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- W2052206514 startingPage "275" @default.
- W2052206514 abstract "Three to five week old Charles River white rats of the same litters were intraperitoneally injected with a commercial sample of 2, 4-dichlorophenoxyacetic acid (2, 4-D) dissolved in dimethyl-sulfoxide, in concentration ranging from 25 to 350μg/kg. Eight treated animals and one control were used for 4-hr exposure periods to determine the direct effect of 2, 4-D on chromosomes. Nine treated and one control animals were used for the 24-hr exposure periods to determine direct and indirect effects of 2, 4-D. Data were taken from 50 cells with adequate chromosome spreads for each experimental animal in each of the three replicates. Statistical analysis (ANOVA and Dunnett's Multiple Comparisons Test) revealed a significant increase in the rate of chromosome aberrations at 100μg/kg, both for 4-hr and 24-hr tests. Generally, at other treatment levels the rate of chromosome aberrations was higher though statistically not significant. It appears that 2, 4-D induced clastogenicity peaks at 100μg/kg." @default.
- W2052206514 created "2016-06-24" @default.
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- W2052206514 date "1987-01-01" @default.
- W2052206514 modified "2023-10-05" @default.
- W2052206514 title "Induced clastogenicity in white rats by the herbicide 2,4-D." @default.
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- W2052206514 doi "https://doi.org/10.1508/cytologia.52.275" @default.
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