Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052156860> ?p ?o ?g. }
- W2052156860 endingPage "487" @default.
- W2052156860 startingPage "482" @default.
- W2052156860 abstract "Some of the most prevalent human degenerative diseases appear as a result of the misfolding and aggregation of proteins. Compelling evidence suggest that misfolded protein aggregates play an important role in cell dysfunction and tissue damage, leading to the disease. Prion protein (Prion diseases), amyloid-beta (Alzheimer's disease), alpha-synuclein (Parkinson's disease), Huntingtin (Huntington's disease), serum amyloid A (AA amyloidosis) and islet amyloid polypeptide (type 2 diabetes) are some of the proteins that trigger disease when they get misfolded. The recent understanding of the crucial role of misfolded proteins as well as the structural requirements and mechanism of protein misfolding have raised the possibility that these diseases may be transmissible by self-propagation of the protein misfolding process in a similar way as the infamous prions transmit prion diseases. Future research in this field should aim to clarify this possibility and translate the knowledge of the basic disease mechanisms into development of novel strategies for early diagnosis and efficient treatment." @default.
- W2052156860 created "2016-06-24" @default.
- W2052156860 creator A5014963985 @default.
- W2052156860 creator A5085647135 @default.
- W2052156860 date "2011-07-01" @default.
- W2052156860 modified "2023-10-01" @default.
- W2052156860 title "Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission" @default.
- W2052156860 cites W1493986974 @default.
- W2052156860 cites W1972025839 @default.
- W2052156860 cites W1980115442 @default.
- W2052156860 cites W1981288814 @default.
- W2052156860 cites W1981458288 @default.
- W2052156860 cites W1984131083 @default.
- W2052156860 cites W1988146888 @default.
- W2052156860 cites W1989208474 @default.
- W2052156860 cites W1990149510 @default.
- W2052156860 cites W1991241547 @default.
- W2052156860 cites W1995400471 @default.
- W2052156860 cites W2004185979 @default.
- W2052156860 cites W2004968757 @default.
- W2052156860 cites W2006103103 @default.
- W2052156860 cites W2007157911 @default.
- W2052156860 cites W2016229814 @default.
- W2052156860 cites W2016351953 @default.
- W2052156860 cites W2016777985 @default.
- W2052156860 cites W2016960360 @default.
- W2052156860 cites W2017126556 @default.
- W2052156860 cites W2019931686 @default.
- W2052156860 cites W2021776289 @default.
- W2052156860 cites W2022680168 @default.
- W2052156860 cites W2022819036 @default.
- W2052156860 cites W2023601625 @default.
- W2052156860 cites W2030725090 @default.
- W2052156860 cites W2034181033 @default.
- W2052156860 cites W2035282151 @default.
- W2052156860 cites W2037322147 @default.
- W2052156860 cites W2037558767 @default.
- W2052156860 cites W2042978244 @default.
- W2052156860 cites W2044407202 @default.
- W2052156860 cites W2044448989 @default.
- W2052156860 cites W2050647292 @default.
- W2052156860 cites W2059804089 @default.
- W2052156860 cites W2061005919 @default.
- W2052156860 cites W2063013822 @default.
- W2052156860 cites W2067682626 @default.
- W2052156860 cites W2068495410 @default.
- W2052156860 cites W2069776708 @default.
- W2052156860 cites W2073420453 @default.
- W2052156860 cites W2073516240 @default.
- W2052156860 cites W2075548770 @default.
- W2052156860 cites W2077118428 @default.
- W2052156860 cites W2077120971 @default.
- W2052156860 cites W2082670534 @default.
- W2052156860 cites W2082890051 @default.
- W2052156860 cites W2084469782 @default.
- W2052156860 cites W2084670683 @default.
- W2052156860 cites W2085703547 @default.
- W2052156860 cites W2089215677 @default.
- W2052156860 cites W2089767543 @default.
- W2052156860 cites W2090175640 @default.
- W2052156860 cites W2090797167 @default.
- W2052156860 cites W2093261175 @default.
- W2052156860 cites W2096601751 @default.
- W2052156860 cites W2097965815 @default.
- W2052156860 cites W2098022922 @default.
- W2052156860 cites W2099340107 @default.
- W2052156860 cites W2099370040 @default.
- W2052156860 cites W2100785397 @default.
- W2052156860 cites W2103270514 @default.
- W2052156860 cites W2103717170 @default.
- W2052156860 cites W2104757352 @default.
- W2052156860 cites W2104849621 @default.
- W2052156860 cites W2107037134 @default.
- W2052156860 cites W2108060249 @default.
- W2052156860 cites W2109727228 @default.
- W2052156860 cites W2110516310 @default.
- W2052156860 cites W2119141718 @default.
- W2052156860 cites W2128048423 @default.
- W2052156860 cites W2129412868 @default.
- W2052156860 cites W2139785451 @default.
- W2052156860 cites W2145904082 @default.
- W2052156860 cites W2147461093 @default.
- W2052156860 cites W2149761960 @default.
- W2052156860 cites W2154109443 @default.
- W2052156860 cites W2156215695 @default.
- W2052156860 cites W2156281143 @default.
- W2052156860 cites W2163210644 @default.
- W2052156860 cites W2164332388 @default.
- W2052156860 cites W2171495114 @default.
- W2052156860 cites W2410485030 @default.
- W2052156860 cites W4296154147 @default.
- W2052156860 doi "https://doi.org/10.1016/j.semcdb.2011.04.002" @default.
- W2052156860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3175247" @default.
- W2052156860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21571086" @default.
- W2052156860 hasPublicationYear "2011" @default.
- W2052156860 type Work @default.
- W2052156860 sameAs 2052156860 @default.
- W2052156860 citedByCount "166" @default.