FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052364512> ?p ?o ?g. }

• W2052364512 endingPage "10422" @default.
• W2052364512 startingPage "10417" @default.
• W2052364512 abstract "Early atherosclerotic lesions develop in a topographical pattern that strongly suggests involvement of hemodynamic forces in their pathogenesis. We hypothesized that certain endothelial genes, which exhibit differential responsiveness to distinct fluid mechanical stimuli, may participate in the atherogenic process by modulating, on a local level within the arterial wall, the effects of systemic risk factors. A differential display strategy using cultured human endothelial cells has identified two genes, manganese superoxide dismutase and cyclooxygenase-2, that exhibit selective and sustained up-regulation by steady laminar shear stress (LSS). Turbulent shear stress, a nonlaminar fluid mechanical stimulus, does not induce these genes. The endothelial form of nitric oxide synthase also demonstrates a similar LSS-selective pattern of induction. Thus, three genes with potential atheroprotective (antioxidant, antithrombotic, and antiadhesive) activities manifest a differential response to distinct fluid mechanical stimuli, providing a possible mechanistic link between endothelial gene expression and early events in atherogenesis. The activities of these and other LSS-responsive genes may have important implications for the pathogenesis and prevention of atherosclerosis." @default.
• W2052364512 created "2016-06-24" @default.
• W2052364512 creator A5075934069 @default.
• W2052364512 creator A5079166459 @default.
• W2052364512 creator A5084435159 @default.
• W2052364512 creator A5084684343 @default.
• W2052364512 date "1996-09-17" @default.
• W2052364512 modified "2023-10-18" @default.
• W2052364512 title "Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress." @default.
• W2052364512 cites W1536031017 @default.
• W2052364512 cites W1544157645 @default.
• W2052364512 cites W1564202134 @default.
• W2052364512 cites W1587059515 @default.
• W2052364512 cites W1590052782 @default.
• W2052364512 cites W1839057479 @default.
• W2052364512 cites W1857052429 @default.
• W2052364512 cites W1921434079 @default.
• W2052364512 cites W1936770188 @default.
• W2052364512 cites W1964814612 @default.
• W2052364512 cites W1966883946 @default.
• W2052364512 cites W1975529354 @default.
• W2052364512 cites W1978368163 @default.
• W2052364512 cites W1981175423 @default.
• W2052364512 cites W1981727007 @default.
• W2052364512 cites W1982126266 @default.
• W2052364512 cites W198417399 @default.
• W2052364512 cites W1985637499 @default.
• W2052364512 cites W2009251691 @default.
• W2052364512 cites W2019033741 @default.
• W2052364512 cites W2026075546 @default.
• W2052364512 cites W2043707891 @default.
• W2052364512 cites W2047104741 @default.
• W2052364512 cites W2051864488 @default.
• W2052364512 cites W2065591461 @default.
• W2052364512 cites W2078789063 @default.
• W2052364512 cites W2083217753 @default.
• W2052364512 cites W2083651943 @default.
• W2052364512 cites W2089923844 @default.
• W2052364512 cites W2094258013 @default.
• W2052364512 cites W2099992849 @default.
• W2052364512 cites W2100124039 @default.
• W2052364512 cites W2100994529 @default.
• W2052364512 cites W2111076607 @default.
• W2052364512 cites W2120871101 @default.
• W2052364512 cites W2125764762 @default.
• W2052364512 cites W2126524259 @default.
• W2052364512 cites W2128539657 @default.
• W2052364512 cites W2131868847 @default.
• W2052364512 cites W2134785329 @default.
• W2052364512 cites W2135038548 @default.
• W2052364512 cites W2137570167 @default.
• W2052364512 cites W2158686638 @default.
• W2052364512 cites W2160301642 @default.
• W2052364512 cites W2162010936 @default.
• W2052364512 cites W2327085010 @default.
• W2052364512 cites W2418479876 @default.
• W2052364512 cites W2419512130 @default.
• W2052364512 cites W2431238225 @default.
• W2052364512 doi "https://doi.org/10.1073/pnas.93.19.10417" @default.
• W2052364512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38399" @default.
• W2052364512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8816815" @default.
• W2052364512 hasPublicationYear "1996" @default.
• W2052364512 type Work @default.
• W2052364512 sameAs 2052364512 @default.
• W2052364512 citedByCount "802" @default.
• W2052364512 countsByYear W20523645122012 @default.
• W2052364512 countsByYear W20523645122013 @default.
• W2052364512 countsByYear W20523645122014 @default.
• W2052364512 countsByYear W20523645122015 @default.
• W2052364512 countsByYear W20523645122016 @default.
• W2052364512 countsByYear W20523645122017 @default.
• W2052364512 countsByYear W20523645122018 @default.
• W2052364512 countsByYear W20523645122019 @default.
• W2052364512 countsByYear W20523645122020 @default.
• W2052364512 countsByYear W20523645122021 @default.
• W2052364512 countsByYear W20523645122022 @default.
• W2052364512 countsByYear W20523645122023 @default.
• W2052364512 crossrefType "journal-article" @default.
• W2052364512 hasAuthorship W2052364512A5075934069 @default.
• W2052364512 hasAuthorship W2052364512A5079166459 @default.
• W2052364512 hasAuthorship W2052364512A5084435159 @default.
• W2052364512 hasAuthorship W2052364512A5084684343 @default.
• W2052364512 hasBestOaLocation W20523645121 @default.
• W2052364512 hasConcept C123012128 @default.
• W2052364512 hasConcept C134018914 @default.
• W2052364512 hasConcept C181199279 @default.
• W2052364512 hasConcept C185592680 @default.
• W2052364512 hasConcept C202751555 @default.
• W2052364512 hasConcept C2775838275 @default.
• W2052364512 hasConcept C2776151105 @default.
• W2052364512 hasConcept C2776992346 @default.
• W2052364512 hasConcept C2777622882 @default.
• W2052364512 hasConcept C2779689624 @default.
• W2052364512 hasConcept C2780972559 @default.
• W2052364512 hasConcept C519581460 @default.
• W2052364512 hasConcept C55493867 @default.
• W2052364512 hasConcept C86803240 @default.
• W2052364512 hasConcept C95444343 @default.

• next