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- W2052227192 abstract "See article by Lin et al. [2] (pages 51–58) in this issue. The small GTPase RhoA and its downstream target Rho kinase (Rho-associated coiled-coil protein kinase or ROCK) are involved in cell contraction and a variety of other cellular processes via modulation of actin cytoskeletal assembly. Several studies, including investigations in humans, have clearly shown an important pathophysiological role of this pathway in the cardiovascular system and in disease states such as hypertension, heart failure, stroke, and diabetes [1]. The RhoA/ROCK pathway is best described in smooth muscle cells, where it mediates calcium sensitization and thereby enhances and sustains contraction. However, the role of the RhoA/ROCK pathway in the myocardium is less well understood. Most studies on RhoA/ROCK in the heart address its involvement in cardiac hypertrophy and remodelling, and chronic inhibition of the pathway may prevent these long-term effects. In the current issue of Cardiovascular Research Lin et al. [2] describe a possible role of the RhoA/ROCK pathway in the contractile function of diabetic rat heart. These authors report that the decreased contractile function of hearts of diabetic animals was associated with an increased expression and activity of RhoA and ROCK. Interestingly, acute inhibition of ROCK improved cardiac performance in vivo … * Corresponding author. Tel.: +31 20 5667622. s.l.peters{at}amc.uva.nl" @default.
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- W2052227192 title "The RhoA/Rho kinase pathway in the myocardium" @default.
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- W2052227192 doi "https://doi.org/10.1016/j.cardiores.2007.04.016" @default.
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