FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052207626> ?p ?o ?g. }

• W2052207626 endingPage "1010" @default.
• W2052207626 startingPage "1004" @default.
• W2052207626 abstract "The present study was devised to elucidate the influence of prolonged cold ischemia on the development of chronic transplant dysfunction (CTD) in kidney isografts (Brown Norway-->Brown Norway; BN-->BN) and in kidney allografts (BN-->Wistar Agouti/ Rij [WAG]) under temporary cyclosporine (CsA) therapy.To induce ischemic injury, BN donor kidneys were preserved for 24 hr in 4 degrees C University of Wisconsin solution before transplantation. Renal function (proteinuria), histomorphology according to the BANFF criteria for CTD, and infiltrating cells were assessed. Grafts were examined both early at days 2, 3, 6, and 10, and late at week 26 (allografts) or at week 52 (isografts).Nonischemic isografts preserved a normal function and morphology. Ischemic isografts developed a progressive proteinuria over time and demonstrated significantly more glomerulopathy with macrophage (Me) infiltration and intimal hyperplasia than nonischemic controls at week 52. During the initial 10 days, there was an increased infiltration of MHC class II+ cells, predominantly CD4+ cells and Mphi, coinciding with up-regulated intercellular adhesion molecule-1 expression. CsA treatment in ischemic isografts inhibited infiltration of MHC II+ cells in the early stage, which was accompanied by significantly less renal damage at week 52 compared with untreated controls (proteinuria: 59+/-8 vs. 134+/-19 mg/24 hr; BANFF score: 2.8+/-0.4 vs. 4.3+/-1.0). Under CsA therapy, 24-hr cold ischemia of the allograft affected neither the onset or progress of proteinuria, nor the histomorphology (BANFF score: 7.8+/-2.4 vs. 7.3+/-1.9). In both ischemic and nonischemic allografts, intercellular adhesion molecule-1 expression and mononuclear cell infiltration (CD4, CD8, Mphi was abundantly present during the first 10 days and function deteriorated rapidly.Prolonged cold ischemia plays a role in the induction of CTD, but its deleterious effect can be successfully inhibited by CsA. Therefore, the alloantigeneic stimulus is the overriding component in the multifactorial pathogenesis of CTD." @default.
• W2052207626 created "2016-06-24" @default.
• W2052207626 creator A5028813168 @default.
• W2052207626 creator A5044567914 @default.
• W2052207626 creator A5052145533 @default.
• W2052207626 creator A5084068344 @default.
• W2052207626 creator A5086856138 @default.
• W2052207626 date "1999-10-01" @default.
• W2052207626 modified "2023-10-06" @default.
• W2052207626 title "LATE GRAFT DYSFUNCTION AFTER PROLONGED COLD ISCHEMIA OF THE DONOR KIDNEY" @default.
• W2052207626 cites W162447880 @default.
• W2052207626 cites W1965945233 @default.
• W2052207626 cites W1976650281 @default.
• W2052207626 cites W1983053626 @default.
• W2052207626 cites W1990038658 @default.
• W2052207626 cites W1994370426 @default.
• W2052207626 cites W1996867825 @default.
• W2052207626 cites W2003700045 @default.
• W2052207626 cites W2023893380 @default.
• W2052207626 cites W2025439449 @default.
• W2052207626 cites W2036007940 @default.
• W2052207626 cites W2043551147 @default.
• W2052207626 cites W2045064669 @default.
• W2052207626 cites W2054382681 @default.
• W2052207626 cites W2071195480 @default.
• W2052207626 cites W2074961134 @default.
• W2052207626 cites W2075874065 @default.
• W2052207626 cites W2085665934 @default.
• W2052207626 cites W2086417798 @default.
• W2052207626 cites W2092711749 @default.
• W2052207626 cites W2117871749 @default.
• W2052207626 cites W2121454052 @default.
• W2052207626 cites W4250399467 @default.
• W2052207626 doi "https://doi.org/10.1097/00007890-199910150-00018" @default.
• W2052207626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10532542" @default.
• W2052207626 hasPublicationYear "1999" @default.
• W2052207626 type Work @default.
• W2052207626 sameAs 2052207626 @default.
• W2052207626 citedByCount "32" @default.
• W2052207626 countsByYear W20522076262012 @default.
• W2052207626 countsByYear W20522076262014 @default.
• W2052207626 countsByYear W20522076262022 @default.
• W2052207626 crossrefType "journal-article" @default.
• W2052207626 hasAuthorship W2052207626A5028813168 @default.
• W2052207626 hasAuthorship W2052207626A5044567914 @default.
• W2052207626 hasAuthorship W2052207626A5052145533 @default.
• W2052207626 hasAuthorship W2052207626A5084068344 @default.
• W2052207626 hasAuthorship W2052207626A5086856138 @default.
• W2052207626 hasBestOaLocation W20522076261 @default.
• W2052207626 hasConcept C121332964 @default.
• W2052207626 hasConcept C126322002 @default.
• W2052207626 hasConcept C126894567 @default.
• W2052207626 hasConcept C134018914 @default.
• W2052207626 hasConcept C142724271 @default.
• W2052207626 hasConcept C153400128 @default.
• W2052207626 hasConcept C159641895 @default.
• W2052207626 hasConcept C2778653478 @default.
• W2052207626 hasConcept C2779561371 @default.
• W2052207626 hasConcept C2780091579 @default.
• W2052207626 hasConcept C2780303639 @default.
• W2052207626 hasConcept C2911091166 @default.
• W2052207626 hasConcept C541997718 @default.
• W2052207626 hasConcept C71924100 @default.
• W2052207626 hasConcept C97355855 @default.
• W2052207626 hasConceptScore W2052207626C121332964 @default.
• W2052207626 hasConceptScore W2052207626C126322002 @default.
• W2052207626 hasConceptScore W2052207626C126894567 @default.
• W2052207626 hasConceptScore W2052207626C134018914 @default.
• W2052207626 hasConceptScore W2052207626C142724271 @default.
• W2052207626 hasConceptScore W2052207626C153400128 @default.
• W2052207626 hasConceptScore W2052207626C159641895 @default.
• W2052207626 hasConceptScore W2052207626C2778653478 @default.
• W2052207626 hasConceptScore W2052207626C2779561371 @default.
• W2052207626 hasConceptScore W2052207626C2780091579 @default.
• W2052207626 hasConceptScore W2052207626C2780303639 @default.
• W2052207626 hasConceptScore W2052207626C2911091166 @default.
• W2052207626 hasConceptScore W2052207626C541997718 @default.
• W2052207626 hasConceptScore W2052207626C71924100 @default.
• W2052207626 hasConceptScore W2052207626C97355855 @default.
• W2052207626 hasIssue "7" @default.
• W2052207626 hasLocation W20522076261 @default.
• W2052207626 hasLocation W20522076262 @default.
• W2052207626 hasOpenAccess W2052207626 @default.
• W2052207626 hasPrimaryLocation W20522076261 @default.
• W2052207626 hasRelatedWork W1971368128 @default.
• W2052207626 hasRelatedWork W2104709702 @default.
• W2052207626 hasRelatedWork W2122079536 @default.
• W2052207626 hasRelatedWork W2165568411 @default.
• W2052207626 hasRelatedWork W2353153605 @default.
• W2052207626 hasRelatedWork W2416120169 @default.
• W2052207626 hasRelatedWork W2418451490 @default.
• W2052207626 hasRelatedWork W2790532628 @default.
• W2052207626 hasRelatedWork W3205964248 @default.
• W2052207626 hasRelatedWork W4320929188 @default.
• W2052207626 hasVolume "68" @default.
• W2052207626 isParatext "false" @default.
• W2052207626 isRetracted "false" @default.
• W2052207626 magId "2052207626" @default.

• next