FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052167002> ?p ?o ?g. }

• W2052167002 endingPage "1751" @default.
• W2052167002 startingPage "1742" @default.
• W2052167002 abstract "The studies reported here were undertaken to define the regulation and functional importance of zinc-dependent histone deacetylase (Zn-HDAC) activity during liver regeneration using the mouse partial hepatectomy (PH) model. The results showed that hepatic HDAC activity was significantly increased in nuclear and cytoplasmic fractions following PH. Further analyses showed isoform-specific effects of PH on HDAC messenger RNA (mRNA) and protein expression, with increased expression of the class I HDACs, 1 and 8, and class II HDAC4 in regenerating liver. Hepatic expression of (class II) HDAC5 was unchanged after PH; however, HDAC5 exhibited transient nuclear accumulation in regenerating liver. These changes in hepatic HDAC expression, subcellular localization, and activity coincided with diminished histone acetylation in regenerating liver. The significance of these events was investigated by determining the effects of suberoylanilide hydroxyamic acid (SAHA, a specific inhibitor of Zn-HDAC activity) on hepatic regeneration. The results showed that SAHA treatment suppressed the effects of PH on histone deacetylation and hepatocellular bromodeoxyuridine (BrdU) incorporation. Further examination showed that SAHA blunted hepatic expression and activation of cell cycle signals downstream of induction of cyclin D1 expression in mice subjected to PH.The data reported here demonstrate isoform-specific regulation of Zn-HDAC expression, subcellular localization, and activity in regenerating liver. These studies also indicate that HDAC activity promotes liver regeneration by regulating hepatocellular cell cycle progression at a step downstream of cyclin D1 induction." @default.
• W2052167002 created "2016-06-24" @default.
• W2052167002 creator A5036761673 @default.
• W2052167002 creator A5066009012 @default.
• W2052167002 creator A5079090096 @default.
• W2052167002 date "2013-04-23" @default.
• W2052167002 modified "2023-10-14" @default.
• W2052167002 title "Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration" @default.
• W2052167002 cites W1576011410 @default.
• W2052167002 cites W1605869385 @default.
• W2052167002 cites W1965448600 @default.
• W2052167002 cites W1965874843 @default.
• W2052167002 cites W1975307961 @default.
• W2052167002 cites W1975692560 @default.
• W2052167002 cites W1978375723 @default.
• W2052167002 cites W1985279458 @default.
• W2052167002 cites W1988049858 @default.
• W2052167002 cites W1990750894 @default.
• W2052167002 cites W1991420853 @default.
• W2052167002 cites W2000595541 @default.
• W2052167002 cites W2001302166 @default.
• W2052167002 cites W2013853905 @default.
• W2052167002 cites W2014350573 @default.
• W2052167002 cites W2014885180 @default.
• W2052167002 cites W2027202237 @default.
• W2052167002 cites W2031954417 @default.
• W2052167002 cites W2044919636 @default.
• W2052167002 cites W2050331458 @default.
• W2052167002 cites W2050931169 @default.
• W2052167002 cites W2062238480 @default.
• W2052167002 cites W2068691871 @default.
• W2052167002 cites W2073978750 @default.
• W2052167002 cites W2087714970 @default.
• W2052167002 cites W2087821811 @default.
• W2052167002 cites W2088150017 @default.
• W2052167002 cites W2089399727 @default.
• W2052167002 cites W2115552194 @default.
• W2052167002 cites W2136497480 @default.
• W2052167002 cites W2144575277 @default.
• W2052167002 cites W2164453551 @default.
• W2052167002 cites W2165439041 @default.
• W2052167002 cites W2168680690 @default.
• W2052167002 cites W4210995852 @default.
• W2052167002 cites W4237329722 @default.
• W2052167002 cites W89320799 @default.
• W2052167002 doi "https://doi.org/10.1002/hep.26206" @default.
• W2052167002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3825707" @default.
• W2052167002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23258575" @default.
• W2052167002 hasPublicationYear "2013" @default.
• W2052167002 type Work @default.
• W2052167002 sameAs 2052167002 @default.
• W2052167002 citedByCount "31" @default.
• W2052167002 countsByYear W20521670022014 @default.
• W2052167002 countsByYear W20521670022015 @default.
• W2052167002 countsByYear W20521670022016 @default.
• W2052167002 countsByYear W20521670022017 @default.
• W2052167002 countsByYear W20521670022018 @default.
• W2052167002 countsByYear W20521670022019 @default.
• W2052167002 countsByYear W20521670022020 @default.
• W2052167002 countsByYear W20521670022021 @default.
• W2052167002 countsByYear W20521670022022 @default.
• W2052167002 countsByYear W20521670022023 @default.
• W2052167002 crossrefType "journal-article" @default.
• W2052167002 hasAuthorship W2052167002A5036761673 @default.
• W2052167002 hasAuthorship W2052167002A5066009012 @default.
• W2052167002 hasAuthorship W2052167002A5079090096 @default.
• W2052167002 hasBestOaLocation W20521670021 @default.
• W2052167002 hasConcept C104317684 @default.
• W2052167002 hasConcept C119157956 @default.
• W2052167002 hasConcept C1491633281 @default.
• W2052167002 hasConcept C153911025 @default.
• W2052167002 hasConcept C171056886 @default.
• W2052167002 hasConcept C190062978 @default.
• W2052167002 hasConcept C199835354 @default.
• W2052167002 hasConcept C27253355 @default.
• W2052167002 hasConcept C2776795407 @default.
• W2052167002 hasConcept C2776879804 @default.
• W2052167002 hasConcept C2778305200 @default.
• W2052167002 hasConcept C29537977 @default.
• W2052167002 hasConcept C4951695 @default.
• W2052167002 hasConcept C55493867 @default.
• W2052167002 hasConcept C58793620 @default.
• W2052167002 hasConcept C64927066 @default.
• W2052167002 hasConcept C71723506 @default.
• W2052167002 hasConcept C85240754 @default.
• W2052167002 hasConcept C86803240 @default.
• W2052167002 hasConcept C95444343 @default.
• W2052167002 hasConceptScore W2052167002C104317684 @default.
• W2052167002 hasConceptScore W2052167002C119157956 @default.
• W2052167002 hasConceptScore W2052167002C1491633281 @default.
• W2052167002 hasConceptScore W2052167002C153911025 @default.
• W2052167002 hasConceptScore W2052167002C171056886 @default.
• W2052167002 hasConceptScore W2052167002C190062978 @default.
• W2052167002 hasConceptScore W2052167002C199835354 @default.
• W2052167002 hasConceptScore W2052167002C27253355 @default.
• W2052167002 hasConceptScore W2052167002C2776795407 @default.
• W2052167002 hasConceptScore W2052167002C2776879804 @default.
• W2052167002 hasConceptScore W2052167002C2778305200 @default.

• next