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- W2052342014 abstract "The chronotropic and inotropic responses of the isolated perfused guinea-pig heart to norepinephrine and calcium were measured in preparations obtained from untreated and reserpinetreated animals. Dose-response curves were obtained in spontaneously beating as well as electrically paced perfused hearts. The dose-response curve for the chronotropic effect of both norepinephrine and calcium was shifted to the left of control in spontaneously beating preparations from animals pretreated with reserpine (0.1 mg/kg/day) for seven days. However, in these same preparations the dose-response curve for the inotropic effect of only norepinephrine was shifted to the left. This may be reflection of the enhanced sensitivity to the chronotropic action of the agonist since a changing rate is known to influence inotropic response. This conclusion is supported by the finding that, in electrically paced perfused hearts, no postjunctional supersensitivity to the inotropic effects of norepinephrine was demonstrable. Since no supersensitivity was observed to the inotropic effects of calcium, it is concuded that true postjunctional supersensitivity develops to the chronotropic but not to the inotropic effects of drugs." @default.
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- W2052342014 date "1974-11-01" @default.
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- W2052342014 title "The effect of reserpine treatment on the chronotropic and inotropic sensitivities of the perfused guinea-pig heart to norepinephrine and calcium" @default.
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- W2052342014 doi "https://doi.org/10.1016/0014-2999(74)90176-9" @default.
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