FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052354269> ?p ?o ?g. }

• W2052354269 endingPage "611" @default.
• W2052354269 startingPage "597" @default.
• W2052354269 abstract "Long-term consumption of high-fat diets negatively interferes with metabolic status and promotes endothelial dysfunction and inflammation. In the cavernous tissue, these outcomes become conspicuous in the elderly and strongly affect penile erection, a vascular process highly dependent on local nitric oxide bioavailability. Although epidemiological data links erectile dysfunction to nutritional patterns, the underlying molecular mechanisms remain unclear. Therefore, we investigated the effects of long-term high-fat diet on endothelial nitric oxide synthase (eNOS)–Sirtuin-1 axis and Akt/eNOS phosphorylation in the cavernous tissue of Sprague–Dawley rats, and compared with energy-restricted animals. We demonstrated that high-fat diet intake led to a noteworthy decrease in eNOS phosphorylation at Ser1177 residue through the Akt pathway, which seems to be compensated by upregulation of phosphorylation at Ser615, but without an increment in nitric oxide production. These results are accompanied by an increase of systemic inflammatory markers and upregulation of the inducible NOS and of the deacetylase Sirtuin-1 in the cavernous tissue to levels apparently detrimental to cells and to metabolic homeostasis. Conversely, in long-term energy-restricted animals, the rate of phosphorylation of eNOS at Ser1177 diminished, but the activation of the enzyme increased through phosphorylation of eNOS at Ser615, resulting in an enhancement in nitric oxide bioavailability. Taken together, our results demonstrate that long-term nutritional conditions override the influence of age on the eNOS expression and activation in rat cavernous tissue." @default.
• W2052354269 created "2016-06-24" @default.
• W2052354269 creator A5008401828 @default.
• W2052354269 creator A5015251438 @default.
• W2052354269 creator A5034048039 @default.
• W2052354269 creator A5055236064 @default.
• W2052354269 date "2013-10-09" @default.
• W2052354269 modified "2023-09-26" @default.
• W2052354269 title "Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue" @default.
• W2052354269 cites W1523896164 @default.
• W2052354269 cites W1580980304 @default.
• W2052354269 cites W1607892649 @default.
• W2052354269 cites W1769035943 @default.
• W2052354269 cites W1928263104 @default.
• W2052354269 cites W1965169520 @default.
• W2052354269 cites W1971448178 @default.
• W2052354269 cites W1973509930 @default.
• W2052354269 cites W1983986440 @default.
• W2052354269 cites W1985314891 @default.
• W2052354269 cites W1987254109 @default.
• W2052354269 cites W1988236300 @default.
• W2052354269 cites W1993719949 @default.
• W2052354269 cites W1994768696 @default.
• W2052354269 cites W1995188356 @default.
• W2052354269 cites W1995646723 @default.
• W2052354269 cites W2008697716 @default.
• W2052354269 cites W2009051902 @default.
• W2052354269 cites W2009590767 @default.
• W2052354269 cites W2016892122 @default.
• W2052354269 cites W2018444934 @default.
• W2052354269 cites W2022068135 @default.
• W2052354269 cites W2022209234 @default.
• W2052354269 cites W2022293772 @default.
• W2052354269 cites W2025674512 @default.
• W2052354269 cites W2044183408 @default.
• W2052354269 cites W2050679843 @default.
• W2052354269 cites W2052749010 @default.
• W2052354269 cites W2057210592 @default.
• W2052354269 cites W2059694609 @default.
• W2052354269 cites W2060449981 @default.
• W2052354269 cites W2064044812 @default.
• W2052354269 cites W2065335664 @default.
• W2052354269 cites W2069049877 @default.
• W2052354269 cites W2072661983 @default.
• W2052354269 cites W2074518462 @default.
• W2052354269 cites W2080192652 @default.
• W2052354269 cites W2080740489 @default.
• W2052354269 cites W2085992983 @default.
• W2052354269 cites W2092145002 @default.
• W2052354269 cites W2096285002 @default.
• W2052354269 cites W2097750015 @default.
• W2052354269 cites W2098617526 @default.
• W2052354269 cites W2100837269 @default.
• W2052354269 cites W2105169259 @default.
• W2052354269 cites W2106490387 @default.
• W2052354269 cites W2110271190 @default.
• W2052354269 cites W2118204731 @default.
• W2052354269 cites W2118569957 @default.
• W2052354269 cites W2120977310 @default.
• W2052354269 cites W2121141378 @default.
• W2052354269 cites W2126412451 @default.
• W2052354269 cites W2129448542 @default.
• W2052354269 cites W2130306317 @default.
• W2052354269 cites W2131399515 @default.
• W2052354269 cites W2132419880 @default.
• W2052354269 cites W2132693703 @default.
• W2052354269 cites W2133617398 @default.
• W2052354269 cites W2134775482 @default.
• W2052354269 cites W2138252241 @default.
• W2052354269 cites W2139500689 @default.
• W2052354269 cites W2143104968 @default.
• W2052354269 cites W2146266563 @default.
• W2052354269 cites W2158895600 @default.
• W2052354269 cites W2162306102 @default.
• W2052354269 cites W2165201727 @default.
• W2052354269 cites W2166665077 @default.
• W2052354269 cites W2169157825 @default.
• W2052354269 cites W2169695019 @default.
• W2052354269 cites W4230252272 @default.
• W2052354269 cites W4243770305 @default.
• W2052354269 doi "https://doi.org/10.1007/s11357-013-9591-2" @default.
• W2052354269 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4039277" @default.
• W2052354269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24105250" @default.
• W2052354269 hasPublicationYear "2013" @default.
• W2052354269 type Work @default.
• W2052354269 sameAs 2052354269 @default.
• W2052354269 citedByCount "12" @default.
• W2052354269 countsByYear W20523542692014 @default.
• W2052354269 countsByYear W20523542692015 @default.
• W2052354269 countsByYear W20523542692016 @default.
• W2052354269 countsByYear W20523542692017 @default.
• W2052354269 countsByYear W20523542692018 @default.
• W2052354269 countsByYear W20523542692020 @default.
• W2052354269 crossrefType "journal-article" @default.
• W2052354269 hasAuthorship W2052354269A5008401828 @default.
• W2052354269 hasAuthorship W2052354269A5015251438 @default.
• W2052354269 hasAuthorship W2052354269A5034048039 @default.
• W2052354269 hasAuthorship W2052354269A5055236064 @default.

• next