Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052343685> ?p ?o ?g. }
- W2052343685 endingPage "837" @default.
- W2052343685 startingPage "826" @default.
- W2052343685 abstract "Autophagy is responsible for the degradation of protein aggregates and damaged organelles. Several studies have reported increased autophagic activity in tubular cells after kidney injury. Here, we examine the role of tubular cell autophagy in vivo under both physiological conditions and stress using two different tubular-specific Atg5-knockout mouse models. While Atg5 deletion in distal tubule cells does not cause a significant alteration in kidney function, deleting Atg5 in both distal and proximal tubule cells results in impaired kidney function. Already under physiological conditions, Atg5-null tubule cells display a significant accumulation of p62 and oxidative stress markers. Strikingly, tubular cell Atg5-deficiency dramatically sensitizes the kidneys to ischemic injury, resulting in impaired kidney function, accumulation of damaged mitochondria as well as increased tubular cell apoptosis and proliferation, highlighting the critical role that autophagy plays in maintaining tubular cell integrity during stress conditions." @default.
- W2052343685 created "2016-06-24" @default.
- W2052343685 creator A5004613567 @default.
- W2052343685 creator A5015868168 @default.
- W2052343685 creator A5020659144 @default.
- W2052343685 creator A5038112377 @default.
- W2052343685 creator A5039063866 @default.
- W2052343685 creator A5048410197 @default.
- W2052343685 creator A5076632645 @default.
- W2052343685 creator A5085653275 @default.
- W2052343685 date "2012-05-13" @default.
- W2052343685 modified "2023-10-18" @default.
- W2052343685 title "Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury" @default.
- W2052343685 cites W1984783960 @default.
- W2052343685 cites W1991185361 @default.
- W2052343685 cites W1992659717 @default.
- W2052343685 cites W1994823455 @default.
- W2052343685 cites W1998399313 @default.
- W2052343685 cites W2000936337 @default.
- W2052343685 cites W2011250217 @default.
- W2052343685 cites W2014918593 @default.
- W2052343685 cites W2021996063 @default.
- W2052343685 cites W2022570265 @default.
- W2052343685 cites W2022812113 @default.
- W2052343685 cites W2024184215 @default.
- W2052343685 cites W2025665129 @default.
- W2052343685 cites W2026500266 @default.
- W2052343685 cites W2030287946 @default.
- W2052343685 cites W2031308048 @default.
- W2052343685 cites W2036787961 @default.
- W2052343685 cites W2036903182 @default.
- W2052343685 cites W2050475853 @default.
- W2052343685 cites W2073625832 @default.
- W2052343685 cites W2086197089 @default.
- W2052343685 cites W2087429403 @default.
- W2052343685 cites W2091250038 @default.
- W2052343685 cites W2101721772 @default.
- W2052343685 cites W2104010513 @default.
- W2052343685 cites W2115742671 @default.
- W2052343685 cites W2119399459 @default.
- W2052343685 cites W2128537698 @default.
- W2052343685 cites W2130542877 @default.
- W2052343685 cites W2136066292 @default.
- W2052343685 cites W2138561620 @default.
- W2052343685 cites W2144522321 @default.
- W2052343685 cites W2146887271 @default.
- W2052343685 cites W2166039491 @default.
- W2052343685 cites W2167987042 @default.
- W2052343685 cites W2322187697 @default.
- W2052343685 doi "https://doi.org/10.4161/auto.19419" @default.
- W2052343685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22617445" @default.
- W2052343685 hasPublicationYear "2012" @default.
- W2052343685 type Work @default.
- W2052343685 sameAs 2052343685 @default.
- W2052343685 citedByCount "215" @default.
- W2052343685 countsByYear W20523436852012 @default.
- W2052343685 countsByYear W20523436852013 @default.
- W2052343685 countsByYear W20523436852014 @default.
- W2052343685 countsByYear W20523436852015 @default.
- W2052343685 countsByYear W20523436852016 @default.
- W2052343685 countsByYear W20523436852017 @default.
- W2052343685 countsByYear W20523436852018 @default.
- W2052343685 countsByYear W20523436852019 @default.
- W2052343685 countsByYear W20523436852020 @default.
- W2052343685 countsByYear W20523436852021 @default.
- W2052343685 countsByYear W20523436852022 @default.
- W2052343685 countsByYear W20523436852023 @default.
- W2052343685 crossrefType "journal-article" @default.
- W2052343685 hasAuthorship W2052343685A5004613567 @default.
- W2052343685 hasAuthorship W2052343685A5015868168 @default.
- W2052343685 hasAuthorship W2052343685A5020659144 @default.
- W2052343685 hasAuthorship W2052343685A5038112377 @default.
- W2052343685 hasAuthorship W2052343685A5039063866 @default.
- W2052343685 hasAuthorship W2052343685A5048410197 @default.
- W2052343685 hasAuthorship W2052343685A5076632645 @default.
- W2052343685 hasAuthorship W2052343685A5085653275 @default.
- W2052343685 hasBestOaLocation W20523436851 @default.
- W2052343685 hasConcept C134018914 @default.
- W2052343685 hasConcept C190283241 @default.
- W2052343685 hasConcept C203522944 @default.
- W2052343685 hasConcept C2776151105 @default.
- W2052343685 hasConcept C2780091579 @default.
- W2052343685 hasConcept C2780498532 @default.
- W2052343685 hasConcept C2781000418 @default.
- W2052343685 hasConcept C28859421 @default.
- W2052343685 hasConcept C31573885 @default.
- W2052343685 hasConcept C55493867 @default.
- W2052343685 hasConcept C86803240 @default.
- W2052343685 hasConcept C95444343 @default.
- W2052343685 hasConceptScore W2052343685C134018914 @default.
- W2052343685 hasConceptScore W2052343685C190283241 @default.
- W2052343685 hasConceptScore W2052343685C203522944 @default.
- W2052343685 hasConceptScore W2052343685C2776151105 @default.
- W2052343685 hasConceptScore W2052343685C2780091579 @default.
- W2052343685 hasConceptScore W2052343685C2780498532 @default.
- W2052343685 hasConceptScore W2052343685C2781000418 @default.
- W2052343685 hasConceptScore W2052343685C28859421 @default.
- W2052343685 hasConceptScore W2052343685C31573885 @default.