Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052362708> ?p ?o ?g. }
- W2052362708 endingPage "615" @default.
- W2052362708 startingPage "605" @default.
- W2052362708 abstract "Summary A lzheimer's disease ( AD ) is the most common form of dementia and displays the characteristics of chronic neurodegenerative disorders; amyloid plaques ( AP ) that contain amyloid β‐protein (Aβ) accumulate in AD , which is also characterized by tau phosphorylation. Epidemiological evidence has demonstrated that long‐term treatment with nonsteroidal anti‐inflammatory drugs ( NSAID s) markedly reduces the risk of AD by inhibiting the expression of cyclooxygenase 2 ( COX ‐2). Although the levels of COX ‐2 and its metabolic product prostaglandin ( PG ) E 2 are elevated in the brain of AD patients, the mechanisms for the development of AD remain unknown. Using human‐ or mouse‐derived glioblastoma and neuroblastoma cell lines as model systems, we delineated the signaling pathways by which COX ‐2 mediates the reciprocal regulation of interleukin‐1β ( IL ‐1β) and Aβ between glial and neuron cells. In glioblastoma cells, COX ‐2 regulates the synthesis of IL ‐1β in a PGE 2 ‐dependent manner. Moreover, COX ‐2‐derived PGE 2 signals the activation of the PI 3‐ K / AKT and PKA / CREB pathways via cyclic AMP ; these pathways transactivate the NF ‐κB p65 subunit via phosphorylation at S er 536 and S er 276, leading to IL ‐1β synthesis. The secretion of IL ‐1β from glioblastoma cells in turn stimulates the expression of COX ‐2 in human or mouse neuroblastoma cells. Similar regulatory mechanisms were found for the COX ‐2 regulation of BACE ‐1 expression in neuroblastoma cells. More importantly, Aβ deposition mediated the inflammatory response of glial cells via inducing the expression of COX ‐2 in glioblastoma cells. These findings not only provide new insights into the mechanisms of COX ‐2‐induced AD but also initially define the therapeutic targets of AD ." @default.
- W2052362708 created "2016-06-24" @default.
- W2052362708 creator A5040899817 @default.
- W2052362708 creator A5061069488 @default.
- W2052362708 creator A5063192101 @default.
- W2052362708 creator A5075715258 @default.
- W2052362708 creator A5081529796 @default.
- W2052362708 creator A5085142676 @default.
- W2052362708 date "2014-03-13" @default.
- W2052362708 modified "2023-10-17" @default.
- W2052362708 title "Aggravation of <scp>A</scp> lzheimer's disease due to the <scp>COX</scp> ‐2‐mediated reciprocal regulation of <scp>IL</scp> ‐1β and <scp>A</scp> β between glial and neuron cells" @default.
- W2052362708 cites W1965417918 @default.
- W2052362708 cites W1965627667 @default.
- W2052362708 cites W1969302633 @default.
- W2052362708 cites W1972976060 @default.
- W2052362708 cites W1974194572 @default.
- W2052362708 cites W1979564777 @default.
- W2052362708 cites W1979783069 @default.
- W2052362708 cites W1985385208 @default.
- W2052362708 cites W1989469359 @default.
- W2052362708 cites W1994467653 @default.
- W2052362708 cites W1995376418 @default.
- W2052362708 cites W2003283600 @default.
- W2052362708 cites W2005777709 @default.
- W2052362708 cites W2007158999 @default.
- W2052362708 cites W2015163544 @default.
- W2052362708 cites W2023187813 @default.
- W2052362708 cites W2037174379 @default.
- W2052362708 cites W2039453997 @default.
- W2052362708 cites W2039639602 @default.
- W2052362708 cites W2045764828 @default.
- W2052362708 cites W2055092854 @default.
- W2052362708 cites W2057270928 @default.
- W2052362708 cites W2069293496 @default.
- W2052362708 cites W2071070914 @default.
- W2052362708 cites W2071695496 @default.
- W2052362708 cites W2076233136 @default.
- W2052362708 cites W2082452384 @default.
- W2052362708 cites W2090464516 @default.
- W2052362708 cites W2101292939 @default.
- W2052362708 cites W2116784956 @default.
- W2052362708 cites W2129111164 @default.
- W2052362708 cites W2140131793 @default.
- W2052362708 cites W2146957909 @default.
- W2052362708 cites W2150356698 @default.
- W2052362708 cites W2151749372 @default.
- W2052362708 cites W2161926550 @default.
- W2052362708 cites W2167461417 @default.
- W2052362708 cites W2170722828 @default.
- W2052362708 cites W2171469414 @default.
- W2052362708 cites W2292619439 @default.
- W2052362708 cites W31545652 @default.
- W2052362708 cites W4247904703 @default.
- W2052362708 doi "https://doi.org/10.1111/acel.12209" @default.
- W2052362708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4326948" @default.
- W2052362708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24621265" @default.
- W2052362708 hasPublicationYear "2014" @default.
- W2052362708 type Work @default.
- W2052362708 sameAs 2052362708 @default.
- W2052362708 citedByCount "74" @default.
- W2052362708 countsByYear W20523627082015 @default.
- W2052362708 countsByYear W20523627082016 @default.
- W2052362708 countsByYear W20523627082017 @default.
- W2052362708 countsByYear W20523627082018 @default.
- W2052362708 countsByYear W20523627082019 @default.
- W2052362708 countsByYear W20523627082020 @default.
- W2052362708 countsByYear W20523627082021 @default.
- W2052362708 countsByYear W20523627082022 @default.
- W2052362708 countsByYear W20523627082023 @default.
- W2052362708 crossrefType "journal-article" @default.
- W2052362708 hasAuthorship W2052362708A5040899817 @default.
- W2052362708 hasAuthorship W2052362708A5061069488 @default.
- W2052362708 hasAuthorship W2052362708A5063192101 @default.
- W2052362708 hasAuthorship W2052362708A5075715258 @default.
- W2052362708 hasAuthorship W2052362708A5081529796 @default.
- W2052362708 hasAuthorship W2052362708A5085142676 @default.
- W2052362708 hasBestOaLocation W20523627082 @default.
- W2052362708 hasConcept C104317684 @default.
- W2052362708 hasConcept C11960822 @default.
- W2052362708 hasConcept C134018914 @default.
- W2052362708 hasConcept C1629964 @default.
- W2052362708 hasConcept C203014093 @default.
- W2052362708 hasConcept C2776715637 @default.
- W2052362708 hasConcept C2777956040 @default.
- W2052362708 hasConcept C502942594 @default.
- W2052362708 hasConcept C54355233 @default.
- W2052362708 hasConcept C55493867 @default.
- W2052362708 hasConcept C62478195 @default.
- W2052362708 hasConcept C75217442 @default.
- W2052362708 hasConcept C81885089 @default.
- W2052362708 hasConcept C86339819 @default.
- W2052362708 hasConcept C86803240 @default.
- W2052362708 hasConcept C95444343 @default.
- W2052362708 hasConceptScore W2052362708C104317684 @default.
- W2052362708 hasConceptScore W2052362708C11960822 @default.
- W2052362708 hasConceptScore W2052362708C134018914 @default.
- W2052362708 hasConceptScore W2052362708C1629964 @default.
- W2052362708 hasConceptScore W2052362708C203014093 @default.