FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052193731> ?p ?o ?g. }

• W2052193731 endingPage "715" @default.
• W2052193731 startingPage "701" @default.
• W2052193731 abstract "Following chemical mutagenesis and multiple-step indirect selection, four clones of Chinese hamster V79 cells were isolated which exhibited auxotrophy for thymidine, deoxycytidine, or deoxyuridine but not for cytidine or uridine. All were resistant to uridine, 3-deazauridine, 5-fluorouridine, thymidine, and cytosine arabinoside at concentrations that were toxic to wild-type V79 cells. The cytidine 5′-triphosphate (CTP) and deoxycytidine 5′-triphosphate (dCTP) pools in the mutants were expanded, but the uridine 5′-triphosphate (UTP) pool either decreased or remained unchanged relative to the wild-type level. Furthermore, since the parental cells appear to be deficient in dCMP deaminase activity and CTP (or one of its metabolites) has been shown to inhibit uridine 5′-diphosphate (UDP) reduction, an elevated CTP level should lead to the observed thymidine auxotrophy. It also explains the joint resistance of mutant clones to thymidine and cytosine arabinoside. The change in the ratio of intracellular dCTP to thymidine 5′-triphosphate (dTTP) may be responsible for the elevation in the rates of spontaneous mutations in these mutants." @default.
• W2052193731 created "2016-06-24" @default.
• W2052193731 creator A5021216992 @default.
• W2052193731 creator A5025704724 @default.
• W2052193731 creator A5049296315 @default.
• W2052193731 creator A5059665300 @default.
• W2052193731 date "1984-08-01" @default.
• W2052193731 modified "2023-10-16" @default.
• W2052193731 title "Pleiotropic mutants of Chinese hamster cells with altered cytidine 5?-triphosphate synthetase" @default.
• W2052193731 cites W1543427241 @default.
• W2052193731 cites W1608571122 @default.
• W2052193731 cites W1757163533 @default.
• W2052193731 cites W1949963417 @default.
• W2052193731 cites W1963886849 @default.
• W2052193731 cites W1965877343 @default.
• W2052193731 cites W1968009713 @default.
• W2052193731 cites W1976492411 @default.
• W2052193731 cites W1983478738 @default.
• W2052193731 cites W1990583841 @default.
• W2052193731 cites W1997347402 @default.
• W2052193731 cites W2007862497 @default.
• W2052193731 cites W2014164259 @default.
• W2052193731 cites W2020016523 @default.
• W2052193731 cites W2022090645 @default.
• W2052193731 cites W2034191899 @default.
• W2052193731 cites W2040494182 @default.
• W2052193731 cites W2041724479 @default.
• W2052193731 cites W2048426192 @default.
• W2052193731 cites W2049818607 @default.
• W2052193731 cites W2057705220 @default.
• W2052193731 cites W2062948593 @default.
• W2052193731 cites W2065892893 @default.
• W2052193731 cites W2072388933 @default.
• W2052193731 cites W2072752799 @default.
• W2052193731 cites W2073039960 @default.
• W2052193731 cites W2088480217 @default.
• W2052193731 cites W2092116189 @default.
• W2052193731 cites W2092727047 @default.
• W2052193731 cites W2125939444 @default.
• W2052193731 cites W2130386700 @default.
• W2052193731 cites W2414939181 @default.
• W2052193731 cites W4231615683 @default.
• W2052193731 cites W58690189 @default.
• W2052193731 cites W6913690 @default.
• W2052193731 doi "https://doi.org/10.1007/bf00485854" @default.
• W2052193731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6497832" @default.
• W2052193731 hasPublicationYear "1984" @default.
• W2052193731 type Work @default.
• W2052193731 sameAs 2052193731 @default.
• W2052193731 citedByCount "23" @default.
• W2052193731 countsByYear W20521937312016 @default.
• W2052193731 crossrefType "journal-article" @default.
• W2052193731 hasAuthorship W2052193731A5021216992 @default.
• W2052193731 hasAuthorship W2052193731A5025704724 @default.
• W2052193731 hasAuthorship W2052193731A5049296315 @default.
• W2052193731 hasAuthorship W2052193731A5059665300 @default.
• W2052193731 hasBestOaLocation W20521937312 @default.
• W2052193731 hasConcept C104317684 @default.
• W2052193731 hasConcept C143065580 @default.
• W2052193731 hasConcept C153911025 @default.
• W2052193731 hasConcept C181199279 @default.
• W2052193731 hasConcept C194101687 @default.
• W2052193731 hasConcept C20950039 @default.
• W2052193731 hasConcept C2776023528 @default.
• W2052193731 hasConcept C2776694085 @default.
• W2052193731 hasConcept C2776985229 @default.
• W2052193731 hasConcept C2777108182 @default.
• W2052193731 hasConcept C2777111502 @default.
• W2052193731 hasConcept C2777755551 @default.
• W2052193731 hasConcept C2777844706 @default.
• W2052193731 hasConcept C2778564976 @default.
• W2052193731 hasConcept C2780258809 @default.
• W2052193731 hasConcept C2781184954 @default.
• W2052193731 hasConcept C2781259782 @default.
• W2052193731 hasConcept C512185932 @default.
• W2052193731 hasConcept C54355233 @default.
• W2052193731 hasConcept C552990157 @default.
• W2052193731 hasConcept C55493867 @default.
• W2052193731 hasConcept C67705224 @default.
• W2052193731 hasConcept C86803240 @default.
• W2052193731 hasConceptScore W2052193731C104317684 @default.
• W2052193731 hasConceptScore W2052193731C143065580 @default.
• W2052193731 hasConceptScore W2052193731C153911025 @default.
• W2052193731 hasConceptScore W2052193731C181199279 @default.
• W2052193731 hasConceptScore W2052193731C194101687 @default.
• W2052193731 hasConceptScore W2052193731C20950039 @default.
• W2052193731 hasConceptScore W2052193731C2776023528 @default.
• W2052193731 hasConceptScore W2052193731C2776694085 @default.
• W2052193731 hasConceptScore W2052193731C2776985229 @default.
• W2052193731 hasConceptScore W2052193731C2777108182 @default.
• W2052193731 hasConceptScore W2052193731C2777111502 @default.
• W2052193731 hasConceptScore W2052193731C2777755551 @default.
• W2052193731 hasConceptScore W2052193731C2777844706 @default.
• W2052193731 hasConceptScore W2052193731C2778564976 @default.
• W2052193731 hasConceptScore W2052193731C2780258809 @default.
• W2052193731 hasConceptScore W2052193731C2781184954 @default.
• W2052193731 hasConceptScore W2052193731C2781259782 @default.
• W2052193731 hasConceptScore W2052193731C512185932 @default.

• next