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• W2052225522 abstract "The specialized transport properties of the thick ascending limb of Henle's loop (TALH) enable this segment of the nephron to dissociate salt and water absorption. Sodium chloride absorption by the cortical (cTALH) and medullary (mTALH) thick ascending limb accounts for urinary dilution, since each of these segments is virtually water–impermeable. Salt absorption by the mTALH also contributes to medullary interstitial hypertonicity, supplies the energy for the single effect of countercurrent multiplication, and hence modulates urinary concentrating mechanisms. The medullary (mTALH) and cortical (cTALH) portions of the TALH are clearly heterogeneous, and can be distinguished on the basis of morphological [1, 2], biochemical [3–6] and functional [7] differences. This article will focus particularly on the transport functions of the medullary segment. The specific issues discussed will include the mechanism of NaCl absorption by the mTALH, the enhancement of this salt absorptive process by antidiuretic hormone (ADH), at least in certain mammalian species, and the major factors that appear to regulate or modulate both ADH-dependent and -independent NaCl transport processes. Sufficient information is currently available which indicates that these modulating factors provide feedback loops which sense interstitial osmolality and serve as a means of controlling the magnitude of interstitial hypertonicity, and hence concentrating power." @default.
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• W2052225522 date "1987-02-01" @default.
• W2052225522 modified "2023-10-15" @default.
• W2052225522 title "The medullary thick limb: Function and modulation of the single–effect multiplier" @default.
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• W2052225522 doi "https://doi.org/10.1038/ki.1987.38" @default.
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