Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052222785> ?p ?o ?g. }
- W2052222785 endingPage "223" @default.
- W2052222785 startingPage "213" @default.
- W2052222785 abstract "IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of Jgamma segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCRgamma genes and partially rescues T cell development from IL-7R(-/-) T cell precursors, especially in favor of gammadelta T cells. Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription." @default.
- W2052222785 created "2016-06-24" @default.
- W2052222785 creator A5002849092 @default.
- W2052222785 creator A5014521282 @default.
- W2052222785 creator A5019039647 @default.
- W2052222785 creator A5026278665 @default.
- W2052222785 creator A5035451612 @default.
- W2052222785 creator A5054419460 @default.
- W2052222785 creator A5054497666 @default.
- W2052222785 creator A5071627434 @default.
- W2052222785 creator A5082894731 @default.
- W2052222785 date "1999-08-01" @default.
- W2052222785 modified "2023-10-02" @default.
- W2052222785 title "Induction of Germline Transcription in the TCRγ Locus by Stat5" @default.
- W2052222785 cites W1514059110 @default.
- W2052222785 cites W1609966422 @default.
- W2052222785 cites W1670107136 @default.
- W2052222785 cites W1917578864 @default.
- W2052222785 cites W1972658032 @default.
- W2052222785 cites W1992048975 @default.
- W2052222785 cites W1993932758 @default.
- W2052222785 cites W1995297089 @default.
- W2052222785 cites W1998373798 @default.
- W2052222785 cites W2002573132 @default.
- W2052222785 cites W2008661167 @default.
- W2052222785 cites W2011030679 @default.
- W2052222785 cites W2024208188 @default.
- W2052222785 cites W2026708020 @default.
- W2052222785 cites W2034433166 @default.
- W2052222785 cites W2041742410 @default.
- W2052222785 cites W2042050831 @default.
- W2052222785 cites W2046005089 @default.
- W2052222785 cites W2062356998 @default.
- W2052222785 cites W2065388713 @default.
- W2052222785 cites W2069442989 @default.
- W2052222785 cites W2083802827 @default.
- W2052222785 cites W2085555998 @default.
- W2052222785 cites W2088534912 @default.
- W2052222785 cites W2091092658 @default.
- W2052222785 cites W2091604878 @default.
- W2052222785 cites W2093712109 @default.
- W2052222785 cites W2094096693 @default.
- W2052222785 cites W2094899168 @default.
- W2052222785 cites W2096632716 @default.
- W2052222785 cites W2131666890 @default.
- W2052222785 cites W2143768331 @default.
- W2052222785 cites W2158169658 @default.
- W2052222785 cites W2336183884 @default.
- W2052222785 cites W2423833205 @default.
- W2052222785 cites W56851753 @default.
- W2052222785 doi "https://doi.org/10.1016/s1074-7613(00)80096-5" @default.
- W2052222785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10485656" @default.
- W2052222785 hasPublicationYear "1999" @default.
- W2052222785 type Work @default.
- W2052222785 sameAs 2052222785 @default.
- W2052222785 citedByCount "115" @default.
- W2052222785 countsByYear W20522227852012 @default.
- W2052222785 countsByYear W20522227852013 @default.
- W2052222785 countsByYear W20522227852014 @default.
- W2052222785 countsByYear W20522227852015 @default.
- W2052222785 countsByYear W20522227852016 @default.
- W2052222785 countsByYear W20522227852017 @default.
- W2052222785 countsByYear W20522227852019 @default.
- W2052222785 countsByYear W20522227852020 @default.
- W2052222785 countsByYear W20522227852021 @default.
- W2052222785 countsByYear W20522227852022 @default.
- W2052222785 crossrefType "journal-article" @default.
- W2052222785 hasAuthorship W2052222785A5002849092 @default.
- W2052222785 hasAuthorship W2052222785A5014521282 @default.
- W2052222785 hasAuthorship W2052222785A5019039647 @default.
- W2052222785 hasAuthorship W2052222785A5026278665 @default.
- W2052222785 hasAuthorship W2052222785A5035451612 @default.
- W2052222785 hasAuthorship W2052222785A5054419460 @default.
- W2052222785 hasAuthorship W2052222785A5054497666 @default.
- W2052222785 hasAuthorship W2052222785A5071627434 @default.
- W2052222785 hasAuthorship W2052222785A5082894731 @default.
- W2052222785 hasBestOaLocation W20522227851 @default.
- W2052222785 hasConcept C104317684 @default.
- W2052222785 hasConcept C109825262 @default.
- W2052222785 hasConcept C138885662 @default.
- W2052222785 hasConcept C153911025 @default.
- W2052222785 hasConcept C156695909 @default.
- W2052222785 hasConcept C179926584 @default.
- W2052222785 hasConcept C19317047 @default.
- W2052222785 hasConcept C2776090121 @default.
- W2052222785 hasConcept C2779391668 @default.
- W2052222785 hasConcept C2780254951 @default.
- W2052222785 hasConcept C41895202 @default.
- W2052222785 hasConcept C54355233 @default.
- W2052222785 hasConcept C84597430 @default.
- W2052222785 hasConcept C86339819 @default.
- W2052222785 hasConcept C86803240 @default.
- W2052222785 hasConcept C8891405 @default.
- W2052222785 hasConcept C95444343 @default.
- W2052222785 hasConceptScore W2052222785C104317684 @default.
- W2052222785 hasConceptScore W2052222785C109825262 @default.
- W2052222785 hasConceptScore W2052222785C138885662 @default.
- W2052222785 hasConceptScore W2052222785C153911025 @default.