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• W2052292082 abstract "Downregulation of the c-myc gene in HL-60 cells is associated with growth inhibition and induction of differentiation. Previous studies have reported that the growth inhibitors TGFβ and TNFα downregulate c-myc mRNA levels, suggesting the possibility that these agents may exert some of their phenotypic effects via c-myc downregulation. Our study demonstrates that although both growth inhibitors produce a similar decrease in c-myc protein synthesis, TNFα produces a greater growth inhibition and differentiation induction in HL-60 cells. Combined addition of anti-myc oligomer with either growth inhibitor produces no additive effect. In fact, 4 μM anti-myc oligomer produces the same growth and differentiation effects as does 10 ng/ml TGFβ1. We conclude that downregulation of c-myc expression represents a common mechanism of growth inhibition by TGFβ and TNFα, but that TNFα possesses an additional effect that is independent of c-myc expression." @default.
• W2052292082 created "2016-06-24" @default.
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• W2052292082 date "1991-02-01" @default.
• W2052292082 modified "2023-10-18" @default.
• W2052292082 title "Antisense inhibition of c-myc expression reveals common and distinct mechanisms of growth inhibition by TGFβ and TNFα" @default.
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• W2052292082 doi "https://doi.org/10.1002/jcb.240450210" @default.
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