FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052156902> ?p ?o ?g. }

• W2052156902 endingPage "271" @default.
• W2052156902 startingPage "264" @default.
• W2052156902 abstract "Aldosterone itself has been reported to participate in mediating renal injury, and it was confirmed that the aldosterone synthase CYP11B2 gene, protein, and aldosterone production are locally present in the kidney. To test the hypothesis that a mineralocorticoid receptor antagonist might ameliorate diabetic nephropathy and the inhibition of renal CYP11B2 expression might be associated with these renoprotective effects, spironolactone (50 mg/kg/day) was administered by gavage to uninephrectomized diabetic rats for 3 weeks. Streptozotocin (55 mg/kg, i.v.) significantly increased urinary protein excretion and collagen deposition in glomerular and tubulointerstitial areas in the kidney, which were attenuated by spironolactone treatment. RT-PCR and Western blot analysis revealed that the expression of mRNA for collagen I/IV, transforming growth factor-beta, NADPH oxidase and mineralocorticoid receptor and the mineralocorticoid receptor protein in the kidney was enhanced in the uninephrectomized diabetic rat kidney and that the overexpression of these molecules was suppressed by spironolactone. Renal angiotensin converting enzyme was activated and overexpressed in diabetic rats, and spironolactone inhibited these changes. We demonstrated that spironolactone prevented the streptozotocin-induced increase in the renal CYP11B2 mRNA content. Controlling blood glucose level with insulin also attenuated the renal expression of mRNA for CYP11B2. On the other hand, the treatment of spironolactone in the present study did not affect blood glucose level or blood pressure in uninephrectomized streptozotocin-induced diabetic rats. These results suggest that spironolactone exerted renoprotective effects in uninephrectomized streptozotocin-induced diabetic rats and inhibited local renin-angiotensin-aldosterone system, such as the ACE expression and the hyperglycemia-induced overexpression of CYP11B2, in the kidney." @default.
• W2052156902 created "2016-06-24" @default.
• W2052156902 creator A5004104413 @default.
• W2052156902 creator A5019741450 @default.
• W2052156902 creator A5029590219 @default.
• W2052156902 creator A5039089565 @default.
• W2052156902 creator A5043258384 @default.
• W2052156902 creator A5066259851 @default.
• W2052156902 creator A5085004855 @default.
• W2052156902 creator A5089401023 @default.
• W2052156902 date "2008-07-01" @default.
• W2052156902 modified "2023-09-29" @default.
• W2052156902 title "Spironolactone exhibits direct renoprotective effects and inhibits renal renin–angiotensin–aldosterone system in diabetic rats" @default.
• W2052156902 cites W1964527653 @default.
• W2052156902 cites W1997281940 @default.
• W2052156902 cites W2012258975 @default.
• W2052156902 cites W2017576713 @default.
• W2052156902 cites W2020877653 @default.
• W2052156902 cites W2027822776 @default.
• W2052156902 cites W2031925589 @default.
• W2052156902 cites W2040961193 @default.
• W2052156902 cites W2044773944 @default.
• W2052156902 cites W2056976690 @default.
• W2052156902 cites W2067898305 @default.
• W2052156902 cites W2076117260 @default.
• W2052156902 cites W2085992967 @default.
• W2052156902 cites W2111945961 @default.
• W2052156902 cites W2113472065 @default.
• W2052156902 cites W2116163401 @default.
• W2052156902 cites W2122242241 @default.
• W2052156902 cites W2132389690 @default.
• W2052156902 cites W2144673000 @default.
• W2052156902 cites W2148155169 @default.
• W2052156902 cites W2156718697 @default.
• W2052156902 cites W2159020799 @default.
• W2052156902 cites W2161727113 @default.
• W2052156902 cites W2163709605 @default.
• W2052156902 cites W2164551443 @default.
• W2052156902 cites W2316067769 @default.
• W2052156902 cites W2323458614 @default.
• W2052156902 cites W2615684303 @default.
• W2052156902 cites W26905628 @default.
• W2052156902 cites W2921356930 @default.
• W2052156902 cites W3021250193 @default.
• W2052156902 cites W4230677304 @default.
• W2052156902 cites W4241079194 @default.
• W2052156902 cites W4255454238 @default.
• W2052156902 doi "https://doi.org/10.1016/j.ejphar.2008.06.019" @default.
• W2052156902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18582458" @default.
• W2052156902 hasPublicationYear "2008" @default.
• W2052156902 type Work @default.
• W2052156902 sameAs 2052156902 @default.
• W2052156902 citedByCount "76" @default.
• W2052156902 countsByYear W20521569022012 @default.
• W2052156902 countsByYear W20521569022013 @default.
• W2052156902 countsByYear W20521569022014 @default.
• W2052156902 countsByYear W20521569022015 @default.
• W2052156902 countsByYear W20521569022016 @default.
• W2052156902 countsByYear W20521569022017 @default.
• W2052156902 countsByYear W20521569022018 @default.
• W2052156902 countsByYear W20521569022019 @default.
• W2052156902 countsByYear W20521569022020 @default.
• W2052156902 countsByYear W20521569022021 @default.
• W2052156902 countsByYear W20521569022022 @default.
• W2052156902 countsByYear W20521569022023 @default.
• W2052156902 crossrefType "journal-article" @default.
• W2052156902 hasAuthorship W2052156902A5004104413 @default.
• W2052156902 hasAuthorship W2052156902A5019741450 @default.
• W2052156902 hasAuthorship W2052156902A5029590219 @default.
• W2052156902 hasAuthorship W2052156902A5039089565 @default.
• W2052156902 hasAuthorship W2052156902A5043258384 @default.
• W2052156902 hasAuthorship W2052156902A5066259851 @default.
• W2052156902 hasAuthorship W2052156902A5085004855 @default.
• W2052156902 hasAuthorship W2052156902A5089401023 @default.
• W2052156902 hasConcept C126322002 @default.
• W2052156902 hasConcept C134018914 @default.
• W2052156902 hasConcept C185592680 @default.
• W2052156902 hasConcept C189135053 @default.
• W2052156902 hasConcept C198710026 @default.
• W2052156902 hasConcept C2776069600 @default.
• W2052156902 hasConcept C2776379505 @default.
• W2052156902 hasConcept C2778525890 @default.
• W2052156902 hasConcept C2779280383 @default.
• W2052156902 hasConcept C2779922275 @default.
• W2052156902 hasConcept C2780091579 @default.
• W2052156902 hasConcept C2780249997 @default.
• W2052156902 hasConcept C555293320 @default.
• W2052156902 hasConcept C71924100 @default.
• W2052156902 hasConcept C84393581 @default.
• W2052156902 hasConceptScore W2052156902C126322002 @default.
• W2052156902 hasConceptScore W2052156902C134018914 @default.
• W2052156902 hasConceptScore W2052156902C185592680 @default.
• W2052156902 hasConceptScore W2052156902C189135053 @default.
• W2052156902 hasConceptScore W2052156902C198710026 @default.
• W2052156902 hasConceptScore W2052156902C2776069600 @default.
• W2052156902 hasConceptScore W2052156902C2776379505 @default.
• W2052156902 hasConceptScore W2052156902C2778525890 @default.
• W2052156902 hasConceptScore W2052156902C2779280383 @default.

• next