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- W2052249058 abstract "17β-HSD2 is a promising new target for the treatment of osteoporosis. In this paper, a rational strategy to overcome the metabolic liability in the 2,5-thiophene amide class of 17β-HSD2 inhibitors is described, and the biological activity of the new inhibitors. Applying different strategies, as lowering the cLogP or modifying the structures of the molecules, compounds 27, 31 and 35 with strongly improved metabolic stability were obtained. For understanding biotransformation in the 2,5-thiophene amide class the main metabolic pathways of three properly selected compounds were elucidated." @default.
- W2052249058 created "2016-06-24" @default.
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- W2052249058 date "2014-11-01" @default.
- W2052249058 modified "2023-10-18" @default.
- W2052249058 title "Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β-hydroxysteroid dehydrogenase type 2 inhibitors" @default.
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- W2052249058 doi "https://doi.org/10.1016/j.ejmech.2014.09.061" @default.
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