Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052281331> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2052281331 endingPage "82" @default.
- W2052281331 startingPage "82" @default.
- W2052281331 abstract "Neuroprotective, antioxidant, anticonvulsant, and analgesic effects of Nigella sativa (NS) have been previously shown. The interaction of NS with opioid system has also been reported. In the present study, the effects of NS hydro-alcoholic extract on the acquisition and expression of morphine-induced conditioned place preference (CPP) in rats were evaluated.CPP was induced by injection of morphine (5 mg/kg, i.p.) on three consecutive days in compartment A of the CPP apparatus. Injection of NS extract (200 and 400 mg/kg, i.p.) 60 min before morphine administration on the conditioning days and 60 min before the post-conditioning phase was done for the evaluation of acquisition and expression effects, respectively. Conditioning effect of NS extract was also evaluated by injection of extract (200 or 400 mg/kg, i.p.) in the conditioning phase, instead of morphine in different groups. The difference in time which the animals spent in compartment A on the day before conditioning and the days after conditioning was determined and compared between groups.The time spent by the rats in compartment A in the morphine group was greater than that in the saline group (P < 0.01). Both doses of NS extract decreased acquisition of morphine-induced CPP (P < 0.01 and P < 0.001), but had no significant effect on the expression of morphine CPP. Higher dose of the extract (400 mg) showed a significant conditioning effect which was comparable to the effect of morphine.The results of the present study showed that the hydro-alcoholic extract of NS has conditioning effect. It also decreased acquisition, but had no significant effect on the expression of morphine CPP." @default.
- W2052281331 created "2016-06-24" @default.
- W2052281331 creator A5017311650 @default.
- W2052281331 creator A5021569315 @default.
- W2052281331 creator A5025334703 @default.
- W2052281331 creator A5046216320 @default.
- W2052281331 creator A5059802660 @default.
- W2052281331 creator A5078233565 @default.
- W2052281331 creator A5081215156 @default.
- W2052281331 creator A5085116378 @default.
- W2052281331 date "2012-01-01" @default.
- W2052281331 modified "2023-09-22" @default.
- W2052281331 title "Nigella sativa extract affects conditioned place preference induced by morphine in rats" @default.
- W2052281331 doi "https://doi.org/10.4103/0257-7941.118537" @default.
- W2052281331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3807962" @default.
- W2052281331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24167332" @default.
- W2052281331 hasPublicationYear "2012" @default.
- W2052281331 type Work @default.
- W2052281331 sameAs 2052281331 @default.
- W2052281331 citedByCount "10" @default.
- W2052281331 countsByYear W20522813312014 @default.
- W2052281331 countsByYear W20522813312015 @default.
- W2052281331 countsByYear W20522813312016 @default.
- W2052281331 countsByYear W20522813312017 @default.
- W2052281331 countsByYear W20522813312018 @default.
- W2052281331 countsByYear W20522813312020 @default.
- W2052281331 countsByYear W20522813312021 @default.
- W2052281331 crossrefType "journal-article" @default.
- W2052281331 hasAuthorship W2052281331A5017311650 @default.
- W2052281331 hasAuthorship W2052281331A5021569315 @default.
- W2052281331 hasAuthorship W2052281331A5025334703 @default.
- W2052281331 hasAuthorship W2052281331A5046216320 @default.
- W2052281331 hasAuthorship W2052281331A5059802660 @default.
- W2052281331 hasAuthorship W2052281331A5078233565 @default.
- W2052281331 hasAuthorship W2052281331A5081215156 @default.
- W2052281331 hasAuthorship W2052281331A5085116378 @default.
- W2052281331 hasBestOaLocation W20522813311 @default.
- W2052281331 hasConcept C105795698 @default.
- W2052281331 hasConcept C126322002 @default.
- W2052281331 hasConcept C170493617 @default.
- W2052281331 hasConcept C185592680 @default.
- W2052281331 hasConcept C2777389121 @default.
- W2052281331 hasConcept C2777397205 @default.
- W2052281331 hasConcept C2780820201 @default.
- W2052281331 hasConcept C2781063702 @default.
- W2052281331 hasConcept C33923547 @default.
- W2052281331 hasConcept C35124327 @default.
- W2052281331 hasConcept C42219234 @default.
- W2052281331 hasConcept C45262634 @default.
- W2052281331 hasConcept C71924100 @default.
- W2052281331 hasConcept C98274493 @default.
- W2052281331 hasConceptScore W2052281331C105795698 @default.
- W2052281331 hasConceptScore W2052281331C126322002 @default.
- W2052281331 hasConceptScore W2052281331C170493617 @default.
- W2052281331 hasConceptScore W2052281331C185592680 @default.
- W2052281331 hasConceptScore W2052281331C2777389121 @default.
- W2052281331 hasConceptScore W2052281331C2777397205 @default.
- W2052281331 hasConceptScore W2052281331C2780820201 @default.
- W2052281331 hasConceptScore W2052281331C2781063702 @default.
- W2052281331 hasConceptScore W2052281331C33923547 @default.
- W2052281331 hasConceptScore W2052281331C35124327 @default.
- W2052281331 hasConceptScore W2052281331C42219234 @default.
- W2052281331 hasConceptScore W2052281331C45262634 @default.
- W2052281331 hasConceptScore W2052281331C71924100 @default.
- W2052281331 hasConceptScore W2052281331C98274493 @default.
- W2052281331 hasIssue "2" @default.
- W2052281331 hasLocation W20522813311 @default.
- W2052281331 hasLocation W20522813312 @default.
- W2052281331 hasLocation W20522813313 @default.
- W2052281331 hasLocation W20522813314 @default.
- W2052281331 hasOpenAccess W2052281331 @default.
- W2052281331 hasPrimaryLocation W20522813311 @default.
- W2052281331 hasRelatedWork W2001784761 @default.
- W2052281331 hasRelatedWork W2009638672 @default.
- W2052281331 hasRelatedWork W2009937195 @default.
- W2052281331 hasRelatedWork W2013924762 @default.
- W2052281331 hasRelatedWork W2030835553 @default.
- W2052281331 hasRelatedWork W2044221683 @default.
- W2052281331 hasRelatedWork W2073860477 @default.
- W2052281331 hasRelatedWork W2077444501 @default.
- W2052281331 hasRelatedWork W4206871862 @default.
- W2052281331 hasRelatedWork W4287435042 @default.
- W2052281331 hasVolume "32" @default.
- W2052281331 isParatext "false" @default.
- W2052281331 isRetracted "false" @default.
- W2052281331 magId "2052281331" @default.
- W2052281331 workType "article" @default.