FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052319364> ?p ?o ?g. }

• W2052319364 endingPage "23" @default.
• W2052319364 startingPage "13" @default.
• W2052319364 abstract "Using the rat chronic constriction injury (CCI) pain model, we evaluated whether nitrous oxide (N2O), a gas shown to have potent anti-hyperalgesic properties, may alleviate neuropathic pain. Mechanical nociceptive threshold was estimated using the paw pressure vocalization test. Thermal allodynia was challenged by measuring the struggle latency by immersion of the hind paw in a 10°C water bath. A single 50% N2O exposure for 1 hour, 15 minutes not only induced potent anti-nociception during N2O exposure but also provoked a delayed and sustained reduction (37% to 46%) of pain hypersensitivity of the injured hind paw and abolished pain hypersensitivity of the contralateral uninjured hind paw for at least 1 month. Thermal allodynia was completely prevented by a single N2O exposure. A preadministration of naltrexone, which markedly reduced acute N2O-induced anti-nociception, did not affect the persistent reduction of hyperalgesia. The administration of naltrexone in N2O-treated rats, 1 week after the gas exposure, did not induce any effect. This suggests that the long-lasting effect of N2O was not due to its prior acute analgesic effect and was independent of endogenous opioid systems. These data suggest that 50% N2O exposure could be an efficient and safe strategy for alleviating neuropathic pain in a persistent manner. Perspective Because a single 50% N2O exposure induced a persistent reduction of hyperalgesia-allodynia in a rat neuropathic pain model, clinical trials must be developed for evaluating the N2O effects in patients with neuropathic pain. The ability of N2O to potentiate analgesic effects of other drugs also must be evaluated." @default.
• W2052319364 created "2016-06-24" @default.
• W2052319364 creator A5010468125 @default.
• W2052319364 creator A5013988554 @default.
• W2052319364 creator A5030865521 @default.
• W2052319364 creator A5073839685 @default.
• W2052319364 creator A5090149661 @default.
• W2052319364 date "2010-01-01" @default.
• W2052319364 modified "2023-10-17" @default.
• W2052319364 title "A Single Nitrous Oxide (N2O) Exposure Leads to Persistent Alleviation of Neuropathic Pain in Rats" @default.
• W2052319364 cites W1548847874 @default.
• W2052319364 cites W1851460426 @default.
• W2052319364 cites W1964023104 @default.
• W2052319364 cites W1965066118 @default.
• W2052319364 cites W1965538993 @default.
• W2052319364 cites W1978286026 @default.
• W2052319364 cites W1978381097 @default.
• W2052319364 cites W1981435820 @default.
• W2052319364 cites W1984526977 @default.
• W2052319364 cites W1992799081 @default.
• W2052319364 cites W1992811250 @default.
• W2052319364 cites W1999132886 @default.
• W2052319364 cites W2005022730 @default.
• W2052319364 cites W2008039253 @default.
• W2052319364 cites W2008496364 @default.
• W2052319364 cites W2011147200 @default.
• W2052319364 cites W2014495352 @default.
• W2052319364 cites W2014702689 @default.
• W2052319364 cites W2015608561 @default.
• W2052319364 cites W2019152169 @default.
• W2052319364 cites W2019196831 @default.
• W2052319364 cites W2023075192 @default.
• W2052319364 cites W2033001509 @default.
• W2052319364 cites W2036790219 @default.
• W2052319364 cites W2038851034 @default.
• W2052319364 cites W2058020736 @default.
• W2052319364 cites W2062625412 @default.
• W2052319364 cites W2066796908 @default.
• W2052319364 cites W2067817117 @default.
• W2052319364 cites W2071935780 @default.
• W2052319364 cites W2072686777 @default.
• W2052319364 cites W2081608455 @default.
• W2052319364 cites W2083217606 @default.
• W2052319364 cites W2085912953 @default.
• W2052319364 cites W2089633836 @default.
• W2052319364 cites W2093625464 @default.
• W2052319364 cites W2093833286 @default.
• W2052319364 cites W2113408846 @default.
• W2052319364 cites W2118233081 @default.
• W2052319364 cites W2122328323 @default.
• W2052319364 cites W2122778405 @default.
• W2052319364 cites W2124131808 @default.
• W2052319364 cites W2126575561 @default.
• W2052319364 cites W2133316133 @default.
• W2052319364 cites W2138499507 @default.
• W2052319364 cites W2138676765 @default.
• W2052319364 cites W2145977703 @default.
• W2052319364 cites W2156027902 @default.
• W2052319364 cites W2159804446 @default.
• W2052319364 cites W2165542532 @default.
• W2052319364 cites W2167613032 @default.
• W2052319364 cites W2170019750 @default.
• W2052319364 cites W2309422288 @default.
• W2052319364 cites W4233822115 @default.
• W2052319364 doi "https://doi.org/10.1016/j.jpain.2009.05.003" @default.
• W2052319364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19783223" @default.
• W2052319364 hasPublicationYear "2010" @default.
• W2052319364 type Work @default.
• W2052319364 sameAs 2052319364 @default.
• W2052319364 citedByCount "31" @default.
• W2052319364 countsByYear W20523193642012 @default.
• W2052319364 countsByYear W20523193642013 @default.
• W2052319364 countsByYear W20523193642015 @default.
• W2052319364 countsByYear W20523193642016 @default.
• W2052319364 countsByYear W20523193642021 @default.
• W2052319364 countsByYear W20523193642022 @default.
• W2052319364 crossrefType "journal-article" @default.
• W2052319364 hasAuthorship W2052319364A5010468125 @default.
• W2052319364 hasAuthorship W2052319364A5013988554 @default.
• W2052319364 hasAuthorship W2052319364A5030865521 @default.
• W2052319364 hasAuthorship W2052319364A5073839685 @default.
• W2052319364 hasAuthorship W2052319364A5090149661 @default.
• W2052319364 hasConcept C126322002 @default.
• W2052319364 hasConcept C15490471 @default.
• W2052319364 hasConcept C170493617 @default.
• W2052319364 hasConcept C2777107010 @default.
• W2052319364 hasConcept C2777573673 @default.
• W2052319364 hasConcept C2777883359 @default.
• W2052319364 hasConcept C2777972943 @default.
• W2052319364 hasConcept C2779245659 @default.
• W2052319364 hasConcept C2780820201 @default.
• W2052319364 hasConcept C2781063702 @default.
• W2052319364 hasConcept C3673659 @default.
• W2052319364 hasConcept C42219234 @default.
• W2052319364 hasConcept C71924100 @default.
• W2052319364 hasConcept C98274493 @default.
• W2052319364 hasConceptScore W2052319364C126322002 @default.
• W2052319364 hasConceptScore W2052319364C15490471 @default.

• next