FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052321896> ?p ?o ?g. }

• W2052321896 endingPage "2954" @default.
• W2052321896 startingPage "2950" @default.
• W2052321896 abstract "The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protein-tyrosine kinase. We used yeast two-hybrid screening to identify an adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT)-2 as a new partner that interacted with the cytoplasmic domain of ALK. Immunoprecipitation assay revealed that SNT-1 and SNT-2 interacted with NPM-ALK and kinase-negative NPM-ALK mutant. Y156, Y567 and a 19-amino-acid sequence (aa 631–649) of NPM-ALK were essential for this interaction. The interaction through Y156 and Y567 was dependent on phosphorylation of these tyrosines, whereas the interaction through the 19-amino-acid sequence was independent of phosphorylation. NPM-ALK mutant protein mutated at these three binding sites showed significantly reduced transforming activity. This transformation-defective NPM-ALK mutant still interacted with signal transducing proteins such as phospholipase C-gamma and phosphatidylinositol 3-kinase, which were previously reported to be relevant to NPM-ALK-dependent tumorigenesis. These observations indicate that the three SNT-binding sites of NPM-ALK are important for its transforming activity. This raises a possibility that SNT family proteins play significant roles in cellular transformation triggered by NPM-ALK, which though remains to be verified." @default.
• W2052321896 created "2016-06-24" @default.
• W2052321896 creator A5024088812 @default.
• W2052321896 creator A5024136589 @default.
• W2052321896 creator A5047100205 @default.
• W2052321896 creator A5091527014 @default.
• W2052321896 date "2006-11-06" @default.
• W2052321896 modified "2023-10-17" @default.
• W2052321896 title "Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation" @default.
• W2052321896 cites W1531048613 @default.
• W2052321896 cites W1969889989 @default.
• W2052321896 cites W1971587010 @default.
• W2052321896 cites W2008779407 @default.
• W2052321896 cites W2026002143 @default.
• W2052321896 cites W2033073864 @default.
• W2052321896 cites W2034860483 @default.
• W2052321896 cites W2038586807 @default.
• W2052321896 cites W2042386826 @default.
• W2052321896 cites W2100281377 @default.
• W2052321896 cites W2111888638 @default.
• W2052321896 cites W2124478432 @default.
• W2052321896 cites W2128153005 @default.
• W2052321896 cites W2158579806 @default.
• W2052321896 cites W2162082382 @default.
• W2052321896 cites W2164354034 @default.
• W2052321896 cites W2165080661 @default.
• W2052321896 cites W2261317284 @default.
• W2052321896 cites W2315338108 @default.
• W2052321896 doi "https://doi.org/10.1038/sj.onc.1210095" @default.
• W2052321896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17086210" @default.
• W2052321896 hasPublicationYear "2006" @default.
• W2052321896 type Work @default.
• W2052321896 sameAs 2052321896 @default.
• W2052321896 citedByCount "20" @default.
• W2052321896 countsByYear W20523218962012 @default.
• W2052321896 countsByYear W20523218962013 @default.
• W2052321896 countsByYear W20523218962015 @default.
• W2052321896 countsByYear W20523218962016 @default.
• W2052321896 countsByYear W20523218962022 @default.
• W2052321896 crossrefType "journal-article" @default.
• W2052321896 hasAuthorship W2052321896A5024088812 @default.
• W2052321896 hasAuthorship W2052321896A5024136589 @default.
• W2052321896 hasAuthorship W2052321896A5047100205 @default.
• W2052321896 hasAuthorship W2052321896A5091527014 @default.
• W2052321896 hasBestOaLocation W20523218961 @default.
• W2052321896 hasConcept C104317684 @default.
• W2052321896 hasConcept C117643217 @default.
• W2052321896 hasConcept C11960822 @default.
• W2052321896 hasConcept C141071460 @default.
• W2052321896 hasConcept C153911025 @default.
• W2052321896 hasConcept C183786373 @default.
• W2052321896 hasConcept C2776232967 @default.
• W2052321896 hasConcept C2778729363 @default.
• W2052321896 hasConcept C2779634585 @default.
• W2052321896 hasConcept C2908722627 @default.
• W2052321896 hasConcept C502942594 @default.
• W2052321896 hasConcept C55493867 @default.
• W2052321896 hasConcept C62478195 @default.
• W2052321896 hasConcept C71829478 @default.
• W2052321896 hasConcept C71924100 @default.
• W2052321896 hasConcept C86803240 @default.
• W2052321896 hasConcept C95444343 @default.
• W2052321896 hasConceptScore W2052321896C104317684 @default.
• W2052321896 hasConceptScore W2052321896C117643217 @default.
• W2052321896 hasConceptScore W2052321896C11960822 @default.
• W2052321896 hasConceptScore W2052321896C141071460 @default.
• W2052321896 hasConceptScore W2052321896C153911025 @default.
• W2052321896 hasConceptScore W2052321896C183786373 @default.
• W2052321896 hasConceptScore W2052321896C2776232967 @default.
• W2052321896 hasConceptScore W2052321896C2778729363 @default.
• W2052321896 hasConceptScore W2052321896C2779634585 @default.
• W2052321896 hasConceptScore W2052321896C2908722627 @default.
• W2052321896 hasConceptScore W2052321896C502942594 @default.
• W2052321896 hasConceptScore W2052321896C55493867 @default.
• W2052321896 hasConceptScore W2052321896C62478195 @default.
• W2052321896 hasConceptScore W2052321896C71829478 @default.
• W2052321896 hasConceptScore W2052321896C71924100 @default.
• W2052321896 hasConceptScore W2052321896C86803240 @default.
• W2052321896 hasConceptScore W2052321896C95444343 @default.
• W2052321896 hasIssue "20" @default.
• W2052321896 hasLocation W20523218961 @default.
• W2052321896 hasLocation W20523218962 @default.
• W2052321896 hasOpenAccess W2052321896 @default.
• W2052321896 hasPrimaryLocation W20523218961 @default.
• W2052321896 hasRelatedWork W1278338476 @default.
• W2052321896 hasRelatedWork W1965702849 @default.
• W2052321896 hasRelatedWork W1975510716 @default.
• W2052321896 hasRelatedWork W1978760124 @default.
• W2052321896 hasRelatedWork W1986475030 @default.
• W2052321896 hasRelatedWork W1993350279 @default.
• W2052321896 hasRelatedWork W2050903170 @default.
• W2052321896 hasRelatedWork W2063385539 @default.
• W2052321896 hasRelatedWork W2127080319 @default.
• W2052321896 hasRelatedWork W2160536323 @default.
• W2052321896 hasVolume "26" @default.
• W2052321896 isParatext "false" @default.
• W2052321896 isRetracted "false" @default.
• W2052321896 magId "2052321896" @default.

• next