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- W2052209777 abstract "To the Editor: We share the concerns that Rappaport et al. express in their Perspective article in this issue of the Journal regarding possible relationships between anesthetic agents and neurologic damage in young children. However, clinicians are challenged with extrapolating neurodevelopmental stages and behavioral correlates from animal models to human infants. Studies in animals reveal worrisome neuronal apoptosis after anesthesia, raising questions about whether pediatric anesthesiologists should change their practice and what they should tell parents. Studies in animals involve prolonged exposure to anesthetics in high doses with variable monitoring and no surgical stress. Furthermore, translating stages of brain development . . ." @default.
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- W2052209777 date "2011-04-14" @default.
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- W2052209777 title "Anesthesia in Children — Limitations of the Data on Neurotoxicity" @default.
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- W2052209777 doi "https://doi.org/10.1056/nejmc1102479" @default.
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