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- W2052373923 abstract "Antistreptococcal prophylaxis was discontinued, by double-blind techniques, in selected older adolescents, without heart disease, who had remained free of recurrent rheumatic fever for 3 to 5 years after an unequivocal episode. In 138 patient-years of observation, the group receiving oral potassium penicillin G, 200,000 units daily, developed 30 streptococcal infections (attack rate, 22%) and 1 rheumatic recurrence (attack rate, 0.7%). During 140 patient-years, the placebo group developed 30 streptococcal infections (attack rate, 21%) and 2 rheumatic recurrences (attack rate, 1.4%). None of the attack rate differences was statistically significant, and no overt new cardiac damage appeared in the three patients who developed rheumatic recurrences. Further studies would be desirable to determine the value of maintaining (or discontinuing) prophylaxis in the particular type of patient described here." @default.
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- W2052373923 date "1966-09-19" @default.
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- W2052373923 title "Discontinuation of Antistreptococcal Prophylaxis" @default.
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- W2052373923 doi "https://doi.org/10.1001/jama.1966.03110120055013" @default.
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