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- W205229671 abstract "It has been speculated that a reaction-diffusion mechanism is working to make the periodic pattern of chondrogenesis during digit formation in limb development. One drawback in this hypothesis is that digits appear sequentially from posterior to anterior direction (except the fifth digit) in vivo, whereas the entire structure should appear simultaneously in the reaction-diffusion model. To explain the sequential appearance of digits we hypothesised that the parameter of the reaction term in the reaction-diffusion model should be different at the ZPA region, and undertook micromass culture of various parts of the mouse embryonic d 10.5 limb bud. The chondrogenic area appeared like spots when we cultured cells from the posterior part of the limb bud, whereas the chondrogenic area appeared like stripes when we cultured cells from other parts of the limb bud. To confirm this tendency, we developed an automated method to detect quantitatively the continuity of the periodic pattern using an image-processing technique, and confirmed that a statistically significant difference can be detected between the chondrogenic patterns generated by cells from different part of the limb bud. This kind of change in pattern can be reproduced in a computer simulation by changing the reaction term of the reaction-diffusion model, and we can similarly reproduce the sequential appearance of structures by changing this parameter of one end of the limb field. A similar kind of pattern change could be obtained using all-transretinoic acid, but currently we could not detect a change due to Sonic Hedgehog treatment. These results suggest that the ZPA region can influence the reaction-diffusion mechanism in the limb bud in vivo." @default.
- W205229671 created "2016-06-24" @default.
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- W205229671 date "2002-11-01" @default.
- W205229671 modified "2023-09-23" @default.
- W205229671 title "P5 Difference of chondrogenic pattern of cultured limb mesenchyme taken from various part of the limb bud." @default.
- W205229671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1570927" @default.
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