FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2052364673> ?p ?o ?g. }

• W2052364673 endingPage "398" @default.
• W2052364673 startingPage "398" @default.
• W2052364673 abstract "The pathogenesis of psoriasis may involve the interleukin (IL)-23 and Th17-mediated immune responses. Th17 cells secret IL-17 and IL-22, which mediates dermal inflammation and acanthosis.As inhibitor of nuclear factor κB kinase-α (IKKα) has been previously identified as a primary regulator of keratinocyte differentiation and proliferation, we proposed that IL-17 and IL-22 might affect keratinocyte differentiation by changing the expression of IKKα.We employed HaCaT cells maintained culture medium at a low calcium concentration (0.06 mM) and induced differentiation by switching to the high concentration (2.8 mM) media with IL-17 or IL-22, then compared the IKKα expression and the cell cycle. We employed reconstituted human epidermal skin (Neoderm) and mice ears for the in vivo studies.Elevated calcium concentration induced IKKα expression and terminal differentiation with cell cycle arrest in HaCaT cell cultures. Moreover, IL-17 and IL-22 treatment also induced IKKα in HaCaT cells and reconstituted human epidermis. IKKα induction was also noted, following the injection of IL-17 and IL-22 into mice ears.Although the induction of IKKα was accompanied by keratinocyte differentiation, IL-17 and IL-22 did not affect calcium-mediated differentiation or the cell cycle. Rather, IL-17 and IL-22 appear to contribute to the inflammation occurring via the induction of IKKα from keratinocytes or skin layers." @default.
• W2052364673 created "2016-06-24" @default.
• W2052364673 creator A5008157839 @default.
• W2052364673 creator A5011346484 @default.
• W2052364673 creator A5019619340 @default.
• W2052364673 creator A5041007677 @default.
• W2052364673 creator A5062071958 @default.
• W2052364673 creator A5076182776 @default.
• W2052364673 date "2012-01-01" @default.
• W2052364673 modified "2023-09-26" @default.
• W2052364673 title "Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear Factor κB Kinase-α Expression" @default.
• W2052364673 cites W1522354953 @default.
• W2052364673 cites W1568067102 @default.
• W2052364673 cites W1576903429 @default.
• W2052364673 cites W1759028523 @default.
• W2052364673 cites W1931885032 @default.
• W2052364673 cites W2007121925 @default.
• W2052364673 cites W2012077729 @default.
• W2052364673 cites W2022205989 @default.
• W2052364673 cites W2039303828 @default.
• W2052364673 cites W2042431428 @default.
• W2052364673 cites W2045182840 @default.
• W2052364673 cites W2064296356 @default.
• W2052364673 cites W2082289095 @default.
• W2052364673 cites W2145881729 @default.
• W2052364673 doi "https://doi.org/10.5021/ad.2012.24.4.398" @default.
• W2052364673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3505769" @default.
• W2052364673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23197904" @default.
• W2052364673 hasPublicationYear "2012" @default.
• W2052364673 type Work @default.
• W2052364673 sameAs 2052364673 @default.
• W2052364673 citedByCount "22" @default.
• W2052364673 countsByYear W20523646732013 @default.
• W2052364673 countsByYear W20523646732014 @default.
• W2052364673 countsByYear W20523646732015 @default.
• W2052364673 countsByYear W20523646732016 @default.
• W2052364673 countsByYear W20523646732017 @default.
• W2052364673 countsByYear W20523646732019 @default.
• W2052364673 countsByYear W20523646732020 @default.
• W2052364673 countsByYear W20523646732021 @default.
• W2052364673 countsByYear W20523646732022 @default.
• W2052364673 countsByYear W20523646732023 @default.
• W2052364673 crossrefType "journal-article" @default.
• W2052364673 hasAuthorship W2052364673A5008157839 @default.
• W2052364673 hasAuthorship W2052364673A5011346484 @default.
• W2052364673 hasAuthorship W2052364673A5019619340 @default.
• W2052364673 hasAuthorship W2052364673A5041007677 @default.
• W2052364673 hasAuthorship W2052364673A5062071958 @default.
• W2052364673 hasAuthorship W2052364673A5076182776 @default.
• W2052364673 hasBestOaLocation W20523646732 @default.
• W2052364673 hasConcept C100175707 @default.
• W2052364673 hasConcept C105702510 @default.
• W2052364673 hasConcept C116024289 @default.
• W2052364673 hasConcept C118995209 @default.
• W2052364673 hasConcept C153911025 @default.
• W2052364673 hasConcept C164027704 @default.
• W2052364673 hasConcept C181901479 @default.
• W2052364673 hasConcept C203014093 @default.
• W2052364673 hasConcept C2776458125 @default.
• W2052364673 hasConcept C2776914184 @default.
• W2052364673 hasConcept C2777074287 @default.
• W2052364673 hasConcept C2777730290 @default.
• W2052364673 hasConcept C2778690821 @default.
• W2052364673 hasConcept C502942594 @default.
• W2052364673 hasConcept C54355233 @default.
• W2052364673 hasConcept C62478195 @default.
• W2052364673 hasConcept C71924100 @default.
• W2052364673 hasConcept C74172505 @default.
• W2052364673 hasConcept C81885089 @default.
• W2052364673 hasConcept C86803240 @default.
• W2052364673 hasConcept C95444343 @default.
• W2052364673 hasConceptScore W2052364673C100175707 @default.
• W2052364673 hasConceptScore W2052364673C105702510 @default.
• W2052364673 hasConceptScore W2052364673C116024289 @default.
• W2052364673 hasConceptScore W2052364673C118995209 @default.
• W2052364673 hasConceptScore W2052364673C153911025 @default.
• W2052364673 hasConceptScore W2052364673C164027704 @default.
• W2052364673 hasConceptScore W2052364673C181901479 @default.
• W2052364673 hasConceptScore W2052364673C203014093 @default.
• W2052364673 hasConceptScore W2052364673C2776458125 @default.
• W2052364673 hasConceptScore W2052364673C2776914184 @default.
• W2052364673 hasConceptScore W2052364673C2777074287 @default.
• W2052364673 hasConceptScore W2052364673C2777730290 @default.
• W2052364673 hasConceptScore W2052364673C2778690821 @default.
• W2052364673 hasConceptScore W2052364673C502942594 @default.
• W2052364673 hasConceptScore W2052364673C54355233 @default.
• W2052364673 hasConceptScore W2052364673C62478195 @default.
• W2052364673 hasConceptScore W2052364673C71924100 @default.
• W2052364673 hasConceptScore W2052364673C74172505 @default.
• W2052364673 hasConceptScore W2052364673C81885089 @default.
• W2052364673 hasConceptScore W2052364673C86803240 @default.
• W2052364673 hasConceptScore W2052364673C95444343 @default.
• W2052364673 hasIssue "4" @default.
• W2052364673 hasLocation W20523646731 @default.
• W2052364673 hasLocation W20523646732 @default.
• W2052364673 hasLocation W20523646733 @default.
• W2052364673 hasLocation W20523646734 @default.
• W2052364673 hasOpenAccess W2052364673 @default.

• next