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• W2052221145 abstract "Summary The objective of this work was to study the role of mannose-binding lectin (MBL) and C-reactive protein (CRP) in pneumococcal pneumonia, to determine whether MBL acts as an acute-phase reactant and whether the severity of the disease correlates with MBL levels. The study comprised 100 patients with pneumococcal pneumonia. The pneumonia severity score was calculated and graded into a risk class of mortality (Fine scale). The MBL genotypes and the levels of MBL and CRP at the acute and recovery phases were determined. Fifty patients with the wild-type MBL genotype showed higher MBL levels in each phase (P &lt; 0·001) and an increased risk to developing bacteraemia, odds ratio (OR) 2·74, 95% confidence interval (CI) 1·01–7·52) (P = 0·02), but this did not correlate with the pneumonia severity class. CRP levels in the acute phase, 79·53 mg/l [standard deviation (s.d.) 106·93], were higher in the subjects with positive blood cultures (P = 0·003), and remained higher [20·12 mg/l (s.d. 31·90)] in the group of patients with an underlying disease (P = 0·01). No correlation was observed between the levels of MBL and CRP in each phase, or with the pneumonia severity score. We cannot conclude that MBL acts uniformly as an acute-phase reactant in pneumococcal pneumonia. MBL levels do not correlate well with the severity of the pneumonia. The risk of developing bacteraemia could be enhanced in individuals with the wild-type MBL genotype." @default.
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• W2052221145 date "2006-06-23" @default.
• W2052221145 modified "2023-10-01" @default.
• W2052221145 title "Mannose-binding lectin does not act as an acute-phase reactant in adults with community-acquired pneumococcal pneumonia" @default.
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• W2052221145 doi "https://doi.org/10.1111/j.1365-2249.2006.03140.x" @default.
• W2052221145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809673" @default.
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