FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052152665> ?p ?o ?g. }

• W2052152665 endingPage "3748" @default.
• W2052152665 startingPage "3740" @default.
• W2052152665 abstract "In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)-specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation.Site-directed mutagenesis and crystallographic studies were performed to reveal crucial contact points between the CII antibody and the triple-helical CII peptide.The crystal structure of a pathogenic autoantibody bound to a major triple-helical epitope present on CII was determined, allowing a first and detailed description of the interactions within an arthritogenic complex that is frequently occurring in both mice and humans with autoimmune arthritis. The crystal structure emphasizes the role of arginine residues located in a commonly recognized motif on CII and reveals that germline-encoded elements are involved in the interaction with the epitope.The crystal structure of an arthritogenic antibody binding a triple-helical epitope on CII indicates a crucial role of germline-encoded and arginine residues as the target structures." @default.
• W2052152665 created "2016-06-24" @default.
• W2052152665 creator A5010549483 @default.
• W2052152665 creator A5010629312 @default.
• W2052152665 creator A5032343417 @default.
• W2052152665 creator A5038259876 @default.
• W2052152665 creator A5044356845 @default.
• W2052152665 creator A5049058428 @default.
• W2052152665 creator A5074114114 @default.
• W2052152665 date "2011-11-29" @default.
• W2052152665 modified "2023-09-27" @default.
• W2052152665 title "Crystal structure of an arthritogenic anticollagen immune complex" @default.
• W2052152665 cites W1873874031 @default.
• W2052152665 cites W1963791857 @default.
• W2052152665 cites W1965696287 @default.
• W2052152665 cites W1974913693 @default.
• W2052152665 cites W1974942850 @default.
• W2052152665 cites W1979221090 @default.
• W2052152665 cites W1989515097 @default.
• W2052152665 cites W1989552401 @default.
• W2052152665 cites W1996058344 @default.
• W2052152665 cites W2001966503 @default.
• W2052152665 cites W2003111769 @default.
• W2052152665 cites W2004141812 @default.
• W2052152665 cites W2004633983 @default.
• W2052152665 cites W2010127700 @default.
• W2052152665 cites W2013437439 @default.
• W2052152665 cites W2024988150 @default.
• W2052152665 cites W2032247503 @default.
• W2052152665 cites W2034012983 @default.
• W2052152665 cites W2035503835 @default.
• W2052152665 cites W2038840577 @default.
• W2052152665 cites W2044532924 @default.
• W2052152665 cites W2047032886 @default.
• W2052152665 cites W2047473852 @default.
• W2052152665 cites W2054802348 @default.
• W2052152665 cites W2054851985 @default.
• W2052152665 cites W2061766263 @default.
• W2052152665 cites W2063944766 @default.
• W2052152665 cites W2067105956 @default.
• W2052152665 cites W2067416672 @default.
• W2052152665 cites W2085040142 @default.
• W2052152665 cites W2093810280 @default.
• W2052152665 cites W2094801824 @default.
• W2052152665 cites W2101290319 @default.
• W2052152665 cites W2109992876 @default.
• W2052152665 cites W2110500677 @default.
• W2052152665 cites W2120689672 @default.
• W2052152665 cites W2124026197 @default.
• W2052152665 cites W2128065231 @default.
• W2052152665 cites W2163341755 @default.
• W2052152665 doi "https://doi.org/10.1002/art.30611" @default.
• W2052152665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22127694" @default.
• W2052152665 hasPublicationYear "2011" @default.
• W2052152665 type Work @default.
• W2052152665 sameAs 2052152665 @default.
• W2052152665 citedByCount "26" @default.
• W2052152665 countsByYear W20521526652012 @default.
• W2052152665 countsByYear W20521526652013 @default.
• W2052152665 countsByYear W20521526652014 @default.
• W2052152665 countsByYear W20521526652015 @default.
• W2052152665 countsByYear W20521526652016 @default.
• W2052152665 countsByYear W20521526652017 @default.
• W2052152665 countsByYear W20521526652018 @default.
• W2052152665 countsByYear W20521526652019 @default.
• W2052152665 countsByYear W20521526652020 @default.
• W2052152665 countsByYear W20521526652022 @default.
• W2052152665 countsByYear W20521526652023 @default.
• W2052152665 crossrefType "journal-article" @default.
• W2052152665 hasAuthorship W2052152665A5010549483 @default.
• W2052152665 hasAuthorship W2052152665A5010629312 @default.
• W2052152665 hasAuthorship W2052152665A5032343417 @default.
• W2052152665 hasAuthorship W2052152665A5038259876 @default.
• W2052152665 hasAuthorship W2052152665A5044356845 @default.
• W2052152665 hasAuthorship W2052152665A5049058428 @default.
• W2052152665 hasAuthorship W2052152665A5074114114 @default.
• W2052152665 hasConcept C159654299 @default.
• W2052152665 hasConcept C163764329 @default.
• W2052152665 hasConcept C185592680 @default.
• W2052152665 hasConcept C195616568 @default.
• W2052152665 hasConcept C203014093 @default.
• W2052152665 hasConcept C2777077863 @default.
• W2052152665 hasConcept C2780130043 @default.
• W2052152665 hasConcept C2781013607 @default.
• W2052152665 hasConcept C86803240 @default.
• W2052152665 hasConceptScore W2052152665C159654299 @default.
• W2052152665 hasConceptScore W2052152665C163764329 @default.
• W2052152665 hasConceptScore W2052152665C185592680 @default.
• W2052152665 hasConceptScore W2052152665C195616568 @default.
• W2052152665 hasConceptScore W2052152665C203014093 @default.
• W2052152665 hasConceptScore W2052152665C2777077863 @default.
• W2052152665 hasConceptScore W2052152665C2780130043 @default.
• W2052152665 hasConceptScore W2052152665C2781013607 @default.
• W2052152665 hasConceptScore W2052152665C86803240 @default.
• W2052152665 hasIssue "12" @default.
• W2052152665 hasLocation W20521526651 @default.
• W2052152665 hasLocation W20521526652 @default.
• W2052152665 hasOpenAccess W2052152665 @default.

• next