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- W2052204033 abstract "1H magnetic resonance spectroscopy was used to compare brain metabolism in 540 elderly persons, stratified by sex and age (60–90 years old). An 8 × 8 × 2 cm3 supraventricular brain volume, a transverse plane parallel to the canthomeatal line, was examined by automated 1H chemical shift imaging [point-resolved spectroscopy (PRESS), TE of 35 msec]. Regional choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA) peak areas in the 518 successful examinations (96%) were studied by division through the total area of the particular metabolite in each spectral map. This procedure eliminated intersubject variance, maximized intervoxel variance (26 ≤ F ≤ 149, P < 0.0001) and reduced the standard deviations in the voxel metabolite signals threefold. Normalized signals in women (n = 257) and men (n = 261) differed in 9 (Cho/ΣCho), 8 (Cr/ΣCr), and 10 (NAA/ΣNAA) of 36 voxels examined (P ≤ 0.001). In the cingulate gyrus Cho/ΣCho, Cr/ΣCr, and NAA/ΣNAA were reduced in men compared with women. These findings are consistent with a sex-related reduction of glucose metabolism in the same brain lobe revealed by positron emission tomography. Magn Reson Med 42:24–31, 1999. © 1999 Wiley-Liss, Inc." @default.
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- W2052204033 date "1999-07-01" @default.
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- W2052204033 title "1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men" @default.
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- W2052204033 doi "https://doi.org/10.1002/(sici)1522-2594(199907)42:1<24::aid-mrm5>3.0.co;2-3" @default.
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