FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052336470> ?p ?o ?g. }

• W2052336470 endingPage "766" @default.
• W2052336470 startingPage "759" @default.
• W2052336470 abstract "Background and aim Increased vascular resistance is a hallmark of hypertension and involves structural alterations, which may entail smooth muscle cell hypertrophy or hyperplasia, or qualitative or quantitative changes in extracellular matrix (ECM) proteins. Since the renin–angiotensin–aldosterone system modulates these changes, we investigated the effects of 8 weeks of treatment with an angiotensin-converting enzyme (ACE) inhibitor, ramipril (RAM), or a dual ACE and neutral endopeptidase (NEP) inhibitor, MDL-100240 (MDL), on mesenteric small artery structure and ECM proteins in mRen2-transgenic rats (TGRs), an animal model of hypertension with severe cardiovascular damage. Materials and methods Thirty-five 5-week-old rats were included in the study: six TGRs received RAM; five TGRs RAM + the bradykinin receptor inhibitor, icatibant; six TGRs, MDL; and five TGRs MDL + icatibant, while eight TGRs and five normotensive Sprague–Dawley controls were kept untreated. Mesenteric small arteries were dissected and mounted on a micromyograph. The media-to-lumen ratio (M/L) was then calculated. Vascular metalloproteinase (MMP) content was evaluated by zymography. Results In untreated TGRs severe hypertension was associated with inward eutrophic remodelling of small arteries. Both RAM and MDL prevented the increase in blood pressure and M/L and decreased MMPs. Icatibant blunted the effect of MDL on BP, M/L and MMPs. Conclusions Changes in collagenase activity induced by ramipril and MDL are associated with prevention of small artery structural alterations in TGRs. Furthermore, MDL-induced enhancement of bradykinin could play a role in both the prevention of vascular structural alterations and in the stimulation of MMPs." @default.
• W2052336470 created "2016-06-24" @default.
• W2052336470 creator A5007772278 @default.
• W2052336470 creator A5017208564 @default.
• W2052336470 creator A5023636054 @default.
• W2052336470 creator A5027436936 @default.
• W2052336470 creator A5032265368 @default.
• W2052336470 creator A5048182342 @default.
• W2052336470 creator A5053616719 @default.
• W2052336470 creator A5056058523 @default.
• W2052336470 creator A5068598073 @default.
• W2052336470 creator A5072973405 @default.
• W2052336470 creator A5081068826 @default.
• W2052336470 creator A5081989161 @default.
• W2052336470 date "2004-04-01" @default.
• W2052336470 modified "2023-09-26" @default.
• W2052336470 title "Bradykinin and matrix metalloproteinases are involved the structural alterations of rat small resistance arteries with inhibition of ACE and NEP" @default.
• W2052336470 cites W1765750524 @default.
• W2052336470 cites W1967932178 @default.
• W2052336470 cites W1970445852 @default.
• W2052336470 cites W1980588083 @default.
• W2052336470 cites W1984595187 @default.
• W2052336470 cites W1986157464 @default.
• W2052336470 cites W1986894335 @default.
• W2052336470 cites W2003269305 @default.
• W2052336470 cites W2005590672 @default.
• W2052336470 cites W2008024908 @default.
• W2052336470 cites W2009328409 @default.
• W2052336470 cites W2011662658 @default.
• W2052336470 cites W2015902540 @default.
• W2052336470 cites W2017023029 @default.
• W2052336470 cites W2023143614 @default.
• W2052336470 cites W2030957028 @default.
• W2052336470 cites W2031513528 @default.
• W2052336470 cites W2032107784 @default.
• W2052336470 cites W2039323073 @default.
• W2052336470 cites W2046845297 @default.
• W2052336470 cites W2064270234 @default.
• W2052336470 cites W2084317973 @default.
• W2052336470 cites W2086832765 @default.
• W2052336470 cites W2091449966 @default.
• W2052336470 cites W2095824482 @default.
• W2052336470 cites W2097792029 @default.
• W2052336470 cites W2099090914 @default.
• W2052336470 cites W2104824409 @default.
• W2052336470 cites W2105809486 @default.
• W2052336470 cites W2112043697 @default.
• W2052336470 cites W2112980028 @default.
• W2052336470 cites W2114544525 @default.
• W2052336470 cites W2115282647 @default.
• W2052336470 cites W2126813382 @default.
• W2052336470 cites W2131629913 @default.
• W2052336470 cites W2137032419 @default.
• W2052336470 cites W2147685231 @default.
• W2052336470 cites W2153981371 @default.
• W2052336470 cites W2165971798 @default.
• W2052336470 cites W2166486996 @default.
• W2052336470 cites W2171862643 @default.
• W2052336470 cites W2326536740 @default.
• W2052336470 cites W2332887484 @default.
• W2052336470 cites W4236701548 @default.
• W2052336470 cites W4253776788 @default.
• W2052336470 doi "https://doi.org/10.1097/00004872-200404000-00019" @default.
• W2052336470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15126918" @default.
• W2052336470 hasPublicationYear "2004" @default.
• W2052336470 type Work @default.
• W2052336470 sameAs 2052336470 @default.
• W2052336470 citedByCount "22" @default.
• W2052336470 countsByYear W20523364702012 @default.
• W2052336470 countsByYear W20523364702014 @default.
• W2052336470 countsByYear W20523364702015 @default.
• W2052336470 countsByYear W20523364702021 @default.
• W2052336470 crossrefType "journal-article" @default.
• W2052336470 hasAuthorship W2052336470A5007772278 @default.
• W2052336470 hasAuthorship W2052336470A5017208564 @default.
• W2052336470 hasAuthorship W2052336470A5023636054 @default.
• W2052336470 hasAuthorship W2052336470A5027436936 @default.
• W2052336470 hasAuthorship W2052336470A5032265368 @default.
• W2052336470 hasAuthorship W2052336470A5048182342 @default.
• W2052336470 hasAuthorship W2052336470A5053616719 @default.
• W2052336470 hasAuthorship W2052336470A5056058523 @default.
• W2052336470 hasAuthorship W2052336470A5068598073 @default.
• W2052336470 hasAuthorship W2052336470A5072973405 @default.
• W2052336470 hasAuthorship W2052336470A5081068826 @default.
• W2052336470 hasAuthorship W2052336470A5081989161 @default.
• W2052336470 hasConcept C126322002 @default.
• W2052336470 hasConcept C134018914 @default.
• W2052336470 hasConcept C170493617 @default.
• W2052336470 hasConcept C27016395 @default.
• W2052336470 hasConcept C2778211319 @default.
• W2052336470 hasConcept C2779591629 @default.
• W2052336470 hasConcept C2779611605 @default.
• W2052336470 hasConcept C2779888176 @default.
• W2052336470 hasConcept C71924100 @default.
• W2052336470 hasConcept C84393581 @default.
• W2052336470 hasConceptScore W2052336470C126322002 @default.
• W2052336470 hasConceptScore W2052336470C134018914 @default.
• W2052336470 hasConceptScore W2052336470C170493617 @default.

• next