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- W2052350905 abstract "THE existence of a relationship between the adrenal cortex and the hypertensive state has long been conjectured (Grollman, 1936; Grollman, Harrison and Williams, 1940; Perera, 1950). Despite the many observations suggestive of the existence of such a relationship, the available data fail to support such a view. The recent interest in cortisone and the adrenocorticotrophic hormone of the pituitary (ACTH) has again aroused interest in this problem and led to the trial of these drugs in clinical hypertension. Because of the difficulties and uncertainties involved in evaluating changes observed in the blood pressure of the human subject, the effects of the above-mentioned drugs on the blood pressure in experimental renal hypertension was determined. Rats and dogs rendered hypertensive by application of a figure-of-eight ligature to one kidney and removal of the contralateral one (Grollman, 1944) were injected intramuscularly with cortisone and ACTH." @default.
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- W2052350905 date "1951-02-01" @default.
- W2052350905 modified "2023-09-27" @default.
- W2052350905 title "THE EFFECT OF CORTISONE AND THE ADRENOCORTICOTROPHIC HORMONE OF THE PITUITARY ON THE BLOOD PRESSURE IN EXPERIMENTAL RENAL HYPERTENSION1" @default.
- W2052350905 doi "https://doi.org/10.1210/endo-48-2-213" @default.
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