Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052203676> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2052203676 endingPage "28" @default.
- W2052203676 startingPage "21" @default.
- W2052203676 abstract "ABSTRACT. Semisynthetic human insulin (Novo) was compared with porcine insulin with regard to absorption from subcutaneous depots, blood glucose control and plasma insulin concentrations in patients, and the binding to insulin receptors of porcine and human origin. The binding affinities of semisynthetic human insulin and porcine insulin were identical with human erythrocyte receptors and receptors on porcine hepatocytes. The subcutaneous absorption of semisynthetic human and porcine 125 I‐labelled insulin both of soluble and lente type was identical. The metabolic control study was performed as a double‐blind crossover study in eight type I diabetics. They received semisynthetic human insulin and porcine insulin (of soluble as well as lente type) for 10 days each, the last 7 days in each period being the observation period. Blood glucose concentration was measured 9 times per 24 hours. No statistically significant differences were found between mean blood glucose levels at the 9 samplings or in the overall mean blood glucose concentration. Further, the blood glucose control was evaluated as a function of time by a computerized method for time series analysis of a complex dynamic system. This method described adequately each blood glucose value as a linear function of the immediately preceding blood glucose value and that measured 24 hours before. No difference was found between human and porcine insulin when the blood glucose control was assessed by this method. Plasma concentrations of total insulin (IRI) and free IRI before and 3 hours after the morning insulin injection were identical in the two treatment periods. It is concluded that human and porcine insulin can be interchanged in the treatment of diabetics without changing the dose." @default.
- W2052203676 created "2016-06-24" @default.
- W2052203676 creator A5011826407 @default.
- W2052203676 creator A5030109926 @default.
- W2052203676 creator A5050737343 @default.
- W2052203676 creator A5054792989 @default.
- W2052203676 creator A5081179580 @default.
- W2052203676 date "1982-01-12" @default.
- W2052203676 modified "2023-09-27" @default.
- W2052203676 title "The Biological Properties of Human Insulin" @default.
- W2052203676 cites W114840752 @default.
- W2052203676 cites W1530198907 @default.
- W2052203676 cites W1972457434 @default.
- W2052203676 cites W1976380177 @default.
- W2052203676 cites W1991711296 @default.
- W2052203676 cites W1995179313 @default.
- W2052203676 cites W2012102204 @default.
- W2052203676 cites W2019823315 @default.
- W2052203676 cites W2026710843 @default.
- W2052203676 cites W2028040293 @default.
- W2052203676 cites W2044952485 @default.
- W2052203676 cites W2049441274 @default.
- W2052203676 cites W2061388550 @default.
- W2052203676 cites W2062162337 @default.
- W2052203676 cites W2064616660 @default.
- W2052203676 cites W2066673941 @default.
- W2052203676 cites W2067325001 @default.
- W2052203676 cites W2070505019 @default.
- W2052203676 cites W2072482644 @default.
- W2052203676 cites W2078018484 @default.
- W2052203676 cites W2111640985 @default.
- W2052203676 cites W2113850105 @default.
- W2052203676 cites W2119891717 @default.
- W2052203676 cites W2130020651 @default.
- W2052203676 cites W2132689253 @default.
- W2052203676 cites W2313706041 @default.
- W2052203676 cites W4249977138 @default.
- W2052203676 doi "https://doi.org/10.1111/j.0954-6820.1982.tb03163.x" @default.
- W2052203676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6751025" @default.
- W2052203676 hasPublicationYear "1982" @default.
- W2052203676 type Work @default.
- W2052203676 sameAs 2052203676 @default.
- W2052203676 citedByCount "14" @default.
- W2052203676 countsByYear W20522036762012 @default.
- W2052203676 countsByYear W20522036762020 @default.
- W2052203676 crossrefType "journal-article" @default.
- W2052203676 hasAuthorship W2052203676A5011826407 @default.
- W2052203676 hasAuthorship W2052203676A5030109926 @default.
- W2052203676 hasAuthorship W2052203676A5050737343 @default.
- W2052203676 hasAuthorship W2052203676A5054792989 @default.
- W2052203676 hasAuthorship W2052203676A5081179580 @default.
- W2052203676 hasConcept C126322002 @default.
- W2052203676 hasConcept C134018914 @default.
- W2052203676 hasConcept C170493617 @default.
- W2052203676 hasConcept C19720800 @default.
- W2052203676 hasConcept C2779306644 @default.
- W2052203676 hasConcept C3019948211 @default.
- W2052203676 hasConcept C71924100 @default.
- W2052203676 hasConceptScore W2052203676C126322002 @default.
- W2052203676 hasConceptScore W2052203676C134018914 @default.
- W2052203676 hasConceptScore W2052203676C170493617 @default.
- W2052203676 hasConceptScore W2052203676C19720800 @default.
- W2052203676 hasConceptScore W2052203676C2779306644 @default.
- W2052203676 hasConceptScore W2052203676C3019948211 @default.
- W2052203676 hasConceptScore W2052203676C71924100 @default.
- W2052203676 hasIssue "1-2" @default.
- W2052203676 hasLocation W20522036761 @default.
- W2052203676 hasLocation W20522036762 @default.
- W2052203676 hasOpenAccess W2052203676 @default.
- W2052203676 hasPrimaryLocation W20522036761 @default.
- W2052203676 hasRelatedWork W1983641721 @default.
- W2052203676 hasRelatedWork W1995945960 @default.
- W2052203676 hasRelatedWork W2026226896 @default.
- W2052203676 hasRelatedWork W2032033851 @default.
- W2052203676 hasRelatedWork W2041678535 @default.
- W2052203676 hasRelatedWork W2058152093 @default.
- W2052203676 hasRelatedWork W2066345847 @default.
- W2052203676 hasRelatedWork W2089387278 @default.
- W2052203676 hasRelatedWork W2095179743 @default.
- W2052203676 hasRelatedWork W2130904138 @default.
- W2052203676 hasVolume "212" @default.
- W2052203676 isParatext "false" @default.
- W2052203676 isRetracted "false" @default.
- W2052203676 magId "2052203676" @default.
- W2052203676 workType "article" @default.