Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052148270> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2052148270 endingPage "260" @default.
- W2052148270 startingPage "254" @default.
- W2052148270 abstract "We have shown that intrathymic (IT) injection of alloantigen with antirat lymphocyte serum (ALS) treatment can induce donor-specific allograft acceptance. The purpose of this study was to investigate whether T-regulatory (T-reg) cells play a role in the maintenance of donor-specific heart graft tolerance that develops after IT injection of Lewis (LEW, RT1(l)) alloantigen into a Dark Agouti (DA, RT1(a)).Naïve DA rats were injected IT with 2.5 x10(7) LEW donor splenocytes and injected intraperitoneally with 1 mL ALS. Twenty-one days after pretreatment, a LEW or Brown Norway (BN, RT1(n)) heart was transplanted into a treated DA recipient. Splenocytes (1 x 10(8) or 5 x 10(7)) from a LEW heart-tolerant long-term survivor (LTS; >60 days) DA recipient were harvested and adoptively transferred (AT) into an irradiated (450 rad) naïve DA rat 24 hours before transplanting a LEW heart.All LEW heart allografts were rejected by untreated DA rats in a mean survival time (MST) of 7.4 +/- 1.7 days (n=7). In contrast, 66.7% of LEW heart grafts into IT+ALS-pretreated DA recipients were accepted indefinitely (n=24). When either 1 x 10(8) (n=5) or 5 x 10(7) (n=5) splenocytes from a LEW heart graft-tolerant LTS (>60 days) DA recipient were AT into a new naïve DA rat, all new LEW heart grafts were accepted indefinitely.The donor-specific tolerance that develops after IT+ALS-induced LEW heart acceptance by DA recipients can be transferred adoptively to new naïve DA recipients, thus indicating that it is infectious tolerance." @default.
- W2052148270 created "2016-06-24" @default.
- W2052148270 creator A5001543955 @default.
- W2052148270 creator A5037541501 @default.
- W2052148270 creator A5043459798 @default.
- W2052148270 creator A5052845814 @default.
- W2052148270 creator A5079206367 @default.
- W2052148270 date "2005-08-01" @default.
- W2052148270 modified "2023-10-14" @default.
- W2052148270 title "Infectious tolerance develops after intrathymic alloantigen–induced acceptance of rat heart allografts can be adoptively transferred" @default.
- W2052148270 cites W1553215445 @default.
- W2052148270 cites W1973474616 @default.
- W2052148270 cites W1985521658 @default.
- W2052148270 cites W1998888991 @default.
- W2052148270 cites W2001612209 @default.
- W2052148270 cites W2015034698 @default.
- W2052148270 cites W2039175257 @default.
- W2052148270 cites W2040024029 @default.
- W2052148270 cites W2042689607 @default.
- W2052148270 cites W2054271415 @default.
- W2052148270 cites W2067996571 @default.
- W2052148270 cites W2068238618 @default.
- W2052148270 cites W2073113705 @default.
- W2052148270 cites W2079376270 @default.
- W2052148270 cites W2085366465 @default.
- W2052148270 cites W2088400327 @default.
- W2052148270 cites W2102106323 @default.
- W2052148270 cites W2112723696 @default.
- W2052148270 cites W2123375678 @default.
- W2052148270 cites W2134615727 @default.
- W2052148270 cites W2136377200 @default.
- W2052148270 cites W2148561721 @default.
- W2052148270 cites W2157712507 @default.
- W2052148270 doi "https://doi.org/10.1016/j.surg.2005.06.012" @default.
- W2052148270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153434" @default.
- W2052148270 hasPublicationYear "2005" @default.
- W2052148270 type Work @default.
- W2052148270 sameAs 2052148270 @default.
- W2052148270 citedByCount "7" @default.
- W2052148270 countsByYear W20521482702013 @default.
- W2052148270 crossrefType "journal-article" @default.
- W2052148270 hasAuthorship W2052148270A5001543955 @default.
- W2052148270 hasAuthorship W2052148270A5037541501 @default.
- W2052148270 hasAuthorship W2052148270A5043459798 @default.
- W2052148270 hasAuthorship W2052148270A5052845814 @default.
- W2052148270 hasAuthorship W2052148270A5079206367 @default.
- W2052148270 hasConcept C126322002 @default.
- W2052148270 hasConcept C16685009 @default.
- W2052148270 hasConcept C189976730 @default.
- W2052148270 hasConcept C203014093 @default.
- W2052148270 hasConcept C2777702733 @default.
- W2052148270 hasConcept C2778849806 @default.
- W2052148270 hasConcept C2910855829 @default.
- W2052148270 hasConcept C2911091166 @default.
- W2052148270 hasConcept C71924100 @default.
- W2052148270 hasConcept C8891405 @default.
- W2052148270 hasConceptScore W2052148270C126322002 @default.
- W2052148270 hasConceptScore W2052148270C16685009 @default.
- W2052148270 hasConceptScore W2052148270C189976730 @default.
- W2052148270 hasConceptScore W2052148270C203014093 @default.
- W2052148270 hasConceptScore W2052148270C2777702733 @default.
- W2052148270 hasConceptScore W2052148270C2778849806 @default.
- W2052148270 hasConceptScore W2052148270C2910855829 @default.
- W2052148270 hasConceptScore W2052148270C2911091166 @default.
- W2052148270 hasConceptScore W2052148270C71924100 @default.
- W2052148270 hasConceptScore W2052148270C8891405 @default.
- W2052148270 hasIssue "2" @default.
- W2052148270 hasLocation W20521482701 @default.
- W2052148270 hasLocation W20521482702 @default.
- W2052148270 hasOpenAccess W2052148270 @default.
- W2052148270 hasPrimaryLocation W20521482701 @default.
- W2052148270 hasRelatedWork W2029707895 @default.
- W2052148270 hasRelatedWork W2052148270 @default.
- W2052148270 hasRelatedWork W2070925663 @default.
- W2052148270 hasRelatedWork W2141831122 @default.
- W2052148270 hasRelatedWork W2349689481 @default.
- W2052148270 hasRelatedWork W2380382072 @default.
- W2052148270 hasRelatedWork W2404113922 @default.
- W2052148270 hasRelatedWork W2437832493 @default.
- W2052148270 hasRelatedWork W2470018438 @default.
- W2052148270 hasRelatedWork W2576837937 @default.
- W2052148270 hasVolume "138" @default.
- W2052148270 isParatext "false" @default.
- W2052148270 isRetracted "false" @default.
- W2052148270 magId "2052148270" @default.
- W2052148270 workType "article" @default.