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• W2052155647 abstract "T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low-affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold." @default.
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• W2052155647 date "2005-06-01" @default.
• W2052155647 modified "2023-10-03" @default.
• W2052155647 title "Rationale for T Cell Inhibition by Cyclosporin A in Major Autoimmune Diseases" @default.
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• W2052155647 doi "https://doi.org/10.1196/annals.1361.110" @default.
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