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- W2052332322 abstract "Our aim was to determine the efficacy and toxicity of paclitaxel in the treatment of refractory and platinum-resistant epithelial ovarian cancer.Eligibility required three prior failed chemotherapy regimens and documented platinum resistance. One hundred patients with advanced ovarian cancer received paclitaxel 135 mg/m2 over 24 hours every 21 days with optional granulocyte colony-stimulating factor support.Paclitaxel was generally well tolerated. In four patients bowel perforation or fistula developed. After three cycles 34% of patients had stable disease and 25% of patients demonstrated a response, either partial or complete. After six cycles 24% of patients continued to respond. To date, six patients have achieved a complete response.A 25% response rate in patients with refractory ovarian cancer was observed, which was durable to six cycles." @default.
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- W2052332322 date "1994-06-01" @default.
- W2052332322 modified "2023-09-25" @default.
- W2052332322 title "Paclitaxel (Taxol) treatment for refractory ovarian cancer: Phase II clinical trial" @default.
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- W2052332322 doi "https://doi.org/10.1016/s0002-9378(94)70338-8" @default.
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