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• W2052195617 abstract "The compatibility of d-amino acids with peptide elongation during translation has been examined in several studies. However, some of the studies have reported that d-amino acids are incompatible with translation, whereas others have reported that d-amino acids are incorporated into polypeptides. Here, we have reevaluated the incorporation of a series of d-amino acids into the nascent chain of short peptides with a reprogrammed genetic code by using the flexible in vitro translation (FIT) system. The FIT system enables the compatibility of each d-amino acid with elongation to be assessed quantitatively in the absence of potential competitors. The incorporation efficiencies were determined by Tricine-SDS-PAGE and the full-length peptide was detected by MALDI-TOF-MS. The d-amino acids were categorized into three groups based on their incorporation efficiencies relative to the corresponding l-amino acid. The d-isomers in group I showed efficiencies of 40% or higher (Ala, Ser, Cys, Met, Thr, His, Phe, and Tyr), and those in group II showed efficiencies of 10–40% (Asn, Gln, Val, and Leu). The d-amino acids in group III produced truncated peptides or no detectable full-length peptides (Arg, Lys, Asp, Glu, Ile, Trp, and Pro). When group I d-amino acids were used consecutively or were alternated with l-amino acids, this completely inhibited their elongation. However, when two or three l-amino acids were inserted between the d-amino acids, the double-incorporation efficiency was restored. Our results quantitatively reveal the compatibility of d-amino acids with peptide elongation and raise new questions about the mechanism of d-amino acid selection and incorporation by the ribosome." @default.
• W2052195617 created "2016-06-24" @default.
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• W2052195617 date "2013-01-25" @default.
• W2052195617 modified "2023-10-16" @default.
• W2052195617 title "Reevaluation of the <scp>d</scp>-Amino Acid Compatibility with the Elongation Event in Translation" @default.
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• W2052195617 doi "https://doi.org/10.1021/ja309570x" @default.
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