ventilation was partly prevented by GABA, which was blocked by bicuculline.These results suggest that GABA reduces pulmonary edema induced by high-tidal-volume ventilation via its effects on alveolar fluid clearance and apoptosis." @default.
• W2052134742 created "2016-06-24" @default.
• W2052134742 creator A5076045720 @default.
• W2052134742 creator A5076205187 @default.
• W2052134742 date "2012-01-01" @default.
• W2052134742 modified "2023-09-23" @default.
• W2052134742 title "GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance" @default.
• W2052134742 cites W1969086397 @default.
• W2052134742 cites W1970107488 @default.
• W2052134742 cites W1983604849 @default.
• W2052134742 cites W1986296119 @default.
• W2052134742 cites W1989880837 @default.
• W2052134742 cites W1995915139 @default.
• W2052134742 cites W1999277186 @default.
• W2052134742 cites W2003786232 @default.
• W2052134742 cites W2011042737 @default.
• W2052134742 cites W2013551665 @default.
• W2052134742 cites W2013795470 @default.
• W2052134742 cites W2016652838 @default.
• W2052134742 cites W2018641902 @default.
• W2052134742 cites W2019294517 @default.
• W2052134742 cites W2021676882 @default.
• W2052134742 cites W2029031136 @default.
• W2052134742 cites W2033315656 @default.
• W2052134742 cites W2033972819 @default.
• W2052134742 cites W2035043164 @default.
• W2052134742 cites W2039079142 @default.
• W2052134742 cites W2040602786 @default.
• W2052134742 cites W2046044139 @default.
• W2052134742 cites W2052771537 @default.
• W2052134742 cites W2075411448 @default.
• W2052134742 cites W2081621550 @default.
• W2052134742 cites W2082005220 @default.
• W2052134742 cites W2096083834 @default.
• W2052134742 cites W2098129921 @default.
• W2052134742 cites W2100789462 @default.
• W2052134742 cites W2102329408 @default.
• W2052134742 cites W2103014899 @default.
• W2052134742 cites W2109704422 @default.
• W2052134742 cites W2133654255 @default.
• W2052134742 cites W2134766199 @default.
• W2052134742 cites W2137471600 @default.
• W2052134742 cites W2137507678 @default.
• W2052134742 cites W2138302361 @default.
• W2052134742 cites W2141818933 @default.
• W2052134742 cites W2148535962 @default.
• W2052134742 cites W2153331362 @default.
• W2052134742 cites W2156876013 @default.
• W2052134742 cites W2172201608 @default.
• W2052134742 cites W3089778019 @default.
• W2052134742 doi "https://doi.org/10.1186/cc11298" @default.
• W2052134742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3681384" @default.
• W2052134742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22480160" @default.
• W2052134742 hasPublicationYear "2012" @default.
• W2052134742 type Work @default.
• W2052134742 sameAs 2052134742 @default.
• W2052134742 citedByCount "24" @default.
• W2052134742 countsByYear W20521347422012 @default.
• W2052134742 countsByYear W20521347422013 @default.
• W2052134742 countsByYear W20521347422014 @default.
• W2052134742 countsByYear W20521347422015 @default.
• W2052134742 countsByYear W20521347422017 @default.
• W2052134742 countsByYear W20521347422019 @default.
• W2052134742 countsByYear W20521347422020 @default.
• W2052134742 countsByYear W20521347422021 @default.
• W2052134742 countsByYear W20521347422022 @default.
• W2052134742 countsByYear W20521347422023 @default.
• W2052134742 crossrefType "journal-article" @default.
• W2052134742 hasAuthorship W2052134742A5076045720 @default.
• W2052134742 hasAuthorship W2052134742A5076205187 @default.
• W2052134742 hasBestOaLocation W20521347421 @default.
• W2052134742 hasConcept C126322002 @default.
• W2052134742 hasConcept C127413603 @default.
• W2052134742 hasConcept C142724271 @default.
• W2052134742 hasConcept C168258287 @default.
• W2052134742 hasConcept C170493617 @default.
• W2052134742 hasConcept C200457457 @default.
• W2052134742 hasConcept C2776468924 @default.
• W2052134742 hasConcept C2777080012 @default.
• W2052134742 hasConcept C2777257755 @default.
• W2052134742 hasConcept C2777649898 @default.
• W2052134742 hasConcept C2777714996 @default.
• W2052134742 hasConcept C2777961210 @default.
• W2052134742 hasConcept C2779540182 @default.
• W2052134742 hasConcept C2780763569 @default.
• W2052134742 hasConcept C2780886150 @default.
• W2052134742 hasConcept C42219234 @default.
• W2052134742 hasConcept C534529494 @default.
• W2052134742 hasConcept C71924100 @default.
• W2052134742 hasConcept C78519656 @default.
• W2052134742 hasConceptScore W2052134742C126322002 @default.
• W2052134742 hasConceptScore W2052134742C127413603 @default.
• W2052134742 hasConceptScore W2052134742C142724271 @default.
• W2052134742 hasConceptScore W2052134742C168258287 @default.
• W2052134742 hasConceptScore W2052134742C170493617 @default.
• W2052134742 hasConceptScore W2052134742C200457457 @default.
• W2052134742 hasConceptScore W2052134742C2776468924 @default.
• W2052134742 hasConceptScore W2052134742C2777080012 @default.

• next